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Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings.

Gerente VM, Schor RR, Chaim KT, Felix Mde M, Ventura DF, Teixeira SH, Lottenberg CL, Amaro E, Paranhos A - PLoS ONE (2015)

Bottom Line: Binocular VF in each quadrant was determined using an integrated method.The response of the visual cortex to binocular stimulation was associated with binocular VF sensitivity.RNFL thickness was associated with the BOLD response of the calcarine and occipital pole ROIs.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Federal University of São Paulo, São Paulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil.

ABSTRACT

Purpose: To evaluate the functional magnetic resonance imaging (fMRI) response to binocular visual stimulation and the association thereof with structural ocular findings and psychophysical test results in patients with glaucoma, and controls.

Methods: Cross-sectional study. Participants underwent a complete ophthalmic examination, including Humphrey 24-2 visual field (VF) testing and optical coherence tomography. Binocular VF in each quadrant was determined using an integrated method. Patients with glaucoma were assigned to three subgroups: initial, asymmetrical and severe glaucoma. Regions of interest (ROIs) were determined anatomically. fMRI (3 T) was performed using a bilaterally presented polar angle stimulus, and the accompanying changes in blood oxygen level-dependent (BOLD) signals were obtained from the occipital poles and calcarine ROIs. We used generalized estimation equation models to compare anatomical and functional data between the groups.

Results: A total of 25 subjects were enrolled, of whom 17 had glaucoma and 8 were controls. Significant associations between quadrant binocular VF sensitivities and fMRI responses were found in the occipital pole ROIs (p = 0.033) and the calcarine ROIs (p = 0.045). In glaucoma severity subgroup analysis, retinal nerve fiber layer (RNFL) thickness was associated with the BOLD response of the calcarine and occipital pole ROIs (p = 0.002 and 0.026, respectively). The initial and asymmetrical glaucoma subgroups had similar binocular VF sensitivities and RNFL thicknesses, but distinct BOLD responses.

Conclusions: The response of the visual cortex to binocular stimulation was associated with binocular VF sensitivity. RNFL thickness was associated with the BOLD response of the calcarine and occipital pole ROIs.

No MeSH data available.


Related in: MedlinePlus

Freesurfer software segmentation of the visual cortex and regions of interest investigated: the occipital pole and the superior and inferior calcarine regions.
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pone.0126362.g001: Freesurfer software segmentation of the visual cortex and regions of interest investigated: the occipital pole and the superior and inferior calcarine regions.

Mentions: All MRI was performed using a 3.0-Tesla instrument (Siemens TIM Trio) with a gradient amplitude of 45 mT/m and a slew ratio of 150 mT/m/s. A reception head coil containing 12 elements was used for image acquisition. Both anatomical and functional scans were obtained. Volumetric T1-weighting images (MPRAGE, TR/TE/TI/FA/VOXEL = 2,500 ms/3.45 ms/1,100 ms/7°/1×1×1 mm3) were automatically processed using the Freesurfer image analysis suite, version 5.1.0, which is well-documented and freely available online (http://surfer.nmr.mgh.harvard.edu/). ROIs were determined anatomically via automatic segmentation using the Aparc.a2009s atlas [26] and used in the fMRI analysis. The ROIs used were the occipital pole and the superior and inferior calcarine regions of each hemisphere (Fig 1).


Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings.

Gerente VM, Schor RR, Chaim KT, Felix Mde M, Ventura DF, Teixeira SH, Lottenberg CL, Amaro E, Paranhos A - PLoS ONE (2015)

Freesurfer software segmentation of the visual cortex and regions of interest investigated: the occipital pole and the superior and inferior calcarine regions.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4430279&req=5

pone.0126362.g001: Freesurfer software segmentation of the visual cortex and regions of interest investigated: the occipital pole and the superior and inferior calcarine regions.
Mentions: All MRI was performed using a 3.0-Tesla instrument (Siemens TIM Trio) with a gradient amplitude of 45 mT/m and a slew ratio of 150 mT/m/s. A reception head coil containing 12 elements was used for image acquisition. Both anatomical and functional scans were obtained. Volumetric T1-weighting images (MPRAGE, TR/TE/TI/FA/VOXEL = 2,500 ms/3.45 ms/1,100 ms/7°/1×1×1 mm3) were automatically processed using the Freesurfer image analysis suite, version 5.1.0, which is well-documented and freely available online (http://surfer.nmr.mgh.harvard.edu/). ROIs were determined anatomically via automatic segmentation using the Aparc.a2009s atlas [26] and used in the fMRI analysis. The ROIs used were the occipital pole and the superior and inferior calcarine regions of each hemisphere (Fig 1).

Bottom Line: Binocular VF in each quadrant was determined using an integrated method.The response of the visual cortex to binocular stimulation was associated with binocular VF sensitivity.RNFL thickness was associated with the BOLD response of the calcarine and occipital pole ROIs.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Federal University of São Paulo, São Paulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil.

ABSTRACT

Purpose: To evaluate the functional magnetic resonance imaging (fMRI) response to binocular visual stimulation and the association thereof with structural ocular findings and psychophysical test results in patients with glaucoma, and controls.

Methods: Cross-sectional study. Participants underwent a complete ophthalmic examination, including Humphrey 24-2 visual field (VF) testing and optical coherence tomography. Binocular VF in each quadrant was determined using an integrated method. Patients with glaucoma were assigned to three subgroups: initial, asymmetrical and severe glaucoma. Regions of interest (ROIs) were determined anatomically. fMRI (3 T) was performed using a bilaterally presented polar angle stimulus, and the accompanying changes in blood oxygen level-dependent (BOLD) signals were obtained from the occipital poles and calcarine ROIs. We used generalized estimation equation models to compare anatomical and functional data between the groups.

Results: A total of 25 subjects were enrolled, of whom 17 had glaucoma and 8 were controls. Significant associations between quadrant binocular VF sensitivities and fMRI responses were found in the occipital pole ROIs (p = 0.033) and the calcarine ROIs (p = 0.045). In glaucoma severity subgroup analysis, retinal nerve fiber layer (RNFL) thickness was associated with the BOLD response of the calcarine and occipital pole ROIs (p = 0.002 and 0.026, respectively). The initial and asymmetrical glaucoma subgroups had similar binocular VF sensitivities and RNFL thicknesses, but distinct BOLD responses.

Conclusions: The response of the visual cortex to binocular stimulation was associated with binocular VF sensitivity. RNFL thickness was associated with the BOLD response of the calcarine and occipital pole ROIs.

No MeSH data available.


Related in: MedlinePlus