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Interleukin-8 for diagnosis of neonatal sepsis: a meta-analysis.

Zhou M, Cheng S, Yu J, Lu Q - PLoS ONE (2015)

Bottom Line: The diagnostic threshold analysis showed that there was no threshold effect.The meta-regression analysis showed the cut-off, QUADAS and onset time have no effect on the heterogeneity.However, we should combine the results with clinical symptoms and signs, laboratory and microbial results.

View Article: PubMed Central - PubMed

Affiliation: Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.

ABSTRACT

Background: Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity and mortality in neonates. Previous studies showed that interleukin 8 (IL-8) may effectively and rapidly diagnose NS.

Objective: We conducted the systematic review and meta-analysis to investigate the diagnostic value of the IL-8 in NS.

Methods: The literature was searched in PUBMED, EMBASE, Cochrane Library, CNKI, VIP and other Chinese Medical Databases during October 1998 to January 2014 using set search criteria. Each included study was evaluated by quality assessment of diagnostic accuracy studies tool. Two investigators independently extracted the data and study characteristics, and disagreements, if any, were resolved by consensus. Meta-disc software was used to calculate the pooled sensitivity, specificity and summary diagnostic odds ratio (SDOR), I² or Cochrane Q to test heterogeneity, and meta-regression to investigate the source of heterogeneity. Funnel plots were used to test the potential presence of publication bias. False-positive report probability (FPRP) was calculated to confirm the significance of the results.

Results: Eight studies (548 neonates) were included in this meta-analysis. The pooled sensitivity and specificity of IL-8 were 0.78 and 0.84, respectively, which had moderate accuracy in the diagnosis of NS. The pooled diagnostic odds ratio (DOR) and area under curve (AUC) was 21.64 and 0.8908 (Q*=0.8215), respectively. The diagnostic threshold analysis showed that there was no threshold effect. The meta-regression analysis showed the cut-off, QUADAS and onset time have no effect on the heterogeneity. The funnel plots showed the existence of publication bias.

Conclusion: Meta-analysis showed IL-8 had a moderate accuracy (AUC=0.8908) for the diagnosis of NS. IL-8 is a helpful biomarker for early diagnosis of NS. However, we should combine the results with clinical symptoms and signs, laboratory and microbial results.

No MeSH data available.


Related in: MedlinePlus

Forest plots of the pooled sensitivity and specificity of the IL-8 to diagnose NS.
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pone.0127170.g003: Forest plots of the pooled sensitivity and specificity of the IL-8 to diagnose NS.

Mentions: Eight articles met the inclusion criteria. The sensitivity ranged from 0.35 to 0.95 (pooled sensitivity: 0.78, 95% CI: 0.72 to 0.83); whereas specificity ranged from 0.67 to 1.00 (pooled specificity: 0.84, 95% CI: 0.79 to 0.88) (Fig 3). The present study found significant heterogeneity among studies (sensitivity, I2 = 83.7%; specificity, I2 = 85.1%), which indicated that might the study population; measure methods and other covariates were responsible for it.


Interleukin-8 for diagnosis of neonatal sepsis: a meta-analysis.

Zhou M, Cheng S, Yu J, Lu Q - PLoS ONE (2015)

Forest plots of the pooled sensitivity and specificity of the IL-8 to diagnose NS.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440704&req=5

pone.0127170.g003: Forest plots of the pooled sensitivity and specificity of the IL-8 to diagnose NS.
Mentions: Eight articles met the inclusion criteria. The sensitivity ranged from 0.35 to 0.95 (pooled sensitivity: 0.78, 95% CI: 0.72 to 0.83); whereas specificity ranged from 0.67 to 1.00 (pooled specificity: 0.84, 95% CI: 0.79 to 0.88) (Fig 3). The present study found significant heterogeneity among studies (sensitivity, I2 = 83.7%; specificity, I2 = 85.1%), which indicated that might the study population; measure methods and other covariates were responsible for it.

Bottom Line: The diagnostic threshold analysis showed that there was no threshold effect.The meta-regression analysis showed the cut-off, QUADAS and onset time have no effect on the heterogeneity.However, we should combine the results with clinical symptoms and signs, laboratory and microbial results.

View Article: PubMed Central - PubMed

Affiliation: Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.

ABSTRACT

Background: Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity and mortality in neonates. Previous studies showed that interleukin 8 (IL-8) may effectively and rapidly diagnose NS.

Objective: We conducted the systematic review and meta-analysis to investigate the diagnostic value of the IL-8 in NS.

Methods: The literature was searched in PUBMED, EMBASE, Cochrane Library, CNKI, VIP and other Chinese Medical Databases during October 1998 to January 2014 using set search criteria. Each included study was evaluated by quality assessment of diagnostic accuracy studies tool. Two investigators independently extracted the data and study characteristics, and disagreements, if any, were resolved by consensus. Meta-disc software was used to calculate the pooled sensitivity, specificity and summary diagnostic odds ratio (SDOR), I² or Cochrane Q to test heterogeneity, and meta-regression to investigate the source of heterogeneity. Funnel plots were used to test the potential presence of publication bias. False-positive report probability (FPRP) was calculated to confirm the significance of the results.

Results: Eight studies (548 neonates) were included in this meta-analysis. The pooled sensitivity and specificity of IL-8 were 0.78 and 0.84, respectively, which had moderate accuracy in the diagnosis of NS. The pooled diagnostic odds ratio (DOR) and area under curve (AUC) was 21.64 and 0.8908 (Q*=0.8215), respectively. The diagnostic threshold analysis showed that there was no threshold effect. The meta-regression analysis showed the cut-off, QUADAS and onset time have no effect on the heterogeneity. The funnel plots showed the existence of publication bias.

Conclusion: Meta-analysis showed IL-8 had a moderate accuracy (AUC=0.8908) for the diagnosis of NS. IL-8 is a helpful biomarker for early diagnosis of NS. However, we should combine the results with clinical symptoms and signs, laboratory and microbial results.

No MeSH data available.


Related in: MedlinePlus