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Bone geometry of the hip is associated with obesity and early structural damage--a 3.0 T magnetic resonance imaging study of community-based adults.

Teichtahl AJ, Wang Y, Smith S, Wluka AE, Zhu M, Urquhart D, Giles GG, O'Sullivan R, Cicuttini FM - Arthritis Res. Ther. (2015)

Bottom Line: Obesity is associated with acetabular over-coverage.Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions.Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.

ABSTRACT

Introduction: The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions.

Methods: One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010.

Results: Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure.

Conclusions: Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

No MeSH data available.


Related in: MedlinePlus

Lateral centre edge angle.
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Fig2: Lateral centre edge angle.

Mentions: LCEA was measured from a re-formatted coronal image using the same methods as for radiographs [25]. LCEA was the angle formed by the line from the lateral acetabular rim to the central point of the femoral head, and the vertical line through the central point of the femoral head (see Figure 2). The intra-observer reproducibility (assessed by ICC) was 0.87.Figure 2


Bone geometry of the hip is associated with obesity and early structural damage--a 3.0 T magnetic resonance imaging study of community-based adults.

Teichtahl AJ, Wang Y, Smith S, Wluka AE, Zhu M, Urquhart D, Giles GG, O'Sullivan R, Cicuttini FM - Arthritis Res. Ther. (2015)

Lateral centre edge angle.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4440504&req=5

Fig2: Lateral centre edge angle.
Mentions: LCEA was measured from a re-formatted coronal image using the same methods as for radiographs [25]. LCEA was the angle formed by the line from the lateral acetabular rim to the central point of the femoral head, and the vertical line through the central point of the femoral head (see Figure 2). The intra-observer reproducibility (assessed by ICC) was 0.87.Figure 2

Bottom Line: Obesity is associated with acetabular over-coverage.Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions.Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.

ABSTRACT

Introduction: The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions.

Methods: One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010.

Results: Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure.

Conclusions: Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.

No MeSH data available.


Related in: MedlinePlus