Limits...
A case of primary subpleural pulmonary microcystic myxoma coincidentally occurred with pulmonary adenocarcinoma.

Ahn J, Kim NR, Ha SY, Kim KW, Park KY, Sung YM - J Pathol Transl Med (2015)

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Myxoma occurs most commonly in the heart, which is regarded as the origin of primitive mesenchymal cells that differentiate into multiple tissues... Up to 18% of cardiac myxomas are located in the right atrium and are frequently diagnosed after recurrent pulmonary embolism... Extracardiac myxomas have been reported in the subcutaneous tissue, muscle, and lung... Cracking and a pleated pattern were observed on thickly smeared slides... Sparse capillaries were also found... Stellate cells with vacuolated bubbly cytoplasm were observed... Neither mitosis nor cytologic atypia was found in the stellate cells... Amorphous flocculent and granular proteinaceous material and some collagen fibrils were observed in the extracellular spaces... Macrophages, mature lymphocytes, and some mast cells were also found... No hyaline cartilaginous differentiation is seen... Mitoses are rarely found... Half of the cases presented with nonspecific symptoms; hemoptysis, dyspnea, shortness of breath, chest pain or exacerbation of underlying chronic obstructive pulmonary disease... The remaining lesions were found incidentally... Due to rarity and the subsequent lack of cumulative data on pulmonary microcystic myxoma, we suggest that cysts negative for both vascular markers and epithelial markers may be related to increased MMP activity in a microcystic variant of pulmonary myxoma, as in cardiac myxoma, showing excessive degradation of extracellular matrix and resulting in increased potential risk for metastatic embolism... Accumulating prospective data on MMP-2 and MMP-9 immunoreactivities in pulmonary myxomas is necessary in order to evaluate the prognostic correlation.

No MeSH data available.


(A) Precontrast chest computed tomography shows a well-delineated low-attenuated oval mass (arrow) with slightly high density delete the portion in the subpleural area. (B) Gross photo shows a well-demarcated ovoid mass (arrow) with a mucous gelatinous texture with focal hemorrhage.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4440942&req=5

f1-jptm-49-3-274: (A) Precontrast chest computed tomography shows a well-delineated low-attenuated oval mass (arrow) with slightly high density delete the portion in the subpleural area. (B) Gross photo shows a well-demarcated ovoid mass (arrow) with a mucous gelatinous texture with focal hemorrhage.

Mentions: A 71-year-old Korean man was admitted for an incidentally detected pulmonary mass. The initial chest X-ray and subsequent computed tomography (CT) showed a subpleurally located, well-defined, round and smooth mass in the left upper lobe, measuring 1.0×0.8×0.7 cm in size (Fig. 1A). The surrounding parenchyma showed mild volume loss and focal consolidation, measuring about 2.0×2.0×1.8 cm. A poorly enhanced soft tissue lesion, measuring 3.5×3.0×2.0 cm in size, was also found in the anterior thymic area. Cardiac echographic findings were as follows; normal-sized cardiac chambers, normal left ventricular systolic function, normal left ventricle filling pattern, and no motional abnormalities or regional wall abnormalities. Under the impression of pulmonary hamartoma, a wedge resection of the subpleural mass and partial thymectomy through video-assisted thoracoscopic surgery was performed. A 3-month follow up was planned for the parenchymal consolidation.


A case of primary subpleural pulmonary microcystic myxoma coincidentally occurred with pulmonary adenocarcinoma.

Ahn J, Kim NR, Ha SY, Kim KW, Park KY, Sung YM - J Pathol Transl Med (2015)

(A) Precontrast chest computed tomography shows a well-delineated low-attenuated oval mass (arrow) with slightly high density delete the portion in the subpleural area. (B) Gross photo shows a well-demarcated ovoid mass (arrow) with a mucous gelatinous texture with focal hemorrhage.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440942&req=5

f1-jptm-49-3-274: (A) Precontrast chest computed tomography shows a well-delineated low-attenuated oval mass (arrow) with slightly high density delete the portion in the subpleural area. (B) Gross photo shows a well-demarcated ovoid mass (arrow) with a mucous gelatinous texture with focal hemorrhage.
Mentions: A 71-year-old Korean man was admitted for an incidentally detected pulmonary mass. The initial chest X-ray and subsequent computed tomography (CT) showed a subpleurally located, well-defined, round and smooth mass in the left upper lobe, measuring 1.0×0.8×0.7 cm in size (Fig. 1A). The surrounding parenchyma showed mild volume loss and focal consolidation, measuring about 2.0×2.0×1.8 cm. A poorly enhanced soft tissue lesion, measuring 3.5×3.0×2.0 cm in size, was also found in the anterior thymic area. Cardiac echographic findings were as follows; normal-sized cardiac chambers, normal left ventricular systolic function, normal left ventricle filling pattern, and no motional abnormalities or regional wall abnormalities. Under the impression of pulmonary hamartoma, a wedge resection of the subpleural mass and partial thymectomy through video-assisted thoracoscopic surgery was performed. A 3-month follow up was planned for the parenchymal consolidation.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Myxoma occurs most commonly in the heart, which is regarded as the origin of primitive mesenchymal cells that differentiate into multiple tissues... Up to 18% of cardiac myxomas are located in the right atrium and are frequently diagnosed after recurrent pulmonary embolism... Extracardiac myxomas have been reported in the subcutaneous tissue, muscle, and lung... Cracking and a pleated pattern were observed on thickly smeared slides... Sparse capillaries were also found... Stellate cells with vacuolated bubbly cytoplasm were observed... Neither mitosis nor cytologic atypia was found in the stellate cells... Amorphous flocculent and granular proteinaceous material and some collagen fibrils were observed in the extracellular spaces... Macrophages, mature lymphocytes, and some mast cells were also found... No hyaline cartilaginous differentiation is seen... Mitoses are rarely found... Half of the cases presented with nonspecific symptoms; hemoptysis, dyspnea, shortness of breath, chest pain or exacerbation of underlying chronic obstructive pulmonary disease... The remaining lesions were found incidentally... Due to rarity and the subsequent lack of cumulative data on pulmonary microcystic myxoma, we suggest that cysts negative for both vascular markers and epithelial markers may be related to increased MMP activity in a microcystic variant of pulmonary myxoma, as in cardiac myxoma, showing excessive degradation of extracellular matrix and resulting in increased potential risk for metastatic embolism... Accumulating prospective data on MMP-2 and MMP-9 immunoreactivities in pulmonary myxomas is necessary in order to evaluate the prognostic correlation.

No MeSH data available.