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Enhanced pharmacological activity of vitamin B₁₂ and penicillin as nanoparticles.

Yariv I, Lipovsky A, Gedanken A, Lubart R, Fixler D - Int J Nanomedicine (2015)

Bottom Line: The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively.The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form.Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.

ABSTRACT
Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.

No MeSH data available.


Comparison of FTIR spectra of Penicillin before and after ultrasonic radiation.Notes: FTIR spectrum of bulk Penicillin (solid line) and 5-minute ultrasonicated Penicillin (dashed line). The spectra show no change in the chemical structure of Penicillin upon 5-minute ultrasonic irradiation.Abbreviations: FTIR, Fourier transform infrared spectroscopy; NPs, nanoparticles.
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f3-ijn-10-3593: Comparison of FTIR spectra of Penicillin before and after ultrasonic radiation.Notes: FTIR spectrum of bulk Penicillin (solid line) and 5-minute ultrasonicated Penicillin (dashed line). The spectra show no change in the chemical structure of Penicillin upon 5-minute ultrasonic irradiation.Abbreviations: FTIR, Fourier transform infrared spectroscopy; NPs, nanoparticles.

Mentions: The chemical structure of bulk Penicillin in comparison with nano Penicillin was examined by FTIR spectroscopy. The representative vibrational peaks for Penicillin, presented in Figure 3, were found to be unchanged, and no new peaks were detected. The spectra show no change in the chemical structure of Penicillin upon 5-minute ultrasonic irradiation. The FTIR characterizations of bulk form and nano Penicillin (solid and dashed lines, respectively, in Figure 3) show that the Penicillin molecules did not undergo chemical changes for the duration of the ultrasonic radiation.


Enhanced pharmacological activity of vitamin B₁₂ and penicillin as nanoparticles.

Yariv I, Lipovsky A, Gedanken A, Lubart R, Fixler D - Int J Nanomedicine (2015)

Comparison of FTIR spectra of Penicillin before and after ultrasonic radiation.Notes: FTIR spectrum of bulk Penicillin (solid line) and 5-minute ultrasonicated Penicillin (dashed line). The spectra show no change in the chemical structure of Penicillin upon 5-minute ultrasonic irradiation.Abbreviations: FTIR, Fourier transform infrared spectroscopy; NPs, nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440431&req=5

f3-ijn-10-3593: Comparison of FTIR spectra of Penicillin before and after ultrasonic radiation.Notes: FTIR spectrum of bulk Penicillin (solid line) and 5-minute ultrasonicated Penicillin (dashed line). The spectra show no change in the chemical structure of Penicillin upon 5-minute ultrasonic irradiation.Abbreviations: FTIR, Fourier transform infrared spectroscopy; NPs, nanoparticles.
Mentions: The chemical structure of bulk Penicillin in comparison with nano Penicillin was examined by FTIR spectroscopy. The representative vibrational peaks for Penicillin, presented in Figure 3, were found to be unchanged, and no new peaks were detected. The spectra show no change in the chemical structure of Penicillin upon 5-minute ultrasonic irradiation. The FTIR characterizations of bulk form and nano Penicillin (solid and dashed lines, respectively, in Figure 3) show that the Penicillin molecules did not undergo chemical changes for the duration of the ultrasonic radiation.

Bottom Line: The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively.The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form.Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.

ABSTRACT
Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.

No MeSH data available.