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Functional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI.

Faull OK, Jenkinson M, Clare S, Pattinson KT - Neuroimage (2015)

Bottom Line: Animal models have also demonstrated a columnar structure that subdivides the PAG into four columns on each side, and these subdivisions have different functions with regard to respiration.Our results showed deactivation in the lateral and dorsomedial columns of the PAG corresponding with short (~10s) breath holds, along with cortical activations consistent with previous respiratory imaging studies.These results demonstrate the involvement of the lateral and dorsomedial PAG in the network of conscious respiratory control for the first time in humans.

View Article: PubMed Central - PubMed

Affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: olivia.faull@ndcn.ox.ac.uk.

No MeSH data available.


Periaqueductal grey (PAG) response to breath hold. A. Representation of the location of the PAG within the brain, three sagittal slices and the current opinion of the subdivisions of the PAG. B. Localisation of the functional decreases in BOLD signal within the PAG (p < 0.05; small-volume-corrected for multiple comparisons using overlaid PAG mask), where the images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Dashed line represents Z-10 location. C. Uncorrected Z score image of PAG deactivation from whole brain analysis, prior to masking. Abbreviations: SN, substantia nigra; RN, red nucleus; SC, superior colliculus; SCP, superior cerebellar peduncle; ICN, inter-colliculi nucleus; IC, inferior colliculus; vl, ventrolateral PAG, l, lateral PAG; dl, dorsolateral PAG; dm, dorsomedial PAG.
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f0015: Periaqueductal grey (PAG) response to breath hold. A. Representation of the location of the PAG within the brain, three sagittal slices and the current opinion of the subdivisions of the PAG. B. Localisation of the functional decreases in BOLD signal within the PAG (p < 0.05; small-volume-corrected for multiple comparisons using overlaid PAG mask), where the images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Dashed line represents Z-10 location. C. Uncorrected Z score image of PAG deactivation from whole brain analysis, prior to masking. Abbreviations: SN, substantia nigra; RN, red nucleus; SC, superior colliculus; SCP, superior cerebellar peduncle; ICN, inter-colliculi nucleus; IC, inferior colliculus; vl, ventrolateral PAG, l, lateral PAG; dl, dorsolateral PAG; dm, dorsomedial PAG.

Mentions: The results from a small-volume family-wise-error corrected analysis of the PAG revealed significant (p < 0.05) deactivation in two areas correlating with the breath hold task (Fig. 3). One of these deactivation clusters followed the lateral column on the right side of the PAG (12 voxels), and the second was located in the right caudal dorsolateral PAG (8 voxels). Uncorrected z scores within the PAG are also presented in Fig. 3, demonstrating the deactivations extending to the inferior border of the PAG. Column locations were defined using tractography results from a recent diffusion tensor imaging study (Ezra et al., ISMRM abstract, 2014). No significant activations or deactivations were found in the PAG for either vocalisation or the finger opposition task.


Functional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI.

Faull OK, Jenkinson M, Clare S, Pattinson KT - Neuroimage (2015)

Periaqueductal grey (PAG) response to breath hold. A. Representation of the location of the PAG within the brain, three sagittal slices and the current opinion of the subdivisions of the PAG. B. Localisation of the functional decreases in BOLD signal within the PAG (p < 0.05; small-volume-corrected for multiple comparisons using overlaid PAG mask), where the images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Dashed line represents Z-10 location. C. Uncorrected Z score image of PAG deactivation from whole brain analysis, prior to masking. Abbreviations: SN, substantia nigra; RN, red nucleus; SC, superior colliculus; SCP, superior cerebellar peduncle; ICN, inter-colliculi nucleus; IC, inferior colliculus; vl, ventrolateral PAG, l, lateral PAG; dl, dorsolateral PAG; dm, dorsomedial PAG.
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Related In: Results  -  Collection

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f0015: Periaqueductal grey (PAG) response to breath hold. A. Representation of the location of the PAG within the brain, three sagittal slices and the current opinion of the subdivisions of the PAG. B. Localisation of the functional decreases in BOLD signal within the PAG (p < 0.05; small-volume-corrected for multiple comparisons using overlaid PAG mask), where the images consist of a colour-rendered statistical map superimposed on a standard (MNI 1 mm3) brain. Dashed line represents Z-10 location. C. Uncorrected Z score image of PAG deactivation from whole brain analysis, prior to masking. Abbreviations: SN, substantia nigra; RN, red nucleus; SC, superior colliculus; SCP, superior cerebellar peduncle; ICN, inter-colliculi nucleus; IC, inferior colliculus; vl, ventrolateral PAG, l, lateral PAG; dl, dorsolateral PAG; dm, dorsomedial PAG.
Mentions: The results from a small-volume family-wise-error corrected analysis of the PAG revealed significant (p < 0.05) deactivation in two areas correlating with the breath hold task (Fig. 3). One of these deactivation clusters followed the lateral column on the right side of the PAG (12 voxels), and the second was located in the right caudal dorsolateral PAG (8 voxels). Uncorrected z scores within the PAG are also presented in Fig. 3, demonstrating the deactivations extending to the inferior border of the PAG. Column locations were defined using tractography results from a recent diffusion tensor imaging study (Ezra et al., ISMRM abstract, 2014). No significant activations or deactivations were found in the PAG for either vocalisation or the finger opposition task.

Bottom Line: Animal models have also demonstrated a columnar structure that subdivides the PAG into four columns on each side, and these subdivisions have different functions with regard to respiration.Our results showed deactivation in the lateral and dorsomedial columns of the PAG corresponding with short (~10s) breath holds, along with cortical activations consistent with previous respiratory imaging studies.These results demonstrate the involvement of the lateral and dorsomedial PAG in the network of conscious respiratory control for the first time in humans.

View Article: PubMed Central - PubMed

Affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: olivia.faull@ndcn.ox.ac.uk.

No MeSH data available.