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MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis.

Pyo JS, Sohn JH, Kang G, Kim DH, Kim K, Do IG, Kim DH - J Pathol Transl Med (2015)

Bottom Line: MUC2 expression was found in 58 of 167 GCs (34.7%).MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively).In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren's classification, pN stage, or pTNM stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background: While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinicopathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC).

Methods: The present study investigated the correlation between MUC2 expression and clinicopathological parameters in 167 human GCs. In addition, to confirm the clinicopathological significance of MUC2 expression, we performed a systematic review and meta-analysis in 1,832 GCs.

Results: MUC2 expression was found in 58 of 167 GCs (34.7%). MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively). However, MUC2 expression was not correlated with Lauren's classification and tumor differentiation. In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren's classification, pN stage, or pTNM stage.

Conclusions: MUC2 expression was correlated with a lower tumor depth and lower lymph node metastasis in our study; the meta-analysis showed a correlation of MUC2 expression with tumor differentiation and lower tumor depth.

No MeSH data available.


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Forest plot diagram for tumor differentiation (A) and Lauren’s classification (B). CI, confidence interval.
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f3-jptm-49-3-249: Forest plot diagram for tumor differentiation (A) and Lauren’s classification (B). CI, confidence interval.

Mentions: MUC2 expression was found in 827 of 1,832 GCs (45.1%), and the range in eligible studies was 22.9%–90.7% (Table 2). MUC2 expression was significantly correlated with tumor differentiation (OR, 1.303; 95% CI, 1.020 to 1.664; p=.034; I2=79.3%) (Fig. 3A) and lower tumor depth (pT1) (OR, 1.352; 95% CI, 1.055 to 1.734; p=.017; I2=65.7%) (Fig. 4A). However, Lauren’s classification was not correlated with MUC2 expression (OR, 1.245; 95% CI, 0.933 to 1.661; p=.137; I2=83.2%) (Fig. 3B), consistent with our immunohistochemical study. Unlike our result, meta-analysis showed no significant correlation between MUC2 expression and nodal stage or TNM stage (OR, 0.872; 95% CI, 0.689 to 1.104; p=.256; I2=68.4% and OR, 1.208; 95% CI, 0.940 to 1.552; p=.139; I2=21.3%, respectively) (Fig. 4B, C). Significant heterogeneities between studies were identified in tumor differentiation, Lauren’s classification, tumor depth and nodal stage but not TNM stage. In Begg’s funnel plots, no definite asymmetry was identified (data not shown). Moreover, Egger’s test showed no evidence of publication bias (Table 3) [1,3,8-16].


MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis.

Pyo JS, Sohn JH, Kang G, Kim DH, Kim K, Do IG, Kim DH - J Pathol Transl Med (2015)

Forest plot diagram for tumor differentiation (A) and Lauren’s classification (B). CI, confidence interval.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440937&req=5

f3-jptm-49-3-249: Forest plot diagram for tumor differentiation (A) and Lauren’s classification (B). CI, confidence interval.
Mentions: MUC2 expression was found in 827 of 1,832 GCs (45.1%), and the range in eligible studies was 22.9%–90.7% (Table 2). MUC2 expression was significantly correlated with tumor differentiation (OR, 1.303; 95% CI, 1.020 to 1.664; p=.034; I2=79.3%) (Fig. 3A) and lower tumor depth (pT1) (OR, 1.352; 95% CI, 1.055 to 1.734; p=.017; I2=65.7%) (Fig. 4A). However, Lauren’s classification was not correlated with MUC2 expression (OR, 1.245; 95% CI, 0.933 to 1.661; p=.137; I2=83.2%) (Fig. 3B), consistent with our immunohistochemical study. Unlike our result, meta-analysis showed no significant correlation between MUC2 expression and nodal stage or TNM stage (OR, 0.872; 95% CI, 0.689 to 1.104; p=.256; I2=68.4% and OR, 1.208; 95% CI, 0.940 to 1.552; p=.139; I2=21.3%, respectively) (Fig. 4B, C). Significant heterogeneities between studies were identified in tumor differentiation, Lauren’s classification, tumor depth and nodal stage but not TNM stage. In Begg’s funnel plots, no definite asymmetry was identified (data not shown). Moreover, Egger’s test showed no evidence of publication bias (Table 3) [1,3,8-16].

Bottom Line: MUC2 expression was found in 58 of 167 GCs (34.7%).MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively).In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren's classification, pN stage, or pTNM stage.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background: While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinicopathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC).

Methods: The present study investigated the correlation between MUC2 expression and clinicopathological parameters in 167 human GCs. In addition, to confirm the clinicopathological significance of MUC2 expression, we performed a systematic review and meta-analysis in 1,832 GCs.

Results: MUC2 expression was found in 58 of 167 GCs (34.7%). MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively). However, MUC2 expression was not correlated with Lauren's classification and tumor differentiation. In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren's classification, pN stage, or pTNM stage.

Conclusions: MUC2 expression was correlated with a lower tumor depth and lower lymph node metastasis in our study; the meta-analysis showed a correlation of MUC2 expression with tumor differentiation and lower tumor depth.

No MeSH data available.


Related in: MedlinePlus