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Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis.

Yuan X, Wu H, Xu H, Han N, Chu Q, Yu S, Chen Y, Wu K - Sci Rep (2015)

Bottom Line: The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages.Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%).Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, P.R. China.

ABSTRACT
Various studies have assessed the clinicopathological and prognostic value of Notch1 and Notch3 expression in Non-small cell lung cancer (NSCLC), but their results remain controversial. This meta-analysis was conducted to address the above issues by using a total of 19 studies involving 3663 patients. The correlations between Notch1 and Notch3 expression and clinicopathological features and NSCLC prognosis were analyzed. The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages. Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%). Furthermore, there are statistically significant association between overall survival of NSCLC patients and the expression of Notch signaling ligand DLL3 and target gene HES1. Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

No MeSH data available.


Related in: MedlinePlus

HES1 expression is correlated with overall survival of NSCLC patients(GSE31210). A. Overall survival rate was analyzed in 226 patients with NSCLC cancer, in relation to HES1 expression. B. Overall survival rate was analyzed in 127 patients with EGFR mutation+ NSCLC cancer, in relation to HES1 expression. C. Overall survival rate was analyzed in 68 patients with EGFR mutation- NSCLC cancer, in relation to HES1 expression.
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f7: HES1 expression is correlated with overall survival of NSCLC patients(GSE31210). A. Overall survival rate was analyzed in 226 patients with NSCLC cancer, in relation to HES1 expression. B. Overall survival rate was analyzed in 127 patients with EGFR mutation+ NSCLC cancer, in relation to HES1 expression. C. Overall survival rate was analyzed in 68 patients with EGFR mutation- NSCLC cancer, in relation to HES1 expression.

Mentions: Whole genomic expression profiles provide unbiased quantitative measure of mRNA abundance and have been proved to correlated with histo-pathological characteristics and predict prognosis24. To investigate whether HES1 mRNA abundance correlated with NSCLC survival, we analyzed published gene expression database of NSCLC with survival information. Kaplan –Meier survival curve of GSE31210 comprised of 226 NSCLC patients at stage I-II demonstrated that the overall survival rate was lower in patients with higher expression of HES1 (p = 0.007) (Fig. 7A). To explore whether mutation of EGFR interferes with HES1, NSCLC patients were subdivided into EGFR mutation and wild type (wt) group. The overall survival rate of patients with EGFR mutation was correlated with the abundance of HES1 expression (p = 0.008) (Fig. 7B). However, there is no statistical relation between HES1 expression and OS in EGFR wt patients (p = 0.244) (Fig. 7C). Together, analysis results from HES1 mRNA profile are in consisting with protein abundance, both indicating that higher Notch signaling activity predicts worse prognosis.


Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis.

Yuan X, Wu H, Xu H, Han N, Chu Q, Yu S, Chen Y, Wu K - Sci Rep (2015)

HES1 expression is correlated with overall survival of NSCLC patients(GSE31210). A. Overall survival rate was analyzed in 226 patients with NSCLC cancer, in relation to HES1 expression. B. Overall survival rate was analyzed in 127 patients with EGFR mutation+ NSCLC cancer, in relation to HES1 expression. C. Overall survival rate was analyzed in 68 patients with EGFR mutation- NSCLC cancer, in relation to HES1 expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440529&req=5

f7: HES1 expression is correlated with overall survival of NSCLC patients(GSE31210). A. Overall survival rate was analyzed in 226 patients with NSCLC cancer, in relation to HES1 expression. B. Overall survival rate was analyzed in 127 patients with EGFR mutation+ NSCLC cancer, in relation to HES1 expression. C. Overall survival rate was analyzed in 68 patients with EGFR mutation- NSCLC cancer, in relation to HES1 expression.
Mentions: Whole genomic expression profiles provide unbiased quantitative measure of mRNA abundance and have been proved to correlated with histo-pathological characteristics and predict prognosis24. To investigate whether HES1 mRNA abundance correlated with NSCLC survival, we analyzed published gene expression database of NSCLC with survival information. Kaplan –Meier survival curve of GSE31210 comprised of 226 NSCLC patients at stage I-II demonstrated that the overall survival rate was lower in patients with higher expression of HES1 (p = 0.007) (Fig. 7A). To explore whether mutation of EGFR interferes with HES1, NSCLC patients were subdivided into EGFR mutation and wild type (wt) group. The overall survival rate of patients with EGFR mutation was correlated with the abundance of HES1 expression (p = 0.008) (Fig. 7B). However, there is no statistical relation between HES1 expression and OS in EGFR wt patients (p = 0.244) (Fig. 7C). Together, analysis results from HES1 mRNA profile are in consisting with protein abundance, both indicating that higher Notch signaling activity predicts worse prognosis.

Bottom Line: The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages.Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%).Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, P.R. China.

ABSTRACT
Various studies have assessed the clinicopathological and prognostic value of Notch1 and Notch3 expression in Non-small cell lung cancer (NSCLC), but their results remain controversial. This meta-analysis was conducted to address the above issues by using a total of 19 studies involving 3663 patients. The correlations between Notch1 and Notch3 expression and clinicopathological features and NSCLC prognosis were analyzed. The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages. Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%). Furthermore, there are statistically significant association between overall survival of NSCLC patients and the expression of Notch signaling ligand DLL3 and target gene HES1. Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

No MeSH data available.


Related in: MedlinePlus