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Interobserver agreement in detecting spectral-domain optical coherence tomography features of diabetic macular edema.

Heng LZ, Pefianaki M, Hykin P, Patel PJ - PLoS ONE (2015)

Bottom Line: Percentage concordance for SRF was 96% at all 3 regions analysed, whilst IRF was 96% at fovea and 98% at higher number of line-scans analysed.Concordance for MF was 100% at fovea and 98% at 1mm zone and whole scan with almost perfect and substantial κ respectively. κ agreement was substantial for VMT at all regions analysed.This finding is important as detection of macular fluid is used to guide retreatment with anti-angiogenic agents.

View Article: PubMed Central - PubMed

Affiliation: NIHR Moorfields Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.

ABSTRACT

Purpose: To evaluate interobserver agreement for the detection of spectral-domain optical coherence tomography (SDOCT) features of diabetic macular edema (DME).

Method: Cross-sectional study in which 2 retinal specialists evaluated SDOCT scans from eyes receiving treatment for DME. Scans from 50 eyes with DME of 39 patients were graded for features of DME including intra-retinal fluid (IRF), diffuse retinal oedema (DRE), hyper-reflective foci (HRF), subretinal fluid (SRF), macular fluid and vitreomacular traction (VMT). Features were graded as present or absent at zones involving the fovea, 1mm from the fovea and the whole scan of 49 line scans. Analysis was performed using cross-tabulations for percentage concordance and kappa values (κ).

Results: In the 2950 line scans analysed, there was an increase in percentage concordance for DRE and HRF when moving from a foveal line scan, 1mm zone and then to a whole scan analysis (88% vs 94% vs 96%) and (88% vs 94% vs 94%) respectively with κ ranging from substantial to almost perfect. Percentage concordance for SRF was 96% at all 3 regions analysed, whilst IRF was 96% at fovea and 98% at higher number of line-scans analysed. Concordance for MF was 100% at fovea and 98% at 1mm zone and whole scan with almost perfect and substantial κ respectively. κ agreement was substantial for VMT at all regions analysed.

Conclusion: We report a high level of interobserver agreement in the detection of SDOCT features of DME. This finding is important as detection of macular fluid is used to guide retreatment with anti-angiogenic agents.

No MeSH data available.


Related in: MedlinePlus

A single scan with macular fluid and Diffuse Retina Edema.Arrows points to the following features: a) Vitreomacular traction (VMT), b) Intraretinal Fluid (IRF); c) Subretinal Fluid (SRF), d) Hyper-reflective Foci (HRF).
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pone.0126557.g001: A single scan with macular fluid and Diffuse Retina Edema.Arrows points to the following features: a) Vitreomacular traction (VMT), b) Intraretinal Fluid (IRF); c) Subretinal Fluid (SRF), d) Hyper-reflective Foci (HRF).

Mentions: Two experienced retinal specialists certified as investigators in retina clinical trials involving OCT-based retreatment decisions (HLZ and MP) independently analysed line scans for the presence or absence of intraretinal fluid (IRF), diffuse retinal oedema (DRE), sub retinal fluid (SRF), macular fluid (MF), hyper-reflective foci (HRF) and vitreomacular traction (VMT) using standardized definitions (Table 1, Fig 1). These definitions were applied in a qualitative manner without reference to standard images. This was a deliberate effort to minimize standardization between the two observers, ensuring the results would be more translatable to clinical practice and investigator-determined retreatment decisions in DME clinical trials.


Interobserver agreement in detecting spectral-domain optical coherence tomography features of diabetic macular edema.

Heng LZ, Pefianaki M, Hykin P, Patel PJ - PLoS ONE (2015)

A single scan with macular fluid and Diffuse Retina Edema.Arrows points to the following features: a) Vitreomacular traction (VMT), b) Intraretinal Fluid (IRF); c) Subretinal Fluid (SRF), d) Hyper-reflective Foci (HRF).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440774&req=5

pone.0126557.g001: A single scan with macular fluid and Diffuse Retina Edema.Arrows points to the following features: a) Vitreomacular traction (VMT), b) Intraretinal Fluid (IRF); c) Subretinal Fluid (SRF), d) Hyper-reflective Foci (HRF).
Mentions: Two experienced retinal specialists certified as investigators in retina clinical trials involving OCT-based retreatment decisions (HLZ and MP) independently analysed line scans for the presence or absence of intraretinal fluid (IRF), diffuse retinal oedema (DRE), sub retinal fluid (SRF), macular fluid (MF), hyper-reflective foci (HRF) and vitreomacular traction (VMT) using standardized definitions (Table 1, Fig 1). These definitions were applied in a qualitative manner without reference to standard images. This was a deliberate effort to minimize standardization between the two observers, ensuring the results would be more translatable to clinical practice and investigator-determined retreatment decisions in DME clinical trials.

Bottom Line: Percentage concordance for SRF was 96% at all 3 regions analysed, whilst IRF was 96% at fovea and 98% at higher number of line-scans analysed.Concordance for MF was 100% at fovea and 98% at 1mm zone and whole scan with almost perfect and substantial κ respectively. κ agreement was substantial for VMT at all regions analysed.This finding is important as detection of macular fluid is used to guide retreatment with anti-angiogenic agents.

View Article: PubMed Central - PubMed

Affiliation: NIHR Moorfields Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.

ABSTRACT

Purpose: To evaluate interobserver agreement for the detection of spectral-domain optical coherence tomography (SDOCT) features of diabetic macular edema (DME).

Method: Cross-sectional study in which 2 retinal specialists evaluated SDOCT scans from eyes receiving treatment for DME. Scans from 50 eyes with DME of 39 patients were graded for features of DME including intra-retinal fluid (IRF), diffuse retinal oedema (DRE), hyper-reflective foci (HRF), subretinal fluid (SRF), macular fluid and vitreomacular traction (VMT). Features were graded as present or absent at zones involving the fovea, 1mm from the fovea and the whole scan of 49 line scans. Analysis was performed using cross-tabulations for percentage concordance and kappa values (κ).

Results: In the 2950 line scans analysed, there was an increase in percentage concordance for DRE and HRF when moving from a foveal line scan, 1mm zone and then to a whole scan analysis (88% vs 94% vs 96%) and (88% vs 94% vs 94%) respectively with κ ranging from substantial to almost perfect. Percentage concordance for SRF was 96% at all 3 regions analysed, whilst IRF was 96% at fovea and 98% at higher number of line-scans analysed. Concordance for MF was 100% at fovea and 98% at 1mm zone and whole scan with almost perfect and substantial κ respectively. κ agreement was substantial for VMT at all regions analysed.

Conclusion: We report a high level of interobserver agreement in the detection of SDOCT features of DME. This finding is important as detection of macular fluid is used to guide retreatment with anti-angiogenic agents.

No MeSH data available.


Related in: MedlinePlus