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Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.

Schütze C, Wedl M, Baumann B, Pircher M, Hitzenberger CK, Schmidt-Erfurth U - Am. J. Ophthalmol. (2015)

Bottom Line: Reactive accumulation of RPE-related material at the lesion borders increased until month 3 and subsequently decreased.Polarization-sensitive OCT specifically images RPE-related changes in neovascular AMD, contrary to conventional imaging methods.Polarization-sensitive OCT allows for precisely monitoring the sequence of RPE-related morphologic changes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.

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Related in: MedlinePlus

Accumulations of depolarizing retinal pigment epithelium structures detected by polarization-sensitive optical coherence tomography at baseline (Top) and 6 months (Middle, Bottom) following antiangiogenic therapy initiation of neovascular age-related macular degeneration. In its most advanced form, accumulating retinal pigment epithelium (RPE) at the lesion margins demonstrates a ring-shaped appearance surrounding a classic neovascular lesion. Intensity/RPE overlay (Top left, Middle left); degree of polarization uniformity image (Top right, Middle right); pseudo–scanning laser ophthalmoscopy image (Bottom left); thickness map of depolarizing material (Bottom right); note the increased presence of accumulations of depolarizing material at the RPE level at 6 months compared to baseline (rectangles).
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fig10: Accumulations of depolarizing retinal pigment epithelium structures detected by polarization-sensitive optical coherence tomography at baseline (Top) and 6 months (Middle, Bottom) following antiangiogenic therapy initiation of neovascular age-related macular degeneration. In its most advanced form, accumulating retinal pigment epithelium (RPE) at the lesion margins demonstrates a ring-shaped appearance surrounding a classic neovascular lesion. Intensity/RPE overlay (Top left, Middle left); degree of polarization uniformity image (Top right, Middle right); pseudo–scanning laser ophthalmoscopy image (Bottom left); thickness map of depolarizing material (Bottom right); note the increased presence of accumulations of depolarizing material at the RPE level at 6 months compared to baseline (rectangles).

Mentions: Accumulations of RPE-derived depolarization presented in 7 of 31 eyes (23%) prior to treatment, reaching a maximum at month 3 following anti-VEGF therapy (19 eyes, 61%). Eleven eyes (36%) revealed this pattern at month 12 and 8 eyes (26%) at month 24. A typical ring-shaped appearance of accumulating depolarizing material encapsulating the CNV lesion was observed in 3 eyes with classic CNV (Figure 10). All ring-shaped RPE accumulations progressed toward RPE atrophy with treatment continuation.


Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.

Schütze C, Wedl M, Baumann B, Pircher M, Hitzenberger CK, Schmidt-Erfurth U - Am. J. Ophthalmol. (2015)

Accumulations of depolarizing retinal pigment epithelium structures detected by polarization-sensitive optical coherence tomography at baseline (Top) and 6 months (Middle, Bottom) following antiangiogenic therapy initiation of neovascular age-related macular degeneration. In its most advanced form, accumulating retinal pigment epithelium (RPE) at the lesion margins demonstrates a ring-shaped appearance surrounding a classic neovascular lesion. Intensity/RPE overlay (Top left, Middle left); degree of polarization uniformity image (Top right, Middle right); pseudo–scanning laser ophthalmoscopy image (Bottom left); thickness map of depolarizing material (Bottom right); note the increased presence of accumulations of depolarizing material at the RPE level at 6 months compared to baseline (rectangles).
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4430174&req=5

fig10: Accumulations of depolarizing retinal pigment epithelium structures detected by polarization-sensitive optical coherence tomography at baseline (Top) and 6 months (Middle, Bottom) following antiangiogenic therapy initiation of neovascular age-related macular degeneration. In its most advanced form, accumulating retinal pigment epithelium (RPE) at the lesion margins demonstrates a ring-shaped appearance surrounding a classic neovascular lesion. Intensity/RPE overlay (Top left, Middle left); degree of polarization uniformity image (Top right, Middle right); pseudo–scanning laser ophthalmoscopy image (Bottom left); thickness map of depolarizing material (Bottom right); note the increased presence of accumulations of depolarizing material at the RPE level at 6 months compared to baseline (rectangles).
Mentions: Accumulations of RPE-derived depolarization presented in 7 of 31 eyes (23%) prior to treatment, reaching a maximum at month 3 following anti-VEGF therapy (19 eyes, 61%). Eleven eyes (36%) revealed this pattern at month 12 and 8 eyes (26%) at month 24. A typical ring-shaped appearance of accumulating depolarizing material encapsulating the CNV lesion was observed in 3 eyes with classic CNV (Figure 10). All ring-shaped RPE accumulations progressed toward RPE atrophy with treatment continuation.

Bottom Line: Reactive accumulation of RPE-related material at the lesion borders increased until month 3 and subsequently decreased.Polarization-sensitive OCT specifically images RPE-related changes in neovascular AMD, contrary to conventional imaging methods.Polarization-sensitive OCT allows for precisely monitoring the sequence of RPE-related morphologic changes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.

Show MeSH
Related in: MedlinePlus