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A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain.

Lascelles BD, Knazovicky D, Case B, Freire M, Innes JF, Drew AC, Gearing DP - BMC Vet. Res. (2015)

Bottom Line: No side effects were noted.Activity in the NV-01 group increased over the study period compared to placebo (P = 0.063) and the difference between the groups for change in activity over the time period 9am-5pm (8 hours) was significant (P = 0.006).The magnitude of the effect appeared identical to that expected with an NSAID.

View Article: PubMed Central - PubMed

Affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. duncan_lascelles@ncsu.edu.

ABSTRACT

Background: There is a critical need for proven drugs other than non-steroidal anti-inflammatory drugs for treatment of degenerative joint disease (DJD) pain in dogs. Antibodies against nerve growth factor (NGF) are analgesic in rodent models and in humans with DJD. This pilot study aimed to evaluate the efficacy of a novel caninised anti-NGF antibody (NV-01) for the treatment of DJD pain in dogs. In a randomized, parallel group, stratified, double masked, placebo controlled, proof of principle clinical pilot study design, 26 dogs with DJD received NV-01 (200 mcg/kg IV) or placebo on day 0 (D0). In addition to objective accelerometry measures, owners completed clinical metrology instruments (Client-Specific Outcome Measures [CSOM], Canine Brief Pain Inventory [CBPI] and Liverpool Osteoarthritis in Dogs Index [LOAD]) on D0, D14 and D28. CBPI subscales (pain severity [PS] and pain interference [PI]), CSOM and LOAD scores were evaluated within and between groups for change over time. Recognized success/failure criteria were applied and success compared between groups.

Results: CBPI PS and PI scores significantly improved in the NV-01 group (PS: D0-14, P = 0.012 and D0-28, P = 0.019; PI: D0-14, P = 0.012 and D0-28, P = 0.032) but not in the placebo group. CSOM scores showed similar patterns with a significant difference between within-group changes at D14 and D28 (P = 0.038 and P = 0.009, respectively), and significantly more successes at D28 (P = 0.047). LOAD scores significantly improved in the NV-01 group (D0-14, P = 0.004 and D0-28, P = 0.002) but not in the placebo group. There were significant differences between the groups for change in LOAD score at D14 (P = 0.014) and D28 (P = 0.033). No side effects were noted. Activity in the NV-01 group increased over the study period compared to placebo (P = 0.063) and the difference between the groups for change in activity over the time period 9am-5pm (8 hours) was significant (P = 0.006).

Conclusions: These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain. The magnitude of the effect appeared identical to that expected with an NSAID.

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Related in: MedlinePlus

Study participant flow diagram.
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Fig1: Study participant flow diagram.

Mentions: The study was conducted between May and December 2013. Eighty-one enquiries from interested dog owners were received and following a telephone discussion, this resulted in 37 screening appointments (Figure 1). Of these, there were 11 screening failures: 4 for lack of radiographic findings of DJD; 3 for insufficient degree of impairment on the CSOM (Client-Specific Outcome Measures); 2 because of significant stifle instability associated with cruciate ligament rupture; 2 due to concurrent neurologic disease. Twenty-six dogs entered the study. There were no differences between the groups with respect to age, sex distribution, body weight or body condition score (Table 1). There was even distribution of index joints/regions across the two groups (Table 2).Figure 1


A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain.

Lascelles BD, Knazovicky D, Case B, Freire M, Innes JF, Drew AC, Gearing DP - BMC Vet. Res. (2015)

Study participant flow diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4419463&req=5

Fig1: Study participant flow diagram.
Mentions: The study was conducted between May and December 2013. Eighty-one enquiries from interested dog owners were received and following a telephone discussion, this resulted in 37 screening appointments (Figure 1). Of these, there were 11 screening failures: 4 for lack of radiographic findings of DJD; 3 for insufficient degree of impairment on the CSOM (Client-Specific Outcome Measures); 2 because of significant stifle instability associated with cruciate ligament rupture; 2 due to concurrent neurologic disease. Twenty-six dogs entered the study. There were no differences between the groups with respect to age, sex distribution, body weight or body condition score (Table 1). There was even distribution of index joints/regions across the two groups (Table 2).Figure 1

Bottom Line: No side effects were noted.Activity in the NV-01 group increased over the study period compared to placebo (P = 0.063) and the difference between the groups for change in activity over the time period 9am-5pm (8 hours) was significant (P = 0.006).The magnitude of the effect appeared identical to that expected with an NSAID.

View Article: PubMed Central - PubMed

Affiliation: Comparative Pain Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. duncan_lascelles@ncsu.edu.

ABSTRACT

Background: There is a critical need for proven drugs other than non-steroidal anti-inflammatory drugs for treatment of degenerative joint disease (DJD) pain in dogs. Antibodies against nerve growth factor (NGF) are analgesic in rodent models and in humans with DJD. This pilot study aimed to evaluate the efficacy of a novel caninised anti-NGF antibody (NV-01) for the treatment of DJD pain in dogs. In a randomized, parallel group, stratified, double masked, placebo controlled, proof of principle clinical pilot study design, 26 dogs with DJD received NV-01 (200 mcg/kg IV) or placebo on day 0 (D0). In addition to objective accelerometry measures, owners completed clinical metrology instruments (Client-Specific Outcome Measures [CSOM], Canine Brief Pain Inventory [CBPI] and Liverpool Osteoarthritis in Dogs Index [LOAD]) on D0, D14 and D28. CBPI subscales (pain severity [PS] and pain interference [PI]), CSOM and LOAD scores were evaluated within and between groups for change over time. Recognized success/failure criteria were applied and success compared between groups.

Results: CBPI PS and PI scores significantly improved in the NV-01 group (PS: D0-14, P = 0.012 and D0-28, P = 0.019; PI: D0-14, P = 0.012 and D0-28, P = 0.032) but not in the placebo group. CSOM scores showed similar patterns with a significant difference between within-group changes at D14 and D28 (P = 0.038 and P = 0.009, respectively), and significantly more successes at D28 (P = 0.047). LOAD scores significantly improved in the NV-01 group (D0-14, P = 0.004 and D0-28, P = 0.002) but not in the placebo group. There were significant differences between the groups for change in LOAD score at D14 (P = 0.014) and D28 (P = 0.033). No side effects were noted. Activity in the NV-01 group increased over the study period compared to placebo (P = 0.063) and the difference between the groups for change in activity over the time period 9am-5pm (8 hours) was significant (P = 0.006).

Conclusions: These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain. The magnitude of the effect appeared identical to that expected with an NSAID.

Show MeSH
Related in: MedlinePlus