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Enhanced pharmacological activity of vitamin B₁₂ and penicillin as nanoparticles.

Yariv I, Lipovsky A, Gedanken A, Lubart R, Fixler D - Int J Nanomedicine (2015)

Bottom Line: The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively.The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form.Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.

ABSTRACT
Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.

No MeSH data available.


Related in: MedlinePlus

The acoustic cavitation phenomenon that occurs under ultrasonic radiation and the NP creation.Notes: The acoustic cavitation phenomenon happens when a bubble, which was created in the liquid, grows and then collapses. The bubble grows because the solute and/or the solvent vapors diffuse into the volume of the bubble, and it collapses when it gets to its maximum size. In the preparation of nano Penicillin and nano Vitamin B12, the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle that contains many small molecules (a magnification of the nanoparticle is presented in the last phase of the process).Abbreviation: NP, nanoparticle.
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f1-ijn-10-3593: The acoustic cavitation phenomenon that occurs under ultrasonic radiation and the NP creation.Notes: The acoustic cavitation phenomenon happens when a bubble, which was created in the liquid, grows and then collapses. The bubble grows because the solute and/or the solvent vapors diffuse into the volume of the bubble, and it collapses when it gets to its maximum size. In the preparation of nano Penicillin and nano Vitamin B12, the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle that contains many small molecules (a magnification of the nanoparticle is presented in the last phase of the process).Abbreviation: NP, nanoparticle.

Mentions: In recent years, sonochemistry has become a well-known technique for the fabrication of nanomaterials.1–4 Sonochemistry deals with sonic waves, their properties, and their effect on chemical systems. Previous to the sonication process, the bulk solution contains big aggregates of the material molecules, and those aggregates can be broken into molecules by the ultrasonic radiation. When ultrasonic waves (20 KHz–1 MHz) are applied to molecules in solution, they cause a chemical reaction (as shown in Figure 1). This happens due to a phenomenon called acoustic cavitation (the middle part in Figure 1). There are few theories explaining the effect of sonic radiation on the breakdown of chemical bonds. The consensus is that this phenomenon happens when a bubble, which was created in the liquid, grows and then collapses. It grows because the solute and/or the solvent vapors diffuse into the volume of the bubble, and it collapses when it gets to its maximum size. Upon the collapse of the bubble, chemical bonds can be broken/formed due to the development of very high local temperatures (>5,000°C).1 In the preparation of nano Penicillin and nano Vitamin B12, the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle (NP) that contains many small molecules (a magnification of the NP is presented in the last phase of the process described in Figure 1).5


Enhanced pharmacological activity of vitamin B₁₂ and penicillin as nanoparticles.

Yariv I, Lipovsky A, Gedanken A, Lubart R, Fixler D - Int J Nanomedicine (2015)

The acoustic cavitation phenomenon that occurs under ultrasonic radiation and the NP creation.Notes: The acoustic cavitation phenomenon happens when a bubble, which was created in the liquid, grows and then collapses. The bubble grows because the solute and/or the solvent vapors diffuse into the volume of the bubble, and it collapses when it gets to its maximum size. In the preparation of nano Penicillin and nano Vitamin B12, the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle that contains many small molecules (a magnification of the nanoparticle is presented in the last phase of the process).Abbreviation: NP, nanoparticle.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440431&req=5

f1-ijn-10-3593: The acoustic cavitation phenomenon that occurs under ultrasonic radiation and the NP creation.Notes: The acoustic cavitation phenomenon happens when a bubble, which was created in the liquid, grows and then collapses. The bubble grows because the solute and/or the solvent vapors diffuse into the volume of the bubble, and it collapses when it gets to its maximum size. In the preparation of nano Penicillin and nano Vitamin B12, the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle that contains many small molecules (a magnification of the nanoparticle is presented in the last phase of the process).Abbreviation: NP, nanoparticle.
Mentions: In recent years, sonochemistry has become a well-known technique for the fabrication of nanomaterials.1–4 Sonochemistry deals with sonic waves, their properties, and their effect on chemical systems. Previous to the sonication process, the bulk solution contains big aggregates of the material molecules, and those aggregates can be broken into molecules by the ultrasonic radiation. When ultrasonic waves (20 KHz–1 MHz) are applied to molecules in solution, they cause a chemical reaction (as shown in Figure 1). This happens due to a phenomenon called acoustic cavitation (the middle part in Figure 1). There are few theories explaining the effect of sonic radiation on the breakdown of chemical bonds. The consensus is that this phenomenon happens when a bubble, which was created in the liquid, grows and then collapses. It grows because the solute and/or the solvent vapors diffuse into the volume of the bubble, and it collapses when it gets to its maximum size. Upon the collapse of the bubble, chemical bonds can be broken/formed due to the development of very high local temperatures (>5,000°C).1 In the preparation of nano Penicillin and nano Vitamin B12, the material molecules are naturally drawn to the bubble surface, creating a shell of the material molecules around the bubble. During implosion, the molecules shell collapses into the bubble center and thereby creates a nanoparticle (NP) that contains many small molecules (a magnification of the NP is presented in the last phase of the process described in Figure 1).5

Bottom Line: The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively.The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form.Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.

ABSTRACT
Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.

No MeSH data available.


Related in: MedlinePlus