Limits...
Broad-spectrum antiviral agents.

Zhu JD, Meng W, Wang XJ, Wang HC - Front Microbiol (2015)

Bottom Line: Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics.Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system.High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University Beijing, China.

ABSTRACT
Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics. This review discusses current knowledge, prospective applications, opportunities, and challenges in the development of broad-spectrum antiviral agents.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of targets for broad-spectrum antiviral agents. (a) Cathepsin L (b) gP120 (c) CD4 (d) six-helix bundle (e). N-glycan terminal mannose residues (f) hemagglutinin (g) sialic acid (h) protein Z (i) TSG101 (j) viral RNA polymerase (k) DHODH l. XPO1 → activate - l block. (1) 5705213 (2) PVP-coated nano-silver (3) HP-OVA (4) CV-N 5. eCD4Ig. (6) p20 (7) Griffithsin (8) CR6261 (9) DAS181 (10) FGI-104 (11) Compound 0013 (12) VL-01 (13) Bortezomib (14) MG132 (15) JMN3-003 (16) BCX4430. (17) Compound A3 (18) Cmp1 (19) KPT-335 (20) Antimycin A (21) BEZ-235. (22) Akt-IV (23) Rapamycin (24) DRACOs (25) 5′pppRNA (26) GSK983. (27) Compounds C1 and C2.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4440912&req=5

Figure 1: Schematic diagram of targets for broad-spectrum antiviral agents. (a) Cathepsin L (b) gP120 (c) CD4 (d) six-helix bundle (e). N-glycan terminal mannose residues (f) hemagglutinin (g) sialic acid (h) protein Z (i) TSG101 (j) viral RNA polymerase (k) DHODH l. XPO1 → activate - l block. (1) 5705213 (2) PVP-coated nano-silver (3) HP-OVA (4) CV-N 5. eCD4Ig. (6) p20 (7) Griffithsin (8) CR6261 (9) DAS181 (10) FGI-104 (11) Compound 0013 (12) VL-01 (13) Bortezomib (14) MG132 (15) JMN3-003 (16) BCX4430. (17) Compound A3 (18) Cmp1 (19) KPT-335 (20) Antimycin A (21) BEZ-235. (22) Akt-IV (23) Rapamycin (24) DRACOs (25) 5′pppRNA (26) GSK983. (27) Compounds C1 and C2.

Mentions: Current strategies of controlling viral infectivity focus on identification of agents capable of intervening in the essential steps for viral infection, including viral attachment, fusion/endocytosis, replication, assembly and budding in addition to drugs targeting viral envelope, as detailed in the following subsections, and in Table 1 and Figure 1.


Broad-spectrum antiviral agents.

Zhu JD, Meng W, Wang XJ, Wang HC - Front Microbiol (2015)

Schematic diagram of targets for broad-spectrum antiviral agents. (a) Cathepsin L (b) gP120 (c) CD4 (d) six-helix bundle (e). N-glycan terminal mannose residues (f) hemagglutinin (g) sialic acid (h) protein Z (i) TSG101 (j) viral RNA polymerase (k) DHODH l. XPO1 → activate - l block. (1) 5705213 (2) PVP-coated nano-silver (3) HP-OVA (4) CV-N 5. eCD4Ig. (6) p20 (7) Griffithsin (8) CR6261 (9) DAS181 (10) FGI-104 (11) Compound 0013 (12) VL-01 (13) Bortezomib (14) MG132 (15) JMN3-003 (16) BCX4430. (17) Compound A3 (18) Cmp1 (19) KPT-335 (20) Antimycin A (21) BEZ-235. (22) Akt-IV (23) Rapamycin (24) DRACOs (25) 5′pppRNA (26) GSK983. (27) Compounds C1 and C2.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440912&req=5

Figure 1: Schematic diagram of targets for broad-spectrum antiviral agents. (a) Cathepsin L (b) gP120 (c) CD4 (d) six-helix bundle (e). N-glycan terminal mannose residues (f) hemagglutinin (g) sialic acid (h) protein Z (i) TSG101 (j) viral RNA polymerase (k) DHODH l. XPO1 → activate - l block. (1) 5705213 (2) PVP-coated nano-silver (3) HP-OVA (4) CV-N 5. eCD4Ig. (6) p20 (7) Griffithsin (8) CR6261 (9) DAS181 (10) FGI-104 (11) Compound 0013 (12) VL-01 (13) Bortezomib (14) MG132 (15) JMN3-003 (16) BCX4430. (17) Compound A3 (18) Cmp1 (19) KPT-335 (20) Antimycin A (21) BEZ-235. (22) Akt-IV (23) Rapamycin (24) DRACOs (25) 5′pppRNA (26) GSK983. (27) Compounds C1 and C2.
Mentions: Current strategies of controlling viral infectivity focus on identification of agents capable of intervening in the essential steps for viral infection, including viral attachment, fusion/endocytosis, replication, assembly and budding in addition to drugs targeting viral envelope, as detailed in the following subsections, and in Table 1 and Figure 1.

Bottom Line: Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics.Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system.High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University Beijing, China.

ABSTRACT
Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics. This review discusses current knowledge, prospective applications, opportunities, and challenges in the development of broad-spectrum antiviral agents.

No MeSH data available.


Related in: MedlinePlus