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An unusual case of a well-differentiated neuroendocrine tumour of the ileum with peritoneal carcinomatosis: a case report.

Celotti A, Pulcini G, Schieppati M, Ministrini S, Berruti A, Ronconi M - World J Surg Oncol (2015)

Bottom Line: Neuroendocrine tumours (NETs) are a family of neoplasms that come from neuroendocrine cells and express neural markers, such as synaptophysin or chromogranin A.The current classifications of these tumours are presented by the WHO 2000 classification, based on histological parameters, and the WHO 2010 classification, based on the proliferative index, that divides the NETs into a neuroendocrine tumour of a low grade, neuroendocrine tumour of a intermediate grade and neuroendocrine carcinoma (NEC) of a high grade.We are reporting a very rare case of a G1 low-grade neuroendocrine tumour (NET) of the ileum with a peritoneal carcinomatosis.This case is challenging because the tumour expresses low proliferative index as G1 tumours, but it has an aggressive clinical behaviour such as node metastasis and peritoneal carcinomatosis.The peritoneal carcinomatosis is not actually considered by the current classifications of NETs, so it is difficult to predict the prognosis of this patient.

View Article: PubMed Central - PubMed

Affiliation: Surgical Clinic of Brescia, Piazzale Spedali Civili, 1, Brescia, Italy. ceil85@hotmail.com.

ABSTRACT
Neuroendocrine tumours (NETs) are a family of neoplasms that come from neuroendocrine cells and express neural markers, such as synaptophysin or chromogranin A.The current classifications of these tumours are presented by the WHO 2000 classification, based on histological parameters, and the WHO 2010 classification, based on the proliferative index, that divides the NETs into a neuroendocrine tumour of a low grade, neuroendocrine tumour of a intermediate grade and neuroendocrine carcinoma (NEC) of a high grade.We are reporting a very rare case of a G1 low-grade neuroendocrine tumour (NET) of the ileum with a peritoneal carcinomatosis.This case is challenging because the tumour expresses low proliferative index as G1 tumours, but it has an aggressive clinical behaviour such as node metastasis and peritoneal carcinomatosis.The peritoneal carcinomatosis is not actually considered by the current classifications of NETs, so it is difficult to predict the prognosis of this patient.

No MeSH data available.


Related in: MedlinePlus

Microscopic and molecular aspects of the ileal tumour (a) and the carcinomatosis nodules (b).
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Fig5: Microscopic and molecular aspects of the ileal tumour (a) and the carcinomatosis nodules (b).

Mentions: During the second surgical operation, multiple biopsies of the metastatic nodules and parietal peritoneum were done (left and right pelvic peritoneum, left and right diaphragmatic peritoneum) and a peritoneal cytology was performed. The exploration revealed no other tumours. According to the classification of peritoneal carcinomatosis, the laparoscopic staging showed a peritonial cancer index (PCI) of 4 [12-14]. Peritoneal cytology was negative for malignancy. At the histological examination, carcinomatosis nodules showed the same features of the primary tumour. So the final diagnosis was ileal G1 NET with peritoneal carcinomatosis T4N1M1, stage IV (FiguresĀ 3a, b, 4a, b, and 5a, b).Figure 3


An unusual case of a well-differentiated neuroendocrine tumour of the ileum with peritoneal carcinomatosis: a case report.

Celotti A, Pulcini G, Schieppati M, Ministrini S, Berruti A, Ronconi M - World J Surg Oncol (2015)

Microscopic and molecular aspects of the ileal tumour (a) and the carcinomatosis nodules (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4419448&req=5

Fig5: Microscopic and molecular aspects of the ileal tumour (a) and the carcinomatosis nodules (b).
Mentions: During the second surgical operation, multiple biopsies of the metastatic nodules and parietal peritoneum were done (left and right pelvic peritoneum, left and right diaphragmatic peritoneum) and a peritoneal cytology was performed. The exploration revealed no other tumours. According to the classification of peritoneal carcinomatosis, the laparoscopic staging showed a peritonial cancer index (PCI) of 4 [12-14]. Peritoneal cytology was negative for malignancy. At the histological examination, carcinomatosis nodules showed the same features of the primary tumour. So the final diagnosis was ileal G1 NET with peritoneal carcinomatosis T4N1M1, stage IV (FiguresĀ 3a, b, 4a, b, and 5a, b).Figure 3

Bottom Line: Neuroendocrine tumours (NETs) are a family of neoplasms that come from neuroendocrine cells and express neural markers, such as synaptophysin or chromogranin A.The current classifications of these tumours are presented by the WHO 2000 classification, based on histological parameters, and the WHO 2010 classification, based on the proliferative index, that divides the NETs into a neuroendocrine tumour of a low grade, neuroendocrine tumour of a intermediate grade and neuroendocrine carcinoma (NEC) of a high grade.We are reporting a very rare case of a G1 low-grade neuroendocrine tumour (NET) of the ileum with a peritoneal carcinomatosis.This case is challenging because the tumour expresses low proliferative index as G1 tumours, but it has an aggressive clinical behaviour such as node metastasis and peritoneal carcinomatosis.The peritoneal carcinomatosis is not actually considered by the current classifications of NETs, so it is difficult to predict the prognosis of this patient.

View Article: PubMed Central - PubMed

Affiliation: Surgical Clinic of Brescia, Piazzale Spedali Civili, 1, Brescia, Italy. ceil85@hotmail.com.

ABSTRACT
Neuroendocrine tumours (NETs) are a family of neoplasms that come from neuroendocrine cells and express neural markers, such as synaptophysin or chromogranin A.The current classifications of these tumours are presented by the WHO 2000 classification, based on histological parameters, and the WHO 2010 classification, based on the proliferative index, that divides the NETs into a neuroendocrine tumour of a low grade, neuroendocrine tumour of a intermediate grade and neuroendocrine carcinoma (NEC) of a high grade.We are reporting a very rare case of a G1 low-grade neuroendocrine tumour (NET) of the ileum with a peritoneal carcinomatosis.This case is challenging because the tumour expresses low proliferative index as G1 tumours, but it has an aggressive clinical behaviour such as node metastasis and peritoneal carcinomatosis.The peritoneal carcinomatosis is not actually considered by the current classifications of NETs, so it is difficult to predict the prognosis of this patient.

No MeSH data available.


Related in: MedlinePlus