Limits...
Influenza virus vaccination and kidney graft rejection: causality or coincidence.

Fischer AS, Møller BK, Krag S, Jespersen B - Clin Kidney J (2015)

Bottom Line: They all had different native diseases and were all vaccinated in the same season of 2009-10.The time span from vaccination to decline of kidney function is shorter than the time to diagnosis since the three patients only had blood tests every 3 months or when symptoms became severe.These reports do not justify a change of current recommendations regarding influenza vaccination in renal transplant recipients, but they support the continued attention and registration of vaccinations to monitor side effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology , Aarhus University Hospital, Skejby , Århus N DK-8200 , Denmark.

ABSTRACT
Influenza can cause significant morbidity and mortality in renal transplant recipients especially with a high rate of lower respiratory disease. Annual influenza vaccination is therefore recommended to renal transplant recipients. We report the first three cases of acute kidney injury in renal transplant recipients following influenza vaccination that all led to graft loss. They all had different native diseases and were all vaccinated in the same season of 2009-10. The time span from vaccination to decline of kidney function is shorter than the time to diagnosis since the three patients only had blood tests every 3 months or when symptoms became severe. These reports do not justify a change of current recommendations regarding influenza vaccination in renal transplant recipients, but they support the continued attention and registration of vaccinations to monitor side effects.

No MeSH data available.


Related in: MedlinePlus

Kidney biopsy of Case 2.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4440474&req=5

SFV027F1: Kidney biopsy of Case 2.

Mentions: Symptoms started right after the vaccination, and at admission, she complained of flu-like symptoms, shortness of breath, swelling of her face and lower limbs, joint pain in her right ankle and was found to have an elevated plasma creatinine of 227 µmol/L. Urine protein was 1.58 g/L. Ultrasound showed no urinary obstruction, and there were no signs of infection. Renal biopsy revealed signs of both acute and chronic humoral rejection with peritubular capillaritis and positive C4d staining as well as signs of transplant glomerulopathy (Figure 1). Flow cytometric crossmatching was positive. She was treated with intravenous (IV) high-dose methylprednisolone 500 mg daily for 3 days, 7 days of plasmapheresis, IV immunoglobulin and two courses of 750 mg rituximab, but neither had effect on graft function.Fig. 1.


Influenza virus vaccination and kidney graft rejection: causality or coincidence.

Fischer AS, Møller BK, Krag S, Jespersen B - Clin Kidney J (2015)

Kidney biopsy of Case 2.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440474&req=5

SFV027F1: Kidney biopsy of Case 2.
Mentions: Symptoms started right after the vaccination, and at admission, she complained of flu-like symptoms, shortness of breath, swelling of her face and lower limbs, joint pain in her right ankle and was found to have an elevated plasma creatinine of 227 µmol/L. Urine protein was 1.58 g/L. Ultrasound showed no urinary obstruction, and there were no signs of infection. Renal biopsy revealed signs of both acute and chronic humoral rejection with peritubular capillaritis and positive C4d staining as well as signs of transplant glomerulopathy (Figure 1). Flow cytometric crossmatching was positive. She was treated with intravenous (IV) high-dose methylprednisolone 500 mg daily for 3 days, 7 days of plasmapheresis, IV immunoglobulin and two courses of 750 mg rituximab, but neither had effect on graft function.Fig. 1.

Bottom Line: They all had different native diseases and were all vaccinated in the same season of 2009-10.The time span from vaccination to decline of kidney function is shorter than the time to diagnosis since the three patients only had blood tests every 3 months or when symptoms became severe.These reports do not justify a change of current recommendations regarding influenza vaccination in renal transplant recipients, but they support the continued attention and registration of vaccinations to monitor side effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology , Aarhus University Hospital, Skejby , Århus N DK-8200 , Denmark.

ABSTRACT
Influenza can cause significant morbidity and mortality in renal transplant recipients especially with a high rate of lower respiratory disease. Annual influenza vaccination is therefore recommended to renal transplant recipients. We report the first three cases of acute kidney injury in renal transplant recipients following influenza vaccination that all led to graft loss. They all had different native diseases and were all vaccinated in the same season of 2009-10. The time span from vaccination to decline of kidney function is shorter than the time to diagnosis since the three patients only had blood tests every 3 months or when symptoms became severe. These reports do not justify a change of current recommendations regarding influenza vaccination in renal transplant recipients, but they support the continued attention and registration of vaccinations to monitor side effects.

No MeSH data available.


Related in: MedlinePlus