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Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis.

Yuan X, Wu H, Xu H, Han N, Chu Q, Yu S, Chen Y, Wu K - Sci Rep (2015)

Bottom Line: The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages.Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%).Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, P.R. China.

ABSTRACT
Various studies have assessed the clinicopathological and prognostic value of Notch1 and Notch3 expression in Non-small cell lung cancer (NSCLC), but their results remain controversial. This meta-analysis was conducted to address the above issues by using a total of 19 studies involving 3663 patients. The correlations between Notch1 and Notch3 expression and clinicopathological features and NSCLC prognosis were analyzed. The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages. Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%). Furthermore, there are statistically significant association between overall survival of NSCLC patients and the expression of Notch signaling ligand DLL3 and target gene HES1. Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

No MeSH data available.


Related in: MedlinePlus

Forest plot of hazard ratio (HR). CI, confidence interval. A. Association between DLL4 and NSCLC OS. B. Association between DLL4 and ADC OS. C. Association between DLL4 and SCC OS.
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f5: Forest plot of hazard ratio (HR). CI, confidence interval. A. Association between DLL4 and NSCLC OS. B. Association between DLL4 and ADC OS. C. Association between DLL4 and SCC OS.

Mentions: Notch signaling is initiated by ligand binding to Notch receptor; therefore, we further analyzed expressions of Notch ligands and prognosis of NSCLC patients. As shown in Fig. 5, a statistically significant association between DLL4 expression and NSCLC overall survival rate was found (NSCLC: pooled HR = 1.60, 95%CI: 1.18-2.17, p = 0.547 and I2 = 0.0%; lung adenocarcinoma: pooled HR = 1.66, 95%CI: 1.10-2.50, p = 0.206 and I2 = 36.7%; lung squamous cell carcinoma: pooled HR = 2.56, 95%CI: 1.56-4.19, p = 0.169 and I2 = 47%). However, there was no significant relation between the expressions of DLL1 and DLL3 and overall survival of NSCLC patients.


Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis.

Yuan X, Wu H, Xu H, Han N, Chu Q, Yu S, Chen Y, Wu K - Sci Rep (2015)

Forest plot of hazard ratio (HR). CI, confidence interval. A. Association between DLL4 and NSCLC OS. B. Association between DLL4 and ADC OS. C. Association between DLL4 and SCC OS.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440529&req=5

f5: Forest plot of hazard ratio (HR). CI, confidence interval. A. Association between DLL4 and NSCLC OS. B. Association between DLL4 and ADC OS. C. Association between DLL4 and SCC OS.
Mentions: Notch signaling is initiated by ligand binding to Notch receptor; therefore, we further analyzed expressions of Notch ligands and prognosis of NSCLC patients. As shown in Fig. 5, a statistically significant association between DLL4 expression and NSCLC overall survival rate was found (NSCLC: pooled HR = 1.60, 95%CI: 1.18-2.17, p = 0.547 and I2 = 0.0%; lung adenocarcinoma: pooled HR = 1.66, 95%CI: 1.10-2.50, p = 0.206 and I2 = 36.7%; lung squamous cell carcinoma: pooled HR = 2.56, 95%CI: 1.56-4.19, p = 0.169 and I2 = 47%). However, there was no significant relation between the expressions of DLL1 and DLL3 and overall survival of NSCLC patients.

Bottom Line: The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages.Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%).Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, P.R. China.

ABSTRACT
Various studies have assessed the clinicopathological and prognostic value of Notch1 and Notch3 expression in Non-small cell lung cancer (NSCLC), but their results remain controversial. This meta-analysis was conducted to address the above issues by using a total of 19 studies involving 3663 patients. The correlations between Notch1 and Notch3 expression and clinicopathological features and NSCLC prognosis were analyzed. The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages. Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%). Furthermore, there are statistically significant association between overall survival of NSCLC patients and the expression of Notch signaling ligand DLL3 and target gene HES1. Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.

No MeSH data available.


Related in: MedlinePlus