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Bone geometry of the hip is associated with obesity and early structural damage--a 3.0 T magnetic resonance imaging study of community-based adults.

Teichtahl AJ, Wang Y, Smith S, Wluka AE, Zhu M, Urquhart D, Giles GG, O'Sullivan R, Cicuttini FM - Arthritis Res. Ther. (2015)

Bottom Line: Obesity is associated with acetabular over-coverage.Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions.Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.

ABSTRACT

Introduction: The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions.

Methods: One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010.

Results: Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure.

Conclusions: Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

No MeSH data available.


Related in: MedlinePlus

Regional zones of the hip joint.
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Fig3: Regional zones of the hip joint.

Mentions: The femoral head was divided into three regions (central, anterior and posterior) to assess cartilage defects and BMLs. The anterior and posterior regions were assessed in the sagittal plane and corresponded to the first and last three coronal slices (9 mm) (Figure 3). The area in between the anterior and posterior region was termed the central region. The division of anterior, central and posterior regions was adapted from methods used in previously published works [21,22].Figure 3


Bone geometry of the hip is associated with obesity and early structural damage--a 3.0 T magnetic resonance imaging study of community-based adults.

Teichtahl AJ, Wang Y, Smith S, Wluka AE, Zhu M, Urquhart D, Giles GG, O'Sullivan R, Cicuttini FM - Arthritis Res. Ther. (2015)

Regional zones of the hip joint.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4440504&req=5

Fig3: Regional zones of the hip joint.
Mentions: The femoral head was divided into three regions (central, anterior and posterior) to assess cartilage defects and BMLs. The anterior and posterior regions were assessed in the sagittal plane and corresponded to the first and last three coronal slices (9 mm) (Figure 3). The area in between the anterior and posterior region was termed the central region. The division of anterior, central and posterior regions was adapted from methods used in previously published works [21,22].Figure 3

Bottom Line: Obesity is associated with acetabular over-coverage.Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions.Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.

ABSTRACT

Introduction: The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions.

Methods: One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010.

Results: Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure.

Conclusions: Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

No MeSH data available.


Related in: MedlinePlus