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Functional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI.

Faull OK, Jenkinson M, Clare S, Pattinson KT - Neuroimage (2015)

Bottom Line: Animal models have also demonstrated a columnar structure that subdivides the PAG into four columns on each side, and these subdivisions have different functions with regard to respiration.Our results showed deactivation in the lateral and dorsomedial columns of the PAG corresponding with short (~10s) breath holds, along with cortical activations consistent with previous respiratory imaging studies.These results demonstrate the involvement of the lateral and dorsomedial PAG in the network of conscious respiratory control for the first time in humans.

View Article: PubMed Central - PubMed

Affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: olivia.faull@ndcn.ox.ac.uk.

No MeSH data available.


Demonstration of the use of finger opposition as a functional localiser in brainstem fMRI at 3 T and at 7 T, by imaging activation in the ipsilateral cuneate nucleus of the medulla (z -54). The 3 T data is derived from previously-published results (Pattinson et al., 2009a). This technique provides confidence in the analysis model and registration accuracy of the current 7 T study. The images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Significant regions are displayed with a threshold Z > 2.3, with a cluster probability threshold of p < 0.05 (corrected for multiple comparisons). The sagittal image on the right displays the position of slices, for clarity only displayed from the 7 T acquisition. Abbreviations: R, raphe nuclei; ret, nuclei reticularis; VII, facial nucleus; Amb, nucleus ambiguous; IX, glossopharyngeal nucleus; NTS, nucleus tractus solitaries; GC, gracile (medial) and cuneate (lateral) nuclei (in blue). R (right) and L (left) indicate image orientation. Original line drawings adapted from Duvernoy (1995).
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f0025: Demonstration of the use of finger opposition as a functional localiser in brainstem fMRI at 3 T and at 7 T, by imaging activation in the ipsilateral cuneate nucleus of the medulla (z -54). The 3 T data is derived from previously-published results (Pattinson et al., 2009a). This technique provides confidence in the analysis model and registration accuracy of the current 7 T study. The images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Significant regions are displayed with a threshold Z > 2.3, with a cluster probability threshold of p < 0.05 (corrected for multiple comparisons). The sagittal image on the right displays the position of slices, for clarity only displayed from the 7 T acquisition. Abbreviations: R, raphe nuclei; ret, nuclei reticularis; VII, facial nucleus; Amb, nucleus ambiguous; IX, glossopharyngeal nucleus; NTS, nucleus tractus solitaries; GC, gracile (medial) and cuneate (lateral) nuclei (in blue). R (right) and L (left) indicate image orientation. Original line drawings adapted from Duvernoy (1995).

Mentions: Finger opposition resulted in significant signal increases bilaterally in the motor cortex (more extensive activation in the contralateral left motor cortex), supplementary motor cortex, anterior cingulate (ACC) and paracingulate cortices, primary sensory cortex, anterior insula cortex, operculum, caudate nucleus and putamen (supplementary Fig. 1). Bilateral signal increases were seen in the thalamic VPL nuclei, as well as the left thalamic VPM nucleus. In addition, activations were observed in the left subthalamic and red nuclei, left pons, right (ipsilateral) cuneate nucleus of the medulla (Fig. 5), and bilateral cerebellum (VI and VIIIa lobules).


Functional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI.

Faull OK, Jenkinson M, Clare S, Pattinson KT - Neuroimage (2015)

Demonstration of the use of finger opposition as a functional localiser in brainstem fMRI at 3 T and at 7 T, by imaging activation in the ipsilateral cuneate nucleus of the medulla (z -54). The 3 T data is derived from previously-published results (Pattinson et al., 2009a). This technique provides confidence in the analysis model and registration accuracy of the current 7 T study. The images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Significant regions are displayed with a threshold Z > 2.3, with a cluster probability threshold of p < 0.05 (corrected for multiple comparisons). The sagittal image on the right displays the position of slices, for clarity only displayed from the 7 T acquisition. Abbreviations: R, raphe nuclei; ret, nuclei reticularis; VII, facial nucleus; Amb, nucleus ambiguous; IX, glossopharyngeal nucleus; NTS, nucleus tractus solitaries; GC, gracile (medial) and cuneate (lateral) nuclei (in blue). R (right) and L (left) indicate image orientation. Original line drawings adapted from Duvernoy (1995).
© Copyright Policy - CC BY
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4441042&req=5

f0025: Demonstration of the use of finger opposition as a functional localiser in brainstem fMRI at 3 T and at 7 T, by imaging activation in the ipsilateral cuneate nucleus of the medulla (z -54). The 3 T data is derived from previously-published results (Pattinson et al., 2009a). This technique provides confidence in the analysis model and registration accuracy of the current 7 T study. The images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Significant regions are displayed with a threshold Z > 2.3, with a cluster probability threshold of p < 0.05 (corrected for multiple comparisons). The sagittal image on the right displays the position of slices, for clarity only displayed from the 7 T acquisition. Abbreviations: R, raphe nuclei; ret, nuclei reticularis; VII, facial nucleus; Amb, nucleus ambiguous; IX, glossopharyngeal nucleus; NTS, nucleus tractus solitaries; GC, gracile (medial) and cuneate (lateral) nuclei (in blue). R (right) and L (left) indicate image orientation. Original line drawings adapted from Duvernoy (1995).
Mentions: Finger opposition resulted in significant signal increases bilaterally in the motor cortex (more extensive activation in the contralateral left motor cortex), supplementary motor cortex, anterior cingulate (ACC) and paracingulate cortices, primary sensory cortex, anterior insula cortex, operculum, caudate nucleus and putamen (supplementary Fig. 1). Bilateral signal increases were seen in the thalamic VPL nuclei, as well as the left thalamic VPM nucleus. In addition, activations were observed in the left subthalamic and red nuclei, left pons, right (ipsilateral) cuneate nucleus of the medulla (Fig. 5), and bilateral cerebellum (VI and VIIIa lobules).

Bottom Line: Animal models have also demonstrated a columnar structure that subdivides the PAG into four columns on each side, and these subdivisions have different functions with regard to respiration.Our results showed deactivation in the lateral and dorsomedial columns of the PAG corresponding with short (~10s) breath holds, along with cortical activations consistent with previous respiratory imaging studies.These results demonstrate the involvement of the lateral and dorsomedial PAG in the network of conscious respiratory control for the first time in humans.

View Article: PubMed Central - PubMed

Affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: olivia.faull@ndcn.ox.ac.uk.

No MeSH data available.