Neural retina identity is specified by lens-derived BMP signals.
Bottom Line: Subsequently, our results provide evidence that a Rax2-positive eye-field state is not sufficient for the progress to a neural retina identity, but requires BMP signals.In addition, our results argue against any essential role of Wnt or FGF signals during the specification of neural retina cells, but provide evidence that Wnt signals together with BMP activity are sufficient to induce cells of retinal pigment epithelial character.We conclude that BMP activity emanating from the lens ectoderm maintains eye-field identity, inhibits telencephalic character and induces neural retina cells.
Affiliation: Umeå Centre for Molecular Medicine, Umeå University, Umeå 901 87, Sweden.Show MeSH
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Mentions: To examine when cells of the eye-field acquire neural retina character, we analyzed the generation of neural retina cells in relation to other eye and forebrain cells. To achieve this, the expression of a panel of markers was monitored in chick (Gallus gallus) embryos from stage 9 to stage 21 of development on consecutive sections (Fig. 1; supplementary material Fig. S1).Fig. 1.
Affiliation: Umeå Centre for Molecular Medicine, Umeå University, Umeå 901 87, Sweden.