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Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer.

Alexander DD, Bassett JK, Weed DL, Barrett EC, Watson H, Harris W - Nutr Cancer (2015)

Bottom Line: Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade.In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude.The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

View Article: PubMed Central - PubMed

Affiliation: a EpidStat Institute , Ann Arbor , Michigan , USA and Evergreen , Colorado , USA.

ABSTRACT
We conducted a systematic review and meta-analysis to estimate the potential association between LCω-3PUFAs and prostate cancer (PC). A comprehensive literature search was performed through 2013 to identify prospective studies that examined dietary intakes of long-chain omega-3 polyunsaturated fatty acids (LCω-3PUFA) or blood biomarkers of LCω-3PUFA status and risk of PC. Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade. Subgroup analyses were also conducted for specific fatty acids and other study characteristics. Twelve self-reported dietary intake and 9 biomarker studies from independent study populations were included in the analysis, with 446,243 and 14,897 total participants, respectively. No association between LCω-3PUFAs and total PC was observed (SRRE = 1.00, 95% CI: 0.93-1.09) for the dietary intake studies (high vs. low LCω-3PUFAs category comparison) or for the biomarker studies (SRRE of 1.07, 95% CI: 0.94-1.20). In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude. The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

No MeSH data available.


Related in: MedlinePlus

Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer by grade: biomarker studies.
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f0003: Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer by grade: biomarker studies.

Mentions: Nonsignificant inverse SRREs were observed for LCω-3PUFAs biomarkers and nonadvanced and advanced PC, although only 3 data points were analyzed for each model whereas nonsignificant positive SRREs were found for both low and high-grade PC (Table 2, Fig. 3).FIG. 3.


Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer.

Alexander DD, Bassett JK, Weed DL, Barrett EC, Watson H, Harris W - Nutr Cancer (2015)

Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer by grade: biomarker studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4440629&req=5

f0003: Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer by grade: biomarker studies.
Mentions: Nonsignificant inverse SRREs were observed for LCω-3PUFAs biomarkers and nonadvanced and advanced PC, although only 3 data points were analyzed for each model whereas nonsignificant positive SRREs were found for both low and high-grade PC (Table 2, Fig. 3).FIG. 3.

Bottom Line: Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade.In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude.The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

View Article: PubMed Central - PubMed

Affiliation: a EpidStat Institute , Ann Arbor , Michigan , USA and Evergreen , Colorado , USA.

ABSTRACT
We conducted a systematic review and meta-analysis to estimate the potential association between LCω-3PUFAs and prostate cancer (PC). A comprehensive literature search was performed through 2013 to identify prospective studies that examined dietary intakes of long-chain omega-3 polyunsaturated fatty acids (LCω-3PUFA) or blood biomarkers of LCω-3PUFA status and risk of PC. Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade. Subgroup analyses were also conducted for specific fatty acids and other study characteristics. Twelve self-reported dietary intake and 9 biomarker studies from independent study populations were included in the analysis, with 446,243 and 14,897 total participants, respectively. No association between LCω-3PUFAs and total PC was observed (SRRE = 1.00, 95% CI: 0.93-1.09) for the dietary intake studies (high vs. low LCω-3PUFAs category comparison) or for the biomarker studies (SRRE of 1.07, 95% CI: 0.94-1.20). In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude. The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

No MeSH data available.


Related in: MedlinePlus