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Catalytic mesoporous Janus nanomotors for active cargo delivery.

Ma X, Hahn K, Sanchez S - J. Am. Chem. Soc. (2015)

Bottom Line: The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %).Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion.Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

View Article: PubMed Central - PubMed

Affiliation: †Max Planck Institute for Intelligent Systems Institution, Heisenbergstraße 3, 70569 Stuttgart, Germany.

ABSTRACT
We report on the synergy between catalytic propulsion and mesoporous silica nanoparticles (MSNPs) for the design of Janus nanomotors as active cargo delivery systems with sizes <100 nm (40, 65, and 90 nm). The Janus asymmetry of the nanomotors is given by electron beam (e-beam) deposition of a very thin platinum (2 nm) layer on MSNPs. The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %). Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion. Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

No MeSH data available.


Related in: MedlinePlus

(a) Schematicillustration (left) and CLSM images of RhB loadedJMSNM(65 nm)@FITC-Pt, from left to right, are FITC channel, RhB channel,and overlay of bright field, FITC and RhB channels (scale bar is 75μm). (b) Schematic illustration of on-chip cargo delivery byJMSNM, and CLSM images of active diffused JMSNM taken after 0, 10,and 30 min from the location represented by the red box in the scheme.
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fig4: (a) Schematicillustration (left) and CLSM images of RhB loadedJMSNM(65 nm)@FITC-Pt, from left to right, are FITC channel, RhB channel,and overlay of bright field, FITC and RhB channels (scale bar is 75μm). (b) Schematic illustration of on-chip cargo delivery byJMSNM, and CLSM images of active diffused JMSNM taken after 0, 10,and 30 min from the location represented by the red box in the scheme.

Mentions: Mesoporous material based nanomotors are of significant interestbecause of their high porosity for cargo loading. To evaluate thatcapability, first fluorescein isothiocyanate (FITC), a green fluorescencedye, was used to label MSNP(65 nm) by covalent linkage (see the detailedprocedure in the Experimental Section in the SI) and then fabricate Janus nanomotors by further e-beam deposition,denoted as JMSNM(65 nm)@FITC-Pt. As illustrated in Figure 4a, the Rhodamine B (RhB) molecule was chosen asthe model drug with red fluorescence color. By stirring the JMSNM(65nm)@FITC-Pt in concentrated RhB aqueous solution for 24 h, RhB cargomolecules were loaded into the mesopores of the nanomotors via freediffusion. Then, RhB loaded JMSNP(65 nm)@FITC-Pt were observed byconfocal laser scanning microscopy (CLSM). The green dots indicatethe location of the JMSNP(65 nm)@FITC-Pt, overlapped with the reddots, suggesting the RhB cargo molecules were indeed loaded insidethe JMSNP(65 nm)@FITC-Pt (Figure 4a). A microchipcomprised of two reservoirs that were connected by a channel witha width of 100 μm was used for the active cargo transport investigation.


Catalytic mesoporous Janus nanomotors for active cargo delivery.

Ma X, Hahn K, Sanchez S - J. Am. Chem. Soc. (2015)

(a) Schematicillustration (left) and CLSM images of RhB loadedJMSNM(65 nm)@FITC-Pt, from left to right, are FITC channel, RhB channel,and overlay of bright field, FITC and RhB channels (scale bar is 75μm). (b) Schematic illustration of on-chip cargo delivery byJMSNM, and CLSM images of active diffused JMSNM taken after 0, 10,and 30 min from the location represented by the red box in the scheme.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440854&req=5

fig4: (a) Schematicillustration (left) and CLSM images of RhB loadedJMSNM(65 nm)@FITC-Pt, from left to right, are FITC channel, RhB channel,and overlay of bright field, FITC and RhB channels (scale bar is 75μm). (b) Schematic illustration of on-chip cargo delivery byJMSNM, and CLSM images of active diffused JMSNM taken after 0, 10,and 30 min from the location represented by the red box in the scheme.
Mentions: Mesoporous material based nanomotors are of significant interestbecause of their high porosity for cargo loading. To evaluate thatcapability, first fluorescein isothiocyanate (FITC), a green fluorescencedye, was used to label MSNP(65 nm) by covalent linkage (see the detailedprocedure in the Experimental Section in the SI) and then fabricate Janus nanomotors by further e-beam deposition,denoted as JMSNM(65 nm)@FITC-Pt. As illustrated in Figure 4a, the Rhodamine B (RhB) molecule was chosen asthe model drug with red fluorescence color. By stirring the JMSNM(65nm)@FITC-Pt in concentrated RhB aqueous solution for 24 h, RhB cargomolecules were loaded into the mesopores of the nanomotors via freediffusion. Then, RhB loaded JMSNP(65 nm)@FITC-Pt were observed byconfocal laser scanning microscopy (CLSM). The green dots indicatethe location of the JMSNP(65 nm)@FITC-Pt, overlapped with the reddots, suggesting the RhB cargo molecules were indeed loaded insidethe JMSNP(65 nm)@FITC-Pt (Figure 4a). A microchipcomprised of two reservoirs that were connected by a channel witha width of 100 μm was used for the active cargo transport investigation.

Bottom Line: The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %).Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion.Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

View Article: PubMed Central - PubMed

Affiliation: †Max Planck Institute for Intelligent Systems Institution, Heisenbergstraße 3, 70569 Stuttgart, Germany.

ABSTRACT
We report on the synergy between catalytic propulsion and mesoporous silica nanoparticles (MSNPs) for the design of Janus nanomotors as active cargo delivery systems with sizes <100 nm (40, 65, and 90 nm). The Janus asymmetry of the nanomotors is given by electron beam (e-beam) deposition of a very thin platinum (2 nm) layer on MSNPs. The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %). Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion. Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

No MeSH data available.


Related in: MedlinePlus