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Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.

Schütze C, Wedl M, Baumann B, Pircher M, Hitzenberger CK, Schmidt-Erfurth U - Am. J. Ophthalmol. (2015)

Bottom Line: Reactive accumulation of RPE-related material at the lesion borders increased until month 3 and subsequently decreased.Polarization-sensitive OCT specifically images RPE-related changes in neovascular AMD, contrary to conventional imaging methods.Polarization-sensitive OCT allows for precisely monitoring the sequence of RPE-related morphologic changes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.

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Box-plot analysis of progression in geographic atrophy lesion size during antiangiogenic therapy of neovascular age-related macular degeneration. Although no geographic atrophy (GA) was detectable before treatment, the GA lesion size increased steadily over time. P values refer to changes in relation to previous visit. Gray dots refer to outliers. Mean values of GA area are given for each visit.
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fig7: Box-plot analysis of progression in geographic atrophy lesion size during antiangiogenic therapy of neovascular age-related macular degeneration. Although no geographic atrophy (GA) was detectable before treatment, the GA lesion size increased steadily over time. P values refer to changes in relation to previous visit. Gray dots refer to outliers. Mean values of GA area are given for each visit.

Mentions: No GA lesion was detected by the semiautomated segmentation algorithm in any of the 31 eyes at baseline. However, following 12 months of monthly treatment with anti-VEGF, GA was detected in 17 eyes (55%), and in 19 eyes (61%) at month 24. Of all patients in whom GA was detected, mean GA dimensions were 0.77 mm2 (SD: 0.67, range: 0.12–2.58 mm2) at month 12 and 1.10 mm2 (SD: 1.09, range: 0.14–2.58 mm2) at month 24 (Figure 7), showing continuous expansion throughout a fixed and a flexible regimen. Eyes with CNV that developed GA showed subretinal drusenoid deposits (SDD) in 5 eyes (26%) at month 24. Twenty-six percent of eyes with CNV developing GA showed SDD prior to the visit when GA was first detected. All eyes with SDD and GA revealed multilobular GA.


Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.

Schütze C, Wedl M, Baumann B, Pircher M, Hitzenberger CK, Schmidt-Erfurth U - Am. J. Ophthalmol. (2015)

Box-plot analysis of progression in geographic atrophy lesion size during antiangiogenic therapy of neovascular age-related macular degeneration. Although no geographic atrophy (GA) was detectable before treatment, the GA lesion size increased steadily over time. P values refer to changes in relation to previous visit. Gray dots refer to outliers. Mean values of GA area are given for each visit.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4430174&req=5

fig7: Box-plot analysis of progression in geographic atrophy lesion size during antiangiogenic therapy of neovascular age-related macular degeneration. Although no geographic atrophy (GA) was detectable before treatment, the GA lesion size increased steadily over time. P values refer to changes in relation to previous visit. Gray dots refer to outliers. Mean values of GA area are given for each visit.
Mentions: No GA lesion was detected by the semiautomated segmentation algorithm in any of the 31 eyes at baseline. However, following 12 months of monthly treatment with anti-VEGF, GA was detected in 17 eyes (55%), and in 19 eyes (61%) at month 24. Of all patients in whom GA was detected, mean GA dimensions were 0.77 mm2 (SD: 0.67, range: 0.12–2.58 mm2) at month 12 and 1.10 mm2 (SD: 1.09, range: 0.14–2.58 mm2) at month 24 (Figure 7), showing continuous expansion throughout a fixed and a flexible regimen. Eyes with CNV that developed GA showed subretinal drusenoid deposits (SDD) in 5 eyes (26%) at month 24. Twenty-six percent of eyes with CNV developing GA showed SDD prior to the visit when GA was first detected. All eyes with SDD and GA revealed multilobular GA.

Bottom Line: Reactive accumulation of RPE-related material at the lesion borders increased until month 3 and subsequently decreased.Polarization-sensitive OCT specifically images RPE-related changes in neovascular AMD, contrary to conventional imaging methods.Polarization-sensitive OCT allows for precisely monitoring the sequence of RPE-related morphologic changes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.

Show MeSH
Related in: MedlinePlus