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Aberrant function of learning and cognitive control networks underlie inefficient cognitive flexibility in anorexia nervosa: a cross-sectional fMRI study.

Lao-Kaim NP, Fonville L, Giampietro VP, Williams SC, Simmons A, Tchanturia K - PLoS ONE (2015)

Bottom Line: This has previously been attributed to problematic behavioural shifting, characterised by a decrease in fronto-striatal activity.Furthermore, learning was associated with lower blood-oxygenated-level dependent response in the caudate body, as compared to healthy controls.Whilst cognitive flexibility appears to be associated with aberrant functioning of the fronto-parietal control network that mediates between internally and externally directed cognition, fronto-striatal alterations, particularly within the caudate body, were associated with instrumental learning.

View Article: PubMed Central - PubMed

Affiliation: King's College London, Institute of Psychiatry, Department of Psychological Medicine, London, United Kingdom.

ABSTRACT

Objectives: People with Anorexia Nervosa exhibit difficulties flexibly adjusting behaviour in response to environmental changes. This has previously been attributed to problematic behavioural shifting, characterised by a decrease in fronto-striatal activity. Additionally, alterations of instrumental learning, which relies on fronto-striatal networks, may contribute to the observation of inflexible behaviour. The authors sought to investigate the neural correlates of cognitive flexibility and learning in Anorexia Nervosa.

Method: Thirty-two adult females with Anorexia Nervosa and thirty-two age-matched female control participants completed the Wisconsin Card Sorting Task whilst undergoing functional magnetic resonance imaging. Event-related analysis permitted the comparison of cognitive shift trials against those requiring maintenance of rule-sets and allowed assessment of trials representing learning.

Results: Although both groups performed similarly, we found significant interactions in the left middle frontal gyrus, precuneus and superior parietal lobule whereby blood-oxygenated-level dependent response was higher in Anorexia Nervosa patients during shifting but lower when maintaining rule-sets, as compared to healthy controls. During learning, posterior cingulate cortex activity in healthy controls decreased whilst increasing in the Anorexia Nervosa group, whereas the right precuneus exhibited the opposite pattern. Furthermore, learning was associated with lower blood-oxygenated-level dependent response in the caudate body, as compared to healthy controls.

Conclusions: People with Anorexia Nervosa display widespread changes in executive function. Whilst cognitive flexibility appears to be associated with aberrant functioning of the fronto-parietal control network that mediates between internally and externally directed cognition, fronto-striatal alterations, particularly within the caudate body, were associated with instrumental learning. Together, this shows how perseverative tendencies could be a substrate of multiple high-order processes that may contribute to the maintenance of Anorexia Nervosa.

No MeSH data available.


Related in: MedlinePlus

fMRI results of cognitive flexibility comparisons.(A): Axial slices and line graphs showing significant group (Anorexia Nervosa, Healthy Control) x event (Efficient Shift [Eff-Sh], First Correct [F-Corr]) interactions of BOLD response (SSQ value) in the left middle frontal gyrus (BA9, Peak activation Talairach coordinates = -40, 22, 26, cluster size = 14, p = 0.0069), left inferior precuneus (BA7, Peak activation Talairach coordinates = -25, -56, 26, cluster size = 34, p = 0.0029) and left superior parietal lobule extending into the precuneus (BA7, Peak activation Talairach coordinates = -18, -67, 48, cluster size = 17, p = 0.0078). (B): Sagittal slices and bar charts illustrating the BOLD response during SiS-P and Rec-P and corresponding activity during Eff-Sh in the left middle frontal gyrus, left inferior precuneus and left superior parietal lobule. Functional data were thresholded to yield less than 1 false positive cluster per map and overlaid onto a high resolution single subject T1 structural image in Talairach space.
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pone.0124027.g002: fMRI results of cognitive flexibility comparisons.(A): Axial slices and line graphs showing significant group (Anorexia Nervosa, Healthy Control) x event (Efficient Shift [Eff-Sh], First Correct [F-Corr]) interactions of BOLD response (SSQ value) in the left middle frontal gyrus (BA9, Peak activation Talairach coordinates = -40, 22, 26, cluster size = 14, p = 0.0069), left inferior precuneus (BA7, Peak activation Talairach coordinates = -25, -56, 26, cluster size = 34, p = 0.0029) and left superior parietal lobule extending into the precuneus (BA7, Peak activation Talairach coordinates = -18, -67, 48, cluster size = 17, p = 0.0078). (B): Sagittal slices and bar charts illustrating the BOLD response during SiS-P and Rec-P and corresponding activity during Eff-Sh in the left middle frontal gyrus, left inferior precuneus and left superior parietal lobule. Functional data were thresholded to yield less than 1 false positive cluster per map and overlaid onto a high resolution single subject T1 structural image in Talairach space.

Mentions: A group (AN, HC) by event (F-Corr, Eff-Sh) interaction revealed that the AN group exhibited greater activation during Eff-Sh trials but lesser activation during F-Corr trials in the left middle frontal gyrus, left inferior precuneus and left superior parietal lobule, as compared to the HC group (Fig 2A).


