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The usefulness of ozone treatment in spinal pain.

Bocci V, Borrelli E, Zanardi I, Travagli V - Drug Des Devel Ther (2015)

Bottom Line: An in-depth screening of primary sources of information online - via SciFinder Scholar, Google Scholar, and Scopus databases as well as Embase, PubMed, and the Cochrane Database of Systemic Reviews - was performed.In this review, the most significant papers of the last 25 years are presented and their proposals critically evaluated, regardless of the bibliometric impact of the journals.This paper finds favors the full insertion of ozone therapy into pharmaceutical sciences, rather than as either an alternative or an esoteric approach.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Italy.

ABSTRACT

Objective: The aim of this review is to elucidate the biochemical, molecular, immunological, and pharmaceutical mechanisms of action of ozone dissolved in biological fluids. Studies performed during the last two decades allow the drawing of a comprehensive framework for understanding and recommending the integration of ozone therapy for spinal pain.

Methods: An in-depth screening of primary sources of information online - via SciFinder Scholar, Google Scholar, and Scopus databases as well as Embase, PubMed, and the Cochrane Database of Systemic Reviews - was performed. In this review, the most significant papers of the last 25 years are presented and their proposals critically evaluated, regardless of the bibliometric impact of the journals.

Results: The efficacy of standard treatments combined with the unique capacity of ozone therapy to reactivate the innate antioxidant system is the key to correcting the oxidative stress typical of chronic inflammatory diseases. Pain pathways and control systems of algesic signals after ozone administration are described.

Conclusion: This paper finds favors the full insertion of ozone therapy into pharmaceutical sciences, rather than as either an alternative or an esoteric approach.

No MeSH data available.


Related in: MedlinePlus

The inverted U-shaped curve obtained on the basis of the therapeutic effects using an ozone concentration range between 10 and 80 μg/mL of gas per mL of blood, with 100% being the value obtained in basal conditions
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f2-dddt-9-2677: The inverted U-shaped curve obtained on the basis of the therapeutic effects using an ozone concentration range between 10 and 80 μg/mL of gas per mL of blood, with 100% being the value obtained in basal conditions

Mentions: In conclusion, it must be clear that a correct ozonation process either carried out in blood, or intradiscally and intramuscularly, should represent an acute but tolerable oxidative stress giving the hormetic-type response of the interacting biological system (Figure 2). In this paper, the reactions of ozone injected intradiscally or into the paravertebral muscles are discussed in detail. Provided that the ozone dosage is correct, ozone is not deleterious, but, acting as a pro-drug, it is actually capable of eliciting a multitude of useful biological responses and, possibly, reversing a chronic oxidative stress such as those derived from degenerative processes. Indeed the ozone-therapeutic act is interpreted as an atoxic but real “therapeutic shock” able to restore homeostasis.


The usefulness of ozone treatment in spinal pain.

Bocci V, Borrelli E, Zanardi I, Travagli V - Drug Des Devel Ther (2015)

The inverted U-shaped curve obtained on the basis of the therapeutic effects using an ozone concentration range between 10 and 80 μg/mL of gas per mL of blood, with 100% being the value obtained in basal conditions
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4440430&req=5

f2-dddt-9-2677: The inverted U-shaped curve obtained on the basis of the therapeutic effects using an ozone concentration range between 10 and 80 μg/mL of gas per mL of blood, with 100% being the value obtained in basal conditions
Mentions: In conclusion, it must be clear that a correct ozonation process either carried out in blood, or intradiscally and intramuscularly, should represent an acute but tolerable oxidative stress giving the hormetic-type response of the interacting biological system (Figure 2). In this paper, the reactions of ozone injected intradiscally or into the paravertebral muscles are discussed in detail. Provided that the ozone dosage is correct, ozone is not deleterious, but, acting as a pro-drug, it is actually capable of eliciting a multitude of useful biological responses and, possibly, reversing a chronic oxidative stress such as those derived from degenerative processes. Indeed the ozone-therapeutic act is interpreted as an atoxic but real “therapeutic shock” able to restore homeostasis.

Bottom Line: An in-depth screening of primary sources of information online - via SciFinder Scholar, Google Scholar, and Scopus databases as well as Embase, PubMed, and the Cochrane Database of Systemic Reviews - was performed.In this review, the most significant papers of the last 25 years are presented and their proposals critically evaluated, regardless of the bibliometric impact of the journals.This paper finds favors the full insertion of ozone therapy into pharmaceutical sciences, rather than as either an alternative or an esoteric approach.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Italy.

ABSTRACT

Objective: The aim of this review is to elucidate the biochemical, molecular, immunological, and pharmaceutical mechanisms of action of ozone dissolved in biological fluids. Studies performed during the last two decades allow the drawing of a comprehensive framework for understanding and recommending the integration of ozone therapy for spinal pain.

Methods: An in-depth screening of primary sources of information online - via SciFinder Scholar, Google Scholar, and Scopus databases as well as Embase, PubMed, and the Cochrane Database of Systemic Reviews - was performed. In this review, the most significant papers of the last 25 years are presented and their proposals critically evaluated, regardless of the bibliometric impact of the journals.

Results: The efficacy of standard treatments combined with the unique capacity of ozone therapy to reactivate the innate antioxidant system is the key to correcting the oxidative stress typical of chronic inflammatory diseases. Pain pathways and control systems of algesic signals after ozone administration are described.

Conclusion: This paper finds favors the full insertion of ozone therapy into pharmaceutical sciences, rather than as either an alternative or an esoteric approach.

No MeSH data available.


Related in: MedlinePlus