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The papez circuit in first-episode, treatment-naive adults with major depressive disorder: combined atlas-based tract-specific quantification analysis and voxel-based analysis.

Jiang W, Gong G, Wu F, Kong L, Chen K, Cui W, Ren L, Fan G, Sun W, Ma H, Xu K, Tang Y, Wang F - PLoS ONE (2015)

Bottom Line: We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit).Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit.Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China; Department of Radiology, The Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, PR China.

ABSTRACT
Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with major depressive disorders and 34 healthy adult controls were compared. Our statistical approach compared structural integrity of 11 major white matter tracts between the major depressive disorder and adult controls, as well as illness duration influence in patients. Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit. Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages. Dysfunction of the Papez Circuit may be a potential marker for studying the pathogenesis of major depressive disorders.

No MeSH data available.


Related in: MedlinePlus

Compared with the HC group, the MDD group had lower FA values in the right anterior thalamic radiation in voxel-based diffusion tensor analysis (A: green; B: green in superimposed on WM tracts template).Abbreviation: HC, healthy control; MDD, major depressive disorder; FA, fractional anisotropy; WM, white matter.
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pone.0126673.g003: Compared with the HC group, the MDD group had lower FA values in the right anterior thalamic radiation in voxel-based diffusion tensor analysis (A: green; B: green in superimposed on WM tracts template).Abbreviation: HC, healthy control; MDD, major depressive disorder; FA, fractional anisotropy; WM, white matter.

Mentions: WM areas of the Papez circuit had lower FA values in the right parahippocampal gyrus (Fig 2), the right ATR (Fig 3), and the left anterior cingulate (Fig 4) (P<0.001, uncorrected). Lower FA values were also found in other brain regions (P<0.001, uncorrected): bilateral inferior frontal gyrus, right middle frontal gyrus, right middle occipital gyrus, right insula, and left caudate body. Table 3 lists all of the brain regions with statistically significantly reduced FA values for the MDD sample in contrast to the HC sample.


The papez circuit in first-episode, treatment-naive adults with major depressive disorder: combined atlas-based tract-specific quantification analysis and voxel-based analysis.

Jiang W, Gong G, Wu F, Kong L, Chen K, Cui W, Ren L, Fan G, Sun W, Ma H, Xu K, Tang Y, Wang F - PLoS ONE (2015)

Compared with the HC group, the MDD group had lower FA values in the right anterior thalamic radiation in voxel-based diffusion tensor analysis (A: green; B: green in superimposed on WM tracts template).Abbreviation: HC, healthy control; MDD, major depressive disorder; FA, fractional anisotropy; WM, white matter.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440648&req=5

pone.0126673.g003: Compared with the HC group, the MDD group had lower FA values in the right anterior thalamic radiation in voxel-based diffusion tensor analysis (A: green; B: green in superimposed on WM tracts template).Abbreviation: HC, healthy control; MDD, major depressive disorder; FA, fractional anisotropy; WM, white matter.
Mentions: WM areas of the Papez circuit had lower FA values in the right parahippocampal gyrus (Fig 2), the right ATR (Fig 3), and the left anterior cingulate (Fig 4) (P<0.001, uncorrected). Lower FA values were also found in other brain regions (P<0.001, uncorrected): bilateral inferior frontal gyrus, right middle frontal gyrus, right middle occipital gyrus, right insula, and left caudate body. Table 3 lists all of the brain regions with statistically significantly reduced FA values for the MDD sample in contrast to the HC sample.

Bottom Line: We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit).Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit.Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China; Department of Radiology, The Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, PR China.

ABSTRACT
Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with major depressive disorders and 34 healthy adult controls were compared. Our statistical approach compared structural integrity of 11 major white matter tracts between the major depressive disorder and adult controls, as well as illness duration influence in patients. Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit. Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages. Dysfunction of the Papez Circuit may be a potential marker for studying the pathogenesis of major depressive disorders.

No MeSH data available.


Related in: MedlinePlus