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Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer.

Alexander DD, Bassett JK, Weed DL, Barrett EC, Watson H, Harris W - Nutr Cancer (2015)

Bottom Line: Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade.In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude.The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

View Article: PubMed Central - PubMed

Affiliation: a EpidStat Institute , Ann Arbor , Michigan , USA and Evergreen , Colorado , USA.

ABSTRACT
We conducted a systematic review and meta-analysis to estimate the potential association between LCω-3PUFAs and prostate cancer (PC). A comprehensive literature search was performed through 2013 to identify prospective studies that examined dietary intakes of long-chain omega-3 polyunsaturated fatty acids (LCω-3PUFA) or blood biomarkers of LCω-3PUFA status and risk of PC. Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade. Subgroup analyses were also conducted for specific fatty acids and other study characteristics. Twelve self-reported dietary intake and 9 biomarker studies from independent study populations were included in the analysis, with 446,243 and 14,897 total participants, respectively. No association between LCω-3PUFAs and total PC was observed (SRRE = 1.00, 95% CI: 0.93-1.09) for the dietary intake studies (high vs. low LCω-3PUFAs category comparison) or for the biomarker studies (SRRE of 1.07, 95% CI: 0.94-1.20). In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude. The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

No MeSH data available.


Related in: MedlinePlus

Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer: biomarker studies, overall and by follow-up duration.
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Related In: Results  -  Collection


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f0002: Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer: biomarker studies, overall and by follow-up duration.

Mentions: A nonsignificant SRRE was observed in the meta-analysis of 9 biomarker studies of LCω-3PUFAs (SRRE = 1.07, 95% CI: 0.94–1.20; p-H = 0.065) (Table 2, Fig. 2). A 1-study-removed meta-analysis was conducted to evaluate the relative influence that each study had on the overall model. Removal of each study had a negligible impact on the overall summary effect; however, removal of Chavarro et al. (39) resulted in a statistically significant SRRE of 1.11 (95% CI: 1.01–1.21). Visual inspection of funnel plots and Egger's regression method and the Duval and Tweedie imputation method did not indicate the presence of publication bias. No differences in summary associations were observed after stratifying by study country (Table 2).FIG. 2.


Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer.

Alexander DD, Bassett JK, Weed DL, Barrett EC, Watson H, Harris W - Nutr Cancer (2015)

Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer: biomarker studies, overall and by follow-up duration.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4440629&req=5

f0002: Omega-3 long chain-polyunsaturated fatty acids and total prostate cancer: biomarker studies, overall and by follow-up duration.
Mentions: A nonsignificant SRRE was observed in the meta-analysis of 9 biomarker studies of LCω-3PUFAs (SRRE = 1.07, 95% CI: 0.94–1.20; p-H = 0.065) (Table 2, Fig. 2). A 1-study-removed meta-analysis was conducted to evaluate the relative influence that each study had on the overall model. Removal of each study had a negligible impact on the overall summary effect; however, removal of Chavarro et al. (39) resulted in a statistically significant SRRE of 1.11 (95% CI: 1.01–1.21). Visual inspection of funnel plots and Egger's regression method and the Duval and Tweedie imputation method did not indicate the presence of publication bias. No differences in summary associations were observed after stratifying by study country (Table 2).FIG. 2.

Bottom Line: Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade.In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude.The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

View Article: PubMed Central - PubMed

Affiliation: a EpidStat Institute , Ann Arbor , Michigan , USA and Evergreen , Colorado , USA.

ABSTRACT
We conducted a systematic review and meta-analysis to estimate the potential association between LCω-3PUFAs and prostate cancer (PC). A comprehensive literature search was performed through 2013 to identify prospective studies that examined dietary intakes of long-chain omega-3 polyunsaturated fatty acids (LCω-3PUFA) or blood biomarkers of LCω-3PUFA status and risk of PC. Random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for LCω-3PUFAs and total PC, and by stage and grade. Subgroup analyses were also conducted for specific fatty acids and other study characteristics. Twelve self-reported dietary intake and 9 biomarker studies from independent study populations were included in the analysis, with 446,243 and 14,897 total participants, respectively. No association between LCω-3PUFAs and total PC was observed (SRRE = 1.00, 95% CI: 0.93-1.09) for the dietary intake studies (high vs. low LCω-3PUFAs category comparison) or for the biomarker studies (SRRE of 1.07, 95% CI: 0.94-1.20). In general, most summary associations for the dietary intake studies were in the inverse direction, whereas the majority of summary associations for the biomarker studies were in the positive direction, but all were weak in magnitude. The results from this meta-analysis do not support an association between LCω-3PUFAs and PC.

No MeSH data available.


Related in: MedlinePlus