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Pathology-MRI Correlation of Hepatocarcinogenesis: Recent Update.

Huh J, Kim KW, Kim J, Yu E - J Pathol Transl Med (2015)

Bottom Line: Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma.Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly enhanced our understanding of hepatocarcinogenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

ABSTRACT
Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma. Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly enhanced our understanding of hepatocarcinogenesis.

No MeSH data available.


Related in: MedlinePlus

Schematic view of multistep hepatocarcinogenesis. Unpaired arterial supply replaces portal supply progressively from regenerative nodules to progressed hepatocellular carcinoma (yellow, nodules with portal supply; red, nodules with unpaired arterial supply). Degrees of various pathologic components are depicted as gradient bars. DN, dysplastic nodule; HCC, hepatocellular carcinoma; HG, high grade; LG, low grade; RN, regenerative nodule.
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f1-jptm-49-3-218: Schematic view of multistep hepatocarcinogenesis. Unpaired arterial supply replaces portal supply progressively from regenerative nodules to progressed hepatocellular carcinoma (yellow, nodules with portal supply; red, nodules with unpaired arterial supply). Degrees of various pathologic components are depicted as gradient bars. DN, dysplastic nodule; HCC, hepatocellular carcinoma; HG, high grade; LG, low grade; RN, regenerative nodule.

Mentions: Multistep hepatocarcinogenesis is characterized by progressive dedifferentiation of phenotypically abnormal nodular lesions in the liver and the emergence of successively more advanced precancerous, early cancerous, and overtly cancerous lesions (Fig. 1) [7,8]. Chronic inflammation causes repeated injury to liver cells and regeneration of injured tissue, both of which promote accumulation of genetic and epigenetic alterations [9-12]. These alterations begin from the early preneoplastic phase and progress parallel to the evolution of hepatic fibrosis or cirrhosis [13,14].


Pathology-MRI Correlation of Hepatocarcinogenesis: Recent Update.

Huh J, Kim KW, Kim J, Yu E - J Pathol Transl Med (2015)

Schematic view of multistep hepatocarcinogenesis. Unpaired arterial supply replaces portal supply progressively from regenerative nodules to progressed hepatocellular carcinoma (yellow, nodules with portal supply; red, nodules with unpaired arterial supply). Degrees of various pathologic components are depicted as gradient bars. DN, dysplastic nodule; HCC, hepatocellular carcinoma; HG, high grade; LG, low grade; RN, regenerative nodule.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440933&req=5

f1-jptm-49-3-218: Schematic view of multistep hepatocarcinogenesis. Unpaired arterial supply replaces portal supply progressively from regenerative nodules to progressed hepatocellular carcinoma (yellow, nodules with portal supply; red, nodules with unpaired arterial supply). Degrees of various pathologic components are depicted as gradient bars. DN, dysplastic nodule; HCC, hepatocellular carcinoma; HG, high grade; LG, low grade; RN, regenerative nodule.
Mentions: Multistep hepatocarcinogenesis is characterized by progressive dedifferentiation of phenotypically abnormal nodular lesions in the liver and the emergence of successively more advanced precancerous, early cancerous, and overtly cancerous lesions (Fig. 1) [7,8]. Chronic inflammation causes repeated injury to liver cells and regeneration of injured tissue, both of which promote accumulation of genetic and epigenetic alterations [9-12]. These alterations begin from the early preneoplastic phase and progress parallel to the evolution of hepatic fibrosis or cirrhosis [13,14].

Bottom Line: Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma.Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly enhanced our understanding of hepatocarcinogenesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

ABSTRACT
Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma. Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly enhanced our understanding of hepatocarcinogenesis.

No MeSH data available.


Related in: MedlinePlus