Limits...
Temporal perception deficits in schizophrenia: integration is the problem, not deployment of attentions.

Su L, Wyble B, Zhou LQ, Wang K, Wang YN, Cheung EF, Bowman H, Chan RC - Sci Rep (2015)

Bottom Line: There was no difference between individuals with/without schizotypal personality disorder in temporal integration.Instead, we used both theoretical and empirical approaches to show that previous findings (using the suppression ratio to correct for the baseline difference) produced a systematic exaggeration of the attention deficits.Instead, we modulated the perceptual difficulty of the task to bring the baseline levels of target detection between the groups into closer alignment.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Psychiatry, University of Cambridge, Cambridge, UK [2] Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
Patients with schizophrenia are known to have impairments in sensory processing. In order to understand the specific temporal perception deficits of schizophrenia, we investigated and determined to what extent impairments in temporal integration can be dissociated from attention deployment using Attentional Blink (AB). Our findings showed that there was no evident deficit in the deployment of attention in patients with schizophrenia. However, patients showed an increased temporal integration deficit within a hundred-millisecond timescale. The degree of such integration dysfunction was correlated with the clinical manifestations of schizophrenia. There was no difference between individuals with/without schizotypal personality disorder in temporal integration. Differently from previous studies using the AB, we did not find a significant impairment in deployment of attention in schizophrenia. Instead, we used both theoretical and empirical approaches to show that previous findings (using the suppression ratio to correct for the baseline difference) produced a systematic exaggeration of the attention deficits. Instead, we modulated the perceptual difficulty of the task to bring the baseline levels of target detection between the groups into closer alignment. We found that the integration dysfunction rather than deployment of attention is clinically relevant, and thus should be an additional focus of research in schizophrenia.

No MeSH data available.


Related in: MedlinePlus

Comparison of SPD with nonSPD: (a) T1 identification accuracy; (b) T2 identification accuracy conditional on correctly reporting T1; (c) Temporal order errors for T1 and T2, i.e. swaps.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4419531&req=5

f4: Comparison of SPD with nonSPD: (a) T1 identification accuracy; (b) T2 identification accuracy conditional on correctly reporting T1; (c) Temporal order errors for T1 and T2, i.e. swaps.

Mentions: As shown in Fig. 4a, there was no significant difference for T1 accuracy at a TOA of 600 ms, t(48) = −0.06, p = 0.95, indicating that baseline perceptual thresholds were equal between groups. From a mixed model ANOVA of T1 accuracy, we found a significant main effect of lag, F(6,288) = 63.49, p < 0.0000001, no significant main effect of group, F(1,48) = 0.059, p = 0.81, and no significant interaction, F(6,288) = 0.58, p = 0.75. For T2 accuracy contingent on T1, a mixed model ANOVA revealed that there was a significant main effect of lag, F(6,288) = 7.84, p = 0.0000001, but no significant effect of group, F(1,48) = 0.003, p = 0.96, and no significant interaction, F(6,288) = 1.13, p = 0.35, with Bayes factor = 0.132 (see Fig. 4b) providing substantial evidence for the over alternative hypothesis. For the probability of order errors, a mixed model ANOVA revealed that there was a significant main effect of lag, F(6,288) = 91.65, p < 0.00000001, no significant main effect of group, F(1,48) = 1.32, p = 0.26, and no significant interaction, F(6,288) = 0.25, p = 0.96 (see Fig. 4c).


Temporal perception deficits in schizophrenia: integration is the problem, not deployment of attentions.

Su L, Wyble B, Zhou LQ, Wang K, Wang YN, Cheung EF, Bowman H, Chan RC - Sci Rep (2015)

Comparison of SPD with nonSPD: (a) T1 identification accuracy; (b) T2 identification accuracy conditional on correctly reporting T1; (c) Temporal order errors for T1 and T2, i.e. swaps.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4419531&req=5

f4: Comparison of SPD with nonSPD: (a) T1 identification accuracy; (b) T2 identification accuracy conditional on correctly reporting T1; (c) Temporal order errors for T1 and T2, i.e. swaps.
Mentions: As shown in Fig. 4a, there was no significant difference for T1 accuracy at a TOA of 600 ms, t(48) = −0.06, p = 0.95, indicating that baseline perceptual thresholds were equal between groups. From a mixed model ANOVA of T1 accuracy, we found a significant main effect of lag, F(6,288) = 63.49, p < 0.0000001, no significant main effect of group, F(1,48) = 0.059, p = 0.81, and no significant interaction, F(6,288) = 0.58, p = 0.75. For T2 accuracy contingent on T1, a mixed model ANOVA revealed that there was a significant main effect of lag, F(6,288) = 7.84, p = 0.0000001, but no significant effect of group, F(1,48) = 0.003, p = 0.96, and no significant interaction, F(6,288) = 1.13, p = 0.35, with Bayes factor = 0.132 (see Fig. 4b) providing substantial evidence for the over alternative hypothesis. For the probability of order errors, a mixed model ANOVA revealed that there was a significant main effect of lag, F(6,288) = 91.65, p < 0.00000001, no significant main effect of group, F(1,48) = 1.32, p = 0.26, and no significant interaction, F(6,288) = 0.25, p = 0.96 (see Fig. 4c).

Bottom Line: There was no difference between individuals with/without schizotypal personality disorder in temporal integration.Instead, we used both theoretical and empirical approaches to show that previous findings (using the suppression ratio to correct for the baseline difference) produced a systematic exaggeration of the attention deficits.Instead, we modulated the perceptual difficulty of the task to bring the baseline levels of target detection between the groups into closer alignment.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Psychiatry, University of Cambridge, Cambridge, UK [2] Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
Patients with schizophrenia are known to have impairments in sensory processing. In order to understand the specific temporal perception deficits of schizophrenia, we investigated and determined to what extent impairments in temporal integration can be dissociated from attention deployment using Attentional Blink (AB). Our findings showed that there was no evident deficit in the deployment of attention in patients with schizophrenia. However, patients showed an increased temporal integration deficit within a hundred-millisecond timescale. The degree of such integration dysfunction was correlated with the clinical manifestations of schizophrenia. There was no difference between individuals with/without schizotypal personality disorder in temporal integration. Differently from previous studies using the AB, we did not find a significant impairment in deployment of attention in schizophrenia. Instead, we used both theoretical and empirical approaches to show that previous findings (using the suppression ratio to correct for the baseline difference) produced a systematic exaggeration of the attention deficits. Instead, we modulated the perceptual difficulty of the task to bring the baseline levels of target detection between the groups into closer alignment. We found that the integration dysfunction rather than deployment of attention is clinically relevant, and thus should be an additional focus of research in schizophrenia.

No MeSH data available.


Related in: MedlinePlus