Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.
Bottom Line: Reactive accumulation of RPE-related material at the lesion borders increased until month 3 and subsequently decreased.Polarization-sensitive OCT specifically images RPE-related changes in neovascular AMD, contrary to conventional imaging methods.Polarization-sensitive OCT allows for precisely monitoring the sequence of RPE-related morphologic changes.
Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.Show MeSH
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Mentions: No GA lesion was detected by the semiautomated segmentation algorithm in any of the 31 eyes at baseline. However, following 12 months of monthly treatment with anti-VEGF, GA was detected in 17 eyes (55%), and in 19 eyes (61%) at month 24. Of all patients in whom GA was detected, mean GA dimensions were 0.77 mm2 (SD: 0.67, range: 0.12–2.58 mm2) at month 12 and 1.10 mm2 (SD: 1.09, range: 0.14–2.58 mm2) at month 24 (Figure 7), showing continuous expansion throughout a fixed and a flexible regimen. Eyes with CNV that developed GA showed subretinal drusenoid deposits (SDD) in 5 eyes (26%) at month 24. Twenty-six percent of eyes with CNV developing GA showed SDD prior to the visit when GA was first detected. All eyes with SDD and GA revealed multilobular GA.
Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.