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Catalytic mesoporous Janus nanomotors for active cargo delivery.

Ma X, Hahn K, Sanchez S - J. Am. Chem. Soc. (2015)

Bottom Line: The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %).Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion.Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

View Article: PubMed Central - PubMed

Affiliation: †Max Planck Institute for Intelligent Systems Institution, Heisenbergstraße 3, 70569 Stuttgart, Germany.

ABSTRACT
We report on the synergy between catalytic propulsion and mesoporous silica nanoparticles (MSNPs) for the design of Janus nanomotors as active cargo delivery systems with sizes <100 nm (40, 65, and 90 nm). The Janus asymmetry of the nanomotors is given by electron beam (e-beam) deposition of a very thin platinum (2 nm) layer on MSNPs. The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %). Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion. Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

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Dynamics of catalytic JMSNMs by DLS measurements. (a)TEM-BF imageof JMSNM(65 nm) and schematic illustration (inset) of catalytic reactionproviding self-propulsion. Apparent diffusion coefficient of (b) JMSNMs-Pt(2nm), (c) MSNPs, and (d) comparison between JMSNM(65 nm)-Au(2 nm) andJMSNM(65 nm)-Pt(2 nm), with increasing H2O2 concentration.
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fig2: Dynamics of catalytic JMSNMs by DLS measurements. (a)TEM-BF imageof JMSNM(65 nm) and schematic illustration (inset) of catalytic reactionproviding self-propulsion. Apparent diffusion coefficient of (b) JMSNMs-Pt(2nm), (c) MSNPs, and (d) comparison between JMSNM(65 nm)-Au(2 nm) andJMSNM(65 nm)-Pt(2 nm), with increasing H2O2 concentration.

Mentions: Dynamic light scattering (DLS) was used to measure the apparentdiffusion coefficient of the JMSNM. As illustrated in Figure 2a, the Pt layer at one side triggers the decompositionof H2O2 into O2 and H2O. The propulsion force of JMSNM is mainly attributed to a self-diffusiophoresismechanism, where a chemical gradient is asymmetrically generated onboth sides by catalytic reactions.7,26,41,51 Upon increasing H2O2 fuel concentration, the apparent diffusion coefficientof JMSNM for the three sizes presents a growing trend and reachesa saturation plateau at a H2O2 concentrationof ∼2.5% wt (Figure 2b). For JMSNM(90nm)and JMSNM(65 nm), the diffusion coefficient value was enhancedby nearly 100%.


Catalytic mesoporous Janus nanomotors for active cargo delivery.

Ma X, Hahn K, Sanchez S - J. Am. Chem. Soc. (2015)

Dynamics of catalytic JMSNMs by DLS measurements. (a)TEM-BF imageof JMSNM(65 nm) and schematic illustration (inset) of catalytic reactionproviding self-propulsion. Apparent diffusion coefficient of (b) JMSNMs-Pt(2nm), (c) MSNPs, and (d) comparison between JMSNM(65 nm)-Au(2 nm) andJMSNM(65 nm)-Pt(2 nm), with increasing H2O2 concentration.
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4440854&req=5

fig2: Dynamics of catalytic JMSNMs by DLS measurements. (a)TEM-BF imageof JMSNM(65 nm) and schematic illustration (inset) of catalytic reactionproviding self-propulsion. Apparent diffusion coefficient of (b) JMSNMs-Pt(2nm), (c) MSNPs, and (d) comparison between JMSNM(65 nm)-Au(2 nm) andJMSNM(65 nm)-Pt(2 nm), with increasing H2O2 concentration.
Mentions: Dynamic light scattering (DLS) was used to measure the apparentdiffusion coefficient of the JMSNM. As illustrated in Figure 2a, the Pt layer at one side triggers the decompositionof H2O2 into O2 and H2O. The propulsion force of JMSNM is mainly attributed to a self-diffusiophoresismechanism, where a chemical gradient is asymmetrically generated onboth sides by catalytic reactions.7,26,41,51 Upon increasing H2O2 fuel concentration, the apparent diffusion coefficientof JMSNM for the three sizes presents a growing trend and reachesa saturation plateau at a H2O2 concentrationof ∼2.5% wt (Figure 2b). For JMSNM(90nm)and JMSNM(65 nm), the diffusion coefficient value was enhancedby nearly 100%.

Bottom Line: The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %).Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion.Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

View Article: PubMed Central - PubMed

Affiliation: †Max Planck Institute for Intelligent Systems Institution, Heisenbergstraße 3, 70569 Stuttgart, Germany.

ABSTRACT
We report on the synergy between catalytic propulsion and mesoporous silica nanoparticles (MSNPs) for the design of Janus nanomotors as active cargo delivery systems with sizes <100 nm (40, 65, and 90 nm). The Janus asymmetry of the nanomotors is given by electron beam (e-beam) deposition of a very thin platinum (2 nm) layer on MSNPs. The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %). Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion. Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

No MeSH data available.


Related in: MedlinePlus