Aberrant function of learning and cognitive control networks underlie inefficient cognitive flexibility in anorexia nervosa: a cross-sectional fMRI study.

Lao-Kaim NP, Fonville L, Giampietro VP, Williams SC, Simmons A, Tchanturia K - PLoS ONE (2015)

fMRI results of cognitive flexibility comparisons.(A): Axial slices and line graphs showing significant group (Anorexia Nervosa, Healthy Control) x event (Efficient Shift [Eff-Sh], First Correct [F-Corr]) interactions of BOLD response (SSQ value) in the left middle frontal gyrus (BA9, Peak activation Talairach coordinates = -40, 22, 26, cluster size = 14, p = 0.0069), left inferior precuneus (BA7, Peak activation Talairach coordinates = -25, -56, 26, cluster size = 34, p = 0.0029) and left superior parietal lobule extending into the precuneus (BA7, Peak activation Talairach coordinates = -18, -67, 48, cluster size = 17, p = 0.0078). (B): Sagittal slices and bar charts illustrating the BOLD response during SiS-P and Rec-P and corresponding activity during Eff-Sh in the left middle frontal gyrus, left inferior precuneus and left superior parietal lobule. Functional data were thresholded to yield less than 1 false positive cluster per map and overlaid onto a high resolution single subject T1 structural image in Talairach space.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4430209&req=5

pone.0124027.g002: fMRI results of cognitive flexibility comparisons.(A): Axial slices and line graphs showing significant group (Anorexia Nervosa, Healthy Control) x event (Efficient Shift [Eff-Sh], First Correct [F-Corr]) interactions of BOLD response (SSQ value) in the left middle frontal gyrus (BA9, Peak activation Talairach coordinates = -40, 22, 26, cluster size = 14, p = 0.0069), left inferior precuneus (BA7, Peak activation Talairach coordinates = -25, -56, 26, cluster size = 34, p = 0.0029) and left superior parietal lobule extending into the precuneus (BA7, Peak activation Talairach coordinates = -18, -67, 48, cluster size = 17, p = 0.0078). (B): Sagittal slices and bar charts illustrating the BOLD response during SiS-P and Rec-P and corresponding activity during Eff-Sh in the left middle frontal gyrus, left inferior precuneus and left superior parietal lobule. Functional data were thresholded to yield less than 1 false positive cluster per map and overlaid onto a high resolution single subject T1 structural image in Talairach space.
Mentions: A group (AN, HC) by event (F-Corr, Eff-Sh) interaction revealed that the AN group exhibited greater activation during Eff-Sh trials but lesser activation during F-Corr trials in the left middle frontal gyrus, left inferior precuneus and left superior parietal lobule, as compared to the HC group (Fig 2A).

Bottom Line: This has previously been attributed to problematic behavioural shifting, characterised by a decrease in fronto-striatal activity.Furthermore, learning was associated with lower blood-oxygenated-level dependent response in the caudate body, as compared to healthy controls.Whilst cognitive flexibility appears to be associated with aberrant functioning of the fronto-parietal control network that mediates between internally and externally directed cognition, fronto-striatal alterations, particularly within the caudate body, were associated with instrumental learning.

View Article: PubMed Central - PubMed

Affiliation: King's College London, Institute of Psychiatry, Department of Psychological Medicine, London, United Kingdom.

ABSTRACT

Objectives: People with Anorexia Nervosa exhibit difficulties flexibly adjusting behaviour in response to environmental changes. This has previously been attributed to problematic behavioural shifting, characterised by a decrease in fronto-striatal activity. Additionally, alterations of instrumental learning, which relies on fronto-striatal networks, may contribute to the observation of inflexible behaviour. The authors sought to investigate the neural correlates of cognitive flexibility and learning in Anorexia Nervosa.

Method: Thirty-two adult females with Anorexia Nervosa and thirty-two age-matched female control participants completed the Wisconsin Card Sorting Task whilst undergoing functional magnetic resonance imaging. Event-related analysis permitted the comparison of cognitive shift trials against those requiring maintenance of rule-sets and allowed assessment of trials representing learning.

Results: Although both groups performed similarly, we found significant interactions in the left middle frontal gyrus, precuneus and superior parietal lobule whereby blood-oxygenated-level dependent response was higher in Anorexia Nervosa patients during shifting but lower when maintaining rule-sets, as compared to healthy controls. During learning, posterior cingulate cortex activity in healthy controls decreased whilst increasing in the Anorexia Nervosa group, whereas the right precuneus exhibited the opposite pattern. Furthermore, learning was associated with lower blood-oxygenated-level dependent response in the caudate body, as compared to healthy controls.

Conclusions: People with Anorexia Nervosa display widespread changes in executive function. Whilst cognitive flexibility appears to be associated with aberrant functioning of the fronto-parietal control network that mediates between internally and externally directed cognition, fronto-striatal alterations, particularly within the caudate body, were associated with instrumental learning. Together, this shows how perseverative tendencies could be a substrate of multiple high-order processes that may contribute to the maintenance of Anorexia Nervosa.

No MeSH data available.


Related in: MedlinePlus