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Concurrent nonfunctional paraganglioma of the retroperitoneum and urinary bladder: A case report with literature review.

Sherwani P, Anand R, Narula MK, Siddiqui AA, Aggarwal S - Indian J Radiol Imaging (2015 Apr-Jun)

Bottom Line: Tumors arising from the adrenal medulla are known as pheochromocytomas, while others originating from the extra-adrenal site are known as extra-adrenal paragangliomas.Paragangliomas are less functionally active than the pheochromocytomas; they secrete noradrenaline and rarely dopamine, while adrenal pheochromocytomas secrete adrenaline or nor-adrenaline.We report a case of a 45-year-old female with multifocal nonfunctional paragangliomas of the retroperitoneum and urinarybladder which were surgically removed, and the diagnosis was confirmed on histopathology.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

ABSTRACT
Paragangliomas are the neuroendocrine tumors which arise from the chromaffin cell. Tumors arising from the adrenal medulla are known as pheochromocytomas, while others originating from the extra-adrenal site are known as extra-adrenal paragangliomas. Paraganglioma can be multifocal which can arise synchronously or metachronously. Paragangliomas are less functionally active than the pheochromocytomas; they secrete noradrenaline and rarely dopamine, while adrenal pheochromocytomas secrete adrenaline or nor-adrenaline. Nonfunctional multifocal paragangliomas are very rare. We report a case of a 45-year-old female with multifocal nonfunctional paragangliomas of the retroperitoneum and urinarybladder which were surgically removed, and the diagnosis was confirmed on histopathology.

No MeSH data available.


Related in: MedlinePlus

CECT axial sections showing the enhancing mass lesion arising from the anterior wall of urinary bladder (arrow in A). Another similar tiny lesion was seen arising from the posterior wall of bladder (arrow in B)
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Figure 3: CECT axial sections showing the enhancing mass lesion arising from the anterior wall of urinary bladder (arrow in A). Another similar tiny lesion was seen arising from the posterior wall of bladder (arrow in B)

Mentions: For further characterization, biphasic contrast-enhanced computed tomography (CECT) abdomen and pelvis was performed [40slice Philips Brilliance Scanner, New Jersey United States] subsequently. The mass lesion in the retroperitoneum was seen in aortocaval location, causing lateral displacement of inferior vena cava (IVC) [Figure 2B and D]. The mass showed significant enhancement in arterial phase and persistent heterogeneous enhancement in portal venous phase, along with few areas of necrosis. There was anterior displacement and splaying of celiac axis trunk [Figure 2A and B] with anterior displacement of portal vein and pancreas [Figure 2B]. Bilateral adrenal glands were normal [Figure 2C]. The anterior urinary bladder wall lesion also showed intense enhancement [Figure 3A]. There was another similar tiny enhancing lesion seen arising from the posterior wall of bladder [Figure 3B].


Concurrent nonfunctional paraganglioma of the retroperitoneum and urinary bladder: A case report with literature review.

Sherwani P, Anand R, Narula MK, Siddiqui AA, Aggarwal S - Indian J Radiol Imaging (2015 Apr-Jun)

CECT axial sections showing the enhancing mass lesion arising from the anterior wall of urinary bladder (arrow in A). Another similar tiny lesion was seen arising from the posterior wall of bladder (arrow in B)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4419432&req=5

Figure 3: CECT axial sections showing the enhancing mass lesion arising from the anterior wall of urinary bladder (arrow in A). Another similar tiny lesion was seen arising from the posterior wall of bladder (arrow in B)
Mentions: For further characterization, biphasic contrast-enhanced computed tomography (CECT) abdomen and pelvis was performed [40slice Philips Brilliance Scanner, New Jersey United States] subsequently. The mass lesion in the retroperitoneum was seen in aortocaval location, causing lateral displacement of inferior vena cava (IVC) [Figure 2B and D]. The mass showed significant enhancement in arterial phase and persistent heterogeneous enhancement in portal venous phase, along with few areas of necrosis. There was anterior displacement and splaying of celiac axis trunk [Figure 2A and B] with anterior displacement of portal vein and pancreas [Figure 2B]. Bilateral adrenal glands were normal [Figure 2C]. The anterior urinary bladder wall lesion also showed intense enhancement [Figure 3A]. There was another similar tiny enhancing lesion seen arising from the posterior wall of bladder [Figure 3B].

Bottom Line: Tumors arising from the adrenal medulla are known as pheochromocytomas, while others originating from the extra-adrenal site are known as extra-adrenal paragangliomas.Paragangliomas are less functionally active than the pheochromocytomas; they secrete noradrenaline and rarely dopamine, while adrenal pheochromocytomas secrete adrenaline or nor-adrenaline.We report a case of a 45-year-old female with multifocal nonfunctional paragangliomas of the retroperitoneum and urinarybladder which were surgically removed, and the diagnosis was confirmed on histopathology.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

ABSTRACT
Paragangliomas are the neuroendocrine tumors which arise from the chromaffin cell. Tumors arising from the adrenal medulla are known as pheochromocytomas, while others originating from the extra-adrenal site are known as extra-adrenal paragangliomas. Paraganglioma can be multifocal which can arise synchronously or metachronously. Paragangliomas are less functionally active than the pheochromocytomas; they secrete noradrenaline and rarely dopamine, while adrenal pheochromocytomas secrete adrenaline or nor-adrenaline. Nonfunctional multifocal paragangliomas are very rare. We report a case of a 45-year-old female with multifocal nonfunctional paragangliomas of the retroperitoneum and urinarybladder which were surgically removed, and the diagnosis was confirmed on histopathology.

No MeSH data available.


Related in: MedlinePlus