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Anodal tDCS over the Primary Motor Cortex Facilitates Long-Term Memory Formation Reflecting Use-Dependent Plasticity.

Rroji O, van Kuyck K, Nuttin B, Wenderoth N - PLoS ONE (2015)

Bottom Line: Our main result is that long term retention performance (i.e. 1 week after practice) was significantly better when practice was performed with anodal tDCS than with sham tDCS (p < 0.001).This effect was large (Cohen's d=1.01) and all but one subject followed the group trend.Our results support the notion that anodal tDCS facilitates synaptic plasticity mediated by an LTP-like mechanism, which is in accordance with previous research.

View Article: PubMed Central - PubMed

Affiliation: Department of Kinesiology, Research Center for Movement Control and Neuroplasticity, KU Leuven, Leuven, Belgium.

ABSTRACT
Previous research suggests that anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) modulates NMDA receptor dependent processes that mediate synaptic plasticity. Here we test this proposal by applying anodal versus sham tDCS while subjects practiced to flex the thumb as fast as possible (ballistic movements). Repetitive practice of this task has been shown to result in performance improvements that reflect use-dependent plasticity resulting from NMDA receptor mediated, long-term potentiation (LTP)-like processes. Using a double-blind within-subject cross-over design, subjects (n=14) participated either in an anodal or a sham tDCS session which were at least 3 months apart. Sham or anodal tDCS (1 mA) was applied for 20 min during motor practice and retention was tested 30 min, 24 hours and one week later. All subjects improved performance during each of the two sessions (p < 0.001) and learning gains were similar. Our main result is that long term retention performance (i.e. 1 week after practice) was significantly better when practice was performed with anodal tDCS than with sham tDCS (p < 0.001). This effect was large (Cohen's d=1.01) and all but one subject followed the group trend. Our data strongly suggest that anodal tDCS facilitates long-term memory formation reflecting use-dependent plasticity. Our results support the notion that anodal tDCS facilitates synaptic plasticity mediated by an LTP-like mechanism, which is in accordance with previous research.

No MeSH data available.


Related in: MedlinePlus

Significant session x order interaction.Individuals in the anodal—sham group (black, n = 7) exhibited larger performance improvements in the first than in the second session. By contrast, individuals in the sham—anodal group (gray, n = 7) exhibited smaller performance improvements in the first than in the second session. This finding lends further support to the observation that practice with anodal tDCS (solid bars) facilitated learning in comparison to sham tDCS (dotted bars). Data are shown as M ± SEM.
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pone.0127270.g005: Significant session x order interaction.Individuals in the anodal—sham group (black, n = 7) exhibited larger performance improvements in the first than in the second session. By contrast, individuals in the sham—anodal group (gray, n = 7) exhibited smaller performance improvements in the first than in the second session. This finding lends further support to the observation that practice with anodal tDCS (solid bars) facilitated learning in comparison to sham tDCS (dotted bars). Data are shown as M ± SEM.

Mentions: There was also a significant stimulation x order interaction effect (F(1,12) = 7.44, p = 0.018) that is the result of subjects in the anodal-sham group exhibiting larger overall performance improvements in the first than in the second session, while subjects in the sham-anodal group improved more in the second than in the first session (Fig 5). This confirms that differences in performance improvement between sessions resulted from the stimulation condition rather than from unspecific order effects.


Anodal tDCS over the Primary Motor Cortex Facilitates Long-Term Memory Formation Reflecting Use-Dependent Plasticity.

Rroji O, van Kuyck K, Nuttin B, Wenderoth N - PLoS ONE (2015)

Significant session x order interaction.Individuals in the anodal—sham group (black, n = 7) exhibited larger performance improvements in the first than in the second session. By contrast, individuals in the sham—anodal group (gray, n = 7) exhibited smaller performance improvements in the first than in the second session. This finding lends further support to the observation that practice with anodal tDCS (solid bars) facilitated learning in comparison to sham tDCS (dotted bars). Data are shown as M ± SEM.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440644&req=5

pone.0127270.g005: Significant session x order interaction.Individuals in the anodal—sham group (black, n = 7) exhibited larger performance improvements in the first than in the second session. By contrast, individuals in the sham—anodal group (gray, n = 7) exhibited smaller performance improvements in the first than in the second session. This finding lends further support to the observation that practice with anodal tDCS (solid bars) facilitated learning in comparison to sham tDCS (dotted bars). Data are shown as M ± SEM.
Mentions: There was also a significant stimulation x order interaction effect (F(1,12) = 7.44, p = 0.018) that is the result of subjects in the anodal-sham group exhibiting larger overall performance improvements in the first than in the second session, while subjects in the sham-anodal group improved more in the second than in the first session (Fig 5). This confirms that differences in performance improvement between sessions resulted from the stimulation condition rather than from unspecific order effects.

Bottom Line: Our main result is that long term retention performance (i.e. 1 week after practice) was significantly better when practice was performed with anodal tDCS than with sham tDCS (p < 0.001).This effect was large (Cohen's d=1.01) and all but one subject followed the group trend.Our results support the notion that anodal tDCS facilitates synaptic plasticity mediated by an LTP-like mechanism, which is in accordance with previous research.

View Article: PubMed Central - PubMed

Affiliation: Department of Kinesiology, Research Center for Movement Control and Neuroplasticity, KU Leuven, Leuven, Belgium.

ABSTRACT
Previous research suggests that anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) modulates NMDA receptor dependent processes that mediate synaptic plasticity. Here we test this proposal by applying anodal versus sham tDCS while subjects practiced to flex the thumb as fast as possible (ballistic movements). Repetitive practice of this task has been shown to result in performance improvements that reflect use-dependent plasticity resulting from NMDA receptor mediated, long-term potentiation (LTP)-like processes. Using a double-blind within-subject cross-over design, subjects (n=14) participated either in an anodal or a sham tDCS session which were at least 3 months apart. Sham or anodal tDCS (1 mA) was applied for 20 min during motor practice and retention was tested 30 min, 24 hours and one week later. All subjects improved performance during each of the two sessions (p < 0.001) and learning gains were similar. Our main result is that long term retention performance (i.e. 1 week after practice) was significantly better when practice was performed with anodal tDCS than with sham tDCS (p < 0.001). This effect was large (Cohen's d=1.01) and all but one subject followed the group trend. Our data strongly suggest that anodal tDCS facilitates long-term memory formation reflecting use-dependent plasticity. Our results support the notion that anodal tDCS facilitates synaptic plasticity mediated by an LTP-like mechanism, which is in accordance with previous research.

No MeSH data available.


Related in: MedlinePlus