Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration.
Bottom Line: Reactive accumulation of RPE-related material at the lesion borders increased until month 3 and subsequently decreased.Polarization-sensitive OCT specifically images RPE-related changes in neovascular AMD, contrary to conventional imaging methods.Polarization-sensitive OCT allows for precisely monitoring the sequence of RPE-related morphologic changes.
Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.Show MeSH
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Mentions: Accumulations of RPE-derived depolarization presented in 7 of 31 eyes (23%) prior to treatment, reaching a maximum at month 3 following anti-VEGF therapy (19 eyes, 61%). Eleven eyes (36%) revealed this pattern at month 12 and 8 eyes (26%) at month 24. A typical ring-shaped appearance of accumulating depolarizing material encapsulating the CNV lesion was observed in 3 eyes with classic CNV (Figure 10). All ring-shaped RPE accumulations progressed toward RPE atrophy with treatment continuation.
Affiliation: Department of Ophthalmology, Medical University of Vienna, Austria, Vienna, Austria.