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The first Malay database toward the ethnic-specific target molecular variation.

Halim-Fikri H, Etemad A, Abdul Latif AZ, Merican AF, Baig AA, Annuar AA, Ismail E, Salahshourifar I, Liza-Sharmini AT, Ramli M, Shah MI, Johan MF, Hassan NN, Abdul-Aziz NM, Mohd Noor NH, Nur-Shafawati AR, Hassan R, Bahar R, Zain RB, Yusoff SM, Yusoff S, Tan SG, Thong MK, Wan-Isa H, Abdullah WZ, Mohamed Z, Abdul Latiff Z, Zilfalil BA, members of the Malaysian Node of the Human Variome Proje - BMC Res Notes (2015)

Bottom Line: Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project.A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups.Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. halimfikri@gmail.com.

ABSTRACT

Background: The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb).

Findings: Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ).

Conclusions: This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.

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Related in: MedlinePlus

The Ethnics(rectangle green) and Sub-ethnic Groups (rectangle yellow green in Malaysia.
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Fig1: The Ethnics(rectangle green) and Sub-ethnic Groups (rectangle yellow green in Malaysia.

Mentions: Malaysia is located in Southeast Asia and separated into two regions by the South China Sea, namely Peninsular Malaysia and East Malaysia (the latter is composed of Sabah and Sarawak). It has land borders with Thailand, Indonesia and Brunei also, maritime borders with Singapore, Vietnam and the Philippines. Malaysia is a multi-ethnic country with three major ethnic groups (Malay, Chinese and Indian); aborigines (Orang Asli which consist of Proto Malays, Negrito and Senoi); Sabahans and Sarawakian (Major sub-ethnic groups of Sabahan are Kadazan/Dusun, Bajau and Murut; followed by urban, Bidayuh and Melanau respectively as Major sub-ethnic groups of Sarawakian). Each ethnic group is further divided into sub-ethnic groups, representing the existing diversity of Malaysian population (Figure 1). The total population is 28.3 million, where Malays comprised 63% of the total population, followed by Chinese (28%), Indians (8%), and other ethnic groups (1%) [9].Figure 1


The first Malay database toward the ethnic-specific target molecular variation.

Halim-Fikri H, Etemad A, Abdul Latif AZ, Merican AF, Baig AA, Annuar AA, Ismail E, Salahshourifar I, Liza-Sharmini AT, Ramli M, Shah MI, Johan MF, Hassan NN, Abdul-Aziz NM, Mohd Noor NH, Nur-Shafawati AR, Hassan R, Bahar R, Zain RB, Yusoff SM, Yusoff S, Tan SG, Thong MK, Wan-Isa H, Abdullah WZ, Mohamed Z, Abdul Latiff Z, Zilfalil BA, members of the Malaysian Node of the Human Variome Proje - BMC Res Notes (2015)

The Ethnics(rectangle green) and Sub-ethnic Groups (rectangle yellow green in Malaysia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4440489&req=5

Fig1: The Ethnics(rectangle green) and Sub-ethnic Groups (rectangle yellow green in Malaysia.
Mentions: Malaysia is located in Southeast Asia and separated into two regions by the South China Sea, namely Peninsular Malaysia and East Malaysia (the latter is composed of Sabah and Sarawak). It has land borders with Thailand, Indonesia and Brunei also, maritime borders with Singapore, Vietnam and the Philippines. Malaysia is a multi-ethnic country with three major ethnic groups (Malay, Chinese and Indian); aborigines (Orang Asli which consist of Proto Malays, Negrito and Senoi); Sabahans and Sarawakian (Major sub-ethnic groups of Sabahan are Kadazan/Dusun, Bajau and Murut; followed by urban, Bidayuh and Melanau respectively as Major sub-ethnic groups of Sarawakian). Each ethnic group is further divided into sub-ethnic groups, representing the existing diversity of Malaysian population (Figure 1). The total population is 28.3 million, where Malays comprised 63% of the total population, followed by Chinese (28%), Indians (8%), and other ethnic groups (1%) [9].Figure 1

Bottom Line: Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project.A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups.Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. halimfikri@gmail.com.

ABSTRACT

Background: The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb).

Findings: Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ).

Conclusions: This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.

Show MeSH
Related in: MedlinePlus