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Methods and challenges in measuring the impact of national pneumococcal and rotavirus vaccine introduction on morbidity and mortality in Malawi.

Bar-Zeev N, Kapanda L, King C, Beard J, Phiri T, Mvula H, Crampin AC, Mwansambo C, Costello A, Parashar U, Tate JE, Verani JR, Whitney CG, Heyderman RS, Cunliffe NA, French N, VacSurv Consorti - Vaccine (2015)

Bottom Line: Evaluating their effectiveness is vital to ensure optimal implementation and justify sustained investment.In the context of multiple population level interventions targeting study endpoints attribution of reduced incidence to vaccine impact may be flawed.Careful evaluation of vaccine effectiveness and impact in such settings is critical to sustaining support for vaccine programmes.

View Article: PubMed Central - PubMed

Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi; Institute of Infection & Global Health, University of Liverpool, Liverpool, UK. Electronic address: Naor.Bar-Zeev@liverpool.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Structure of data flow for the Mchinji Mortality Cohort Study.
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fig0010: Structure of data flow for the Mchinji Mortality Cohort Study.

Mentions: Central Malawi: Mchinji district population was 456,516 persons in the 2008 census, with an estimated live birth rate of 57 per 1000 population [32,33]. We conducted a baseline census of Mchinji district in March 2012. Ongoing prospective surveillance of over 2000 villages in the district is conducted for births and deaths or migration of children under 5 and women of child-bearing age. Village informants report vital events monthly, supported by enumerators, supervised by monitoring and evaluation officers (Fig. 2). Live births are followed to 1 year of age or death or emigration from the district. All deaths reported by informants are verified and cause of death determined by verbal autopsy. Vaccine status is obtained from the health passport at household visits at 4 and 12 month of age or following death. Mchinji contributes to the population based cohort study listed above (study 5) and the primary endpoint of survival to 1 year. The site is coordinated by the Mai Mwana Project, with support from University College London.


Methods and challenges in measuring the impact of national pneumococcal and rotavirus vaccine introduction on morbidity and mortality in Malawi.

Bar-Zeev N, Kapanda L, King C, Beard J, Phiri T, Mvula H, Crampin AC, Mwansambo C, Costello A, Parashar U, Tate JE, Verani JR, Whitney CG, Heyderman RS, Cunliffe NA, French N, VacSurv Consorti - Vaccine (2015)

Structure of data flow for the Mchinji Mortality Cohort Study.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4441035&req=5

fig0010: Structure of data flow for the Mchinji Mortality Cohort Study.
Mentions: Central Malawi: Mchinji district population was 456,516 persons in the 2008 census, with an estimated live birth rate of 57 per 1000 population [32,33]. We conducted a baseline census of Mchinji district in March 2012. Ongoing prospective surveillance of over 2000 villages in the district is conducted for births and deaths or migration of children under 5 and women of child-bearing age. Village informants report vital events monthly, supported by enumerators, supervised by monitoring and evaluation officers (Fig. 2). Live births are followed to 1 year of age or death or emigration from the district. All deaths reported by informants are verified and cause of death determined by verbal autopsy. Vaccine status is obtained from the health passport at household visits at 4 and 12 month of age or following death. Mchinji contributes to the population based cohort study listed above (study 5) and the primary endpoint of survival to 1 year. The site is coordinated by the Mai Mwana Project, with support from University College London.

Bottom Line: Evaluating their effectiveness is vital to ensure optimal implementation and justify sustained investment.In the context of multiple population level interventions targeting study endpoints attribution of reduced incidence to vaccine impact may be flawed.Careful evaluation of vaccine effectiveness and impact in such settings is critical to sustaining support for vaccine programmes.

View Article: PubMed Central - PubMed

Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi; Institute of Infection & Global Health, University of Liverpool, Liverpool, UK. Electronic address: Naor.Bar-Zeev@liverpool.ac.uk.

No MeSH data available.


Related in: MedlinePlus