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A case of primary subpleural pulmonary microcystic myxoma coincidentally occurred with pulmonary adenocarcinoma.

Ahn J, Kim NR, Ha SY, Kim KW, Park KY, Sung YM - J Pathol Transl Med (2015)

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

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Myxoma occurs most commonly in the heart, which is regarded as the origin of primitive mesenchymal cells that differentiate into multiple tissues... Up to 18% of cardiac myxomas are located in the right atrium and are frequently diagnosed after recurrent pulmonary embolism... Extracardiac myxomas have been reported in the subcutaneous tissue, muscle, and lung... Cracking and a pleated pattern were observed on thickly smeared slides... Sparse capillaries were also found... Stellate cells with vacuolated bubbly cytoplasm were observed... Neither mitosis nor cytologic atypia was found in the stellate cells... Amorphous flocculent and granular proteinaceous material and some collagen fibrils were observed in the extracellular spaces... Macrophages, mature lymphocytes, and some mast cells were also found... No hyaline cartilaginous differentiation is seen... Mitoses are rarely found... Half of the cases presented with nonspecific symptoms; hemoptysis, dyspnea, shortness of breath, chest pain or exacerbation of underlying chronic obstructive pulmonary disease... The remaining lesions were found incidentally... Due to rarity and the subsequent lack of cumulative data on pulmonary microcystic myxoma, we suggest that cysts negative for both vascular markers and epithelial markers may be related to increased MMP activity in a microcystic variant of pulmonary myxoma, as in cardiac myxoma, showing excessive degradation of extracellular matrix and resulting in increased potential risk for metastatic embolism... Accumulating prospective data on MMP-2 and MMP-9 immunoreactivities in pulmonary myxomas is necessary in order to evaluate the prognostic correlation.

No MeSH data available.


Ultrastructural examination reveals spindle to round cells with round euchromatic nuclei and cytoplasm having many lysosomes, mitochondria, and rough endoplasmic reticulums. Extracellular amorphous mucin material (arrow) is observed (left, ×2,500). Multiple ruffled cell surfaces (thin arrow) and abundant collagen fibrils (thick arrow) are also observed (right, ×3,500).
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f3-jptm-49-3-274: Ultrastructural examination reveals spindle to round cells with round euchromatic nuclei and cytoplasm having many lysosomes, mitochondria, and rough endoplasmic reticulums. Extracellular amorphous mucin material (arrow) is observed (left, ×2,500). Multiple ruffled cell surfaces (thin arrow) and abundant collagen fibrils (thick arrow) are also observed (right, ×3,500).

Mentions: Ultrastructurally, the tumor was composed of several types of cells including spindle-shaped fibroblast-like cells (Fig. 3). The fibroblast-like spindle cells had a ruffled villus-like cell surface, and the cytoplasm was filled with rough endoplasmic reticulums, prominent Golgi complexes, and lysosomes. Amorphous flocculent and granular proteinaceous material and some collagen fibrils were observed in the extracellular spaces. Macrophages, mature lymphocytes, and some mast cells were also found. Cell junctions were not observed. Metastasis or embolic myxoma from the heart was excluded based on the absence of primary cardiac myxoma and the cytologic benignity of the pulmonary mass. Primary pulmonary myxoma was the diagnosis.


A case of primary subpleural pulmonary microcystic myxoma coincidentally occurred with pulmonary adenocarcinoma.

Ahn J, Kim NR, Ha SY, Kim KW, Park KY, Sung YM - J Pathol Transl Med (2015)

Ultrastructural examination reveals spindle to round cells with round euchromatic nuclei and cytoplasm having many lysosomes, mitochondria, and rough endoplasmic reticulums. Extracellular amorphous mucin material (arrow) is observed (left, ×2,500). Multiple ruffled cell surfaces (thin arrow) and abundant collagen fibrils (thick arrow) are also observed (right, ×3,500).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4440942&req=5

f3-jptm-49-3-274: Ultrastructural examination reveals spindle to round cells with round euchromatic nuclei and cytoplasm having many lysosomes, mitochondria, and rough endoplasmic reticulums. Extracellular amorphous mucin material (arrow) is observed (left, ×2,500). Multiple ruffled cell surfaces (thin arrow) and abundant collagen fibrils (thick arrow) are also observed (right, ×3,500).
Mentions: Ultrastructurally, the tumor was composed of several types of cells including spindle-shaped fibroblast-like cells (Fig. 3). The fibroblast-like spindle cells had a ruffled villus-like cell surface, and the cytoplasm was filled with rough endoplasmic reticulums, prominent Golgi complexes, and lysosomes. Amorphous flocculent and granular proteinaceous material and some collagen fibrils were observed in the extracellular spaces. Macrophages, mature lymphocytes, and some mast cells were also found. Cell junctions were not observed. Metastasis or embolic myxoma from the heart was excluded based on the absence of primary cardiac myxoma and the cytologic benignity of the pulmonary mass. Primary pulmonary myxoma was the diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Myxoma occurs most commonly in the heart, which is regarded as the origin of primitive mesenchymal cells that differentiate into multiple tissues... Up to 18% of cardiac myxomas are located in the right atrium and are frequently diagnosed after recurrent pulmonary embolism... Extracardiac myxomas have been reported in the subcutaneous tissue, muscle, and lung... Cracking and a pleated pattern were observed on thickly smeared slides... Sparse capillaries were also found... Stellate cells with vacuolated bubbly cytoplasm were observed... Neither mitosis nor cytologic atypia was found in the stellate cells... Amorphous flocculent and granular proteinaceous material and some collagen fibrils were observed in the extracellular spaces... Macrophages, mature lymphocytes, and some mast cells were also found... No hyaline cartilaginous differentiation is seen... Mitoses are rarely found... Half of the cases presented with nonspecific symptoms; hemoptysis, dyspnea, shortness of breath, chest pain or exacerbation of underlying chronic obstructive pulmonary disease... The remaining lesions were found incidentally... Due to rarity and the subsequent lack of cumulative data on pulmonary microcystic myxoma, we suggest that cysts negative for both vascular markers and epithelial markers may be related to increased MMP activity in a microcystic variant of pulmonary myxoma, as in cardiac myxoma, showing excessive degradation of extracellular matrix and resulting in increased potential risk for metastatic embolism... Accumulating prospective data on MMP-2 and MMP-9 immunoreactivities in pulmonary myxomas is necessary in order to evaluate the prognostic correlation.

No MeSH data available.