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The first Malay database toward the ethnic-specific target molecular variation.

Halim-Fikri H, Etemad A, Abdul Latif AZ, Merican AF, Baig AA, Annuar AA, Ismail E, Salahshourifar I, Liza-Sharmini AT, Ramli M, Shah MI, Johan MF, Hassan NN, Abdul-Aziz NM, Mohd Noor NH, Nur-Shafawati AR, Hassan R, Bahar R, Zain RB, Yusoff SM, Yusoff S, Tan SG, Thong MK, Wan-Isa H, Abdullah WZ, Mohamed Z, Abdul Latiff Z, Zilfalil BA, members of the Malaysian Node of the Human Variome Proje - BMC Res Notes (2015)

Bottom Line: Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project.A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups.Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. halimfikri@gmail.com.

ABSTRACT

Background: The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb).

Findings: Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ).

Conclusions: This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.

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Related in: MedlinePlus

Schematic Representation of the Architecture of Malayasian Node of the Human Variome Project Database (MyHVPDb).
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Fig3: Schematic Representation of the Architecture of Malayasian Node of the Human Variome Project Database (MyHVPDb).

Mentions: Additionally, the content and structure of MyHVPDb follows guidelines given by NCBI SNPs Database (http://www.ncbi.nlm.nih.gov/projects/SNP/). The overall design of MyHVPDb was based on three-tier architecture model (client, web and database) as shown in FigureĀ 3. The database was developed using Hypertext Markup Language (HTML), Cascading Style Sheet (CSS), Java Script, Hypertext Preprocessor (PHP) and Structured Query Language (SQL). PHP scripts were used as a Common Gateway Interface (CGI) for sending and receiving data between the front end user/client and the database server. To query data, users need to enter or choose a keyword such as SNP ID or chromosome number. The Apache web server will then transform the query into SQL for it to be requested from MySQL database.Figure 3


The first Malay database toward the ethnic-specific target molecular variation.

Halim-Fikri H, Etemad A, Abdul Latif AZ, Merican AF, Baig AA, Annuar AA, Ismail E, Salahshourifar I, Liza-Sharmini AT, Ramli M, Shah MI, Johan MF, Hassan NN, Abdul-Aziz NM, Mohd Noor NH, Nur-Shafawati AR, Hassan R, Bahar R, Zain RB, Yusoff SM, Yusoff S, Tan SG, Thong MK, Wan-Isa H, Abdullah WZ, Mohamed Z, Abdul Latiff Z, Zilfalil BA, members of the Malaysian Node of the Human Variome Proje - BMC Res Notes (2015)

Schematic Representation of the Architecture of Malayasian Node of the Human Variome Project Database (MyHVPDb).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4440489&req=5

Fig3: Schematic Representation of the Architecture of Malayasian Node of the Human Variome Project Database (MyHVPDb).
Mentions: Additionally, the content and structure of MyHVPDb follows guidelines given by NCBI SNPs Database (http://www.ncbi.nlm.nih.gov/projects/SNP/). The overall design of MyHVPDb was based on three-tier architecture model (client, web and database) as shown in FigureĀ 3. The database was developed using Hypertext Markup Language (HTML), Cascading Style Sheet (CSS), Java Script, Hypertext Preprocessor (PHP) and Structured Query Language (SQL). PHP scripts were used as a Common Gateway Interface (CGI) for sending and receiving data between the front end user/client and the database server. To query data, users need to enter or choose a keyword such as SNP ID or chromosome number. The Apache web server will then transform the query into SQL for it to be requested from MySQL database.Figure 3

Bottom Line: Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project.A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups.Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. halimfikri@gmail.com.

ABSTRACT

Background: The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb).

Findings: Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ).

Conclusions: This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.

Show MeSH
Related in: MedlinePlus