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Imaging in endometrial carcinoma.

Faria SC, Sagebiel T, Balachandran A, Devine C, Lal C, Bhosale PR - Indian J Radiol Imaging (2015 Apr-Jun)

Bottom Line: Several imaging techniques such as transvaginal ultrasonography (TVUS), computed tomography (CT), and magnetic resonance imaging (MRI) have been used as diagnostic tools for preoperative staging of EC.Recently, positron emission tomography (PET), PET/CT, and PET/MRI have also been used in staging these patients.In this article, we review the value of imaging in diagnosis, staging, treatment planning, and detection of recurrent disease in patients with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA.

ABSTRACT
Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States. Prognosis depends on patient age, histological grade, depth of myometrial invasion and/or cervical invasion, and the presence of lymph node metastases. Although EC is staged surgically according to the International Federation of Gynecology and Obstetrics (FIGO) system, preoperative imaging can assist in optimal treatment planning. Several imaging techniques such as transvaginal ultrasonography (TVUS), computed tomography (CT), and magnetic resonance imaging (MRI) have been used as diagnostic tools for preoperative staging of EC. Recently, positron emission tomography (PET), PET/CT, and PET/MRI have also been used in staging these patients. In this article, we review the value of imaging in diagnosis, staging, treatment planning, and detection of recurrent disease in patients with EC.

No MeSH data available.


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A 69-year-old female with history of treated endometrial cancer surgically treated with hysterectomy. (A) Axial T1W and (B) T2W MR images show a complex cystic solid lesion in the pelvic region suggestive of recurrent disease
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Figure 19: A 69-year-old female with history of treated endometrial cancer surgically treated with hysterectomy. (A) Axial T1W and (B) T2W MR images show a complex cystic solid lesion in the pelvic region suggestive of recurrent disease

Mentions: The modalities used for assessing recurrence are CT, MRI, and PET/CT. Recurrence usually occurs at an overall median time of 13 months after primary surgery.[59] The most frequently observed sites of relapse are the vagina, lymph nodes, peritoneum, and lungs [Figures 17–19]. Port site metastases may develop in patients who undergo laparoscopic surgery. The most common site for recurrent EC within the vagina is the vaginal apex. Recurrent tumor appears as a mass with high signal intensity on T2WI and intensely enhances following contrast administration. On FDG-PET, recurrent tumor appears as a focal area of increased uptake. Also, FDG PET/CT plays a role in the detection of recurrent lesions in EC [Figure 17].[60] Kitajima et al. reported a sensitivity, specificity, and accuracy of 90.9%, 93.5%, and 92.2%, respectively, of FDG-PET/CT in the diagnosis of recurrent disease in patients with EC.[51]


Imaging in endometrial carcinoma.

Faria SC, Sagebiel T, Balachandran A, Devine C, Lal C, Bhosale PR - Indian J Radiol Imaging (2015 Apr-Jun)

A 69-year-old female with history of treated endometrial cancer surgically treated with hysterectomy. (A) Axial T1W and (B) T2W MR images show a complex cystic solid lesion in the pelvic region suggestive of recurrent disease
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4419423&req=5

Figure 19: A 69-year-old female with history of treated endometrial cancer surgically treated with hysterectomy. (A) Axial T1W and (B) T2W MR images show a complex cystic solid lesion in the pelvic region suggestive of recurrent disease
Mentions: The modalities used for assessing recurrence are CT, MRI, and PET/CT. Recurrence usually occurs at an overall median time of 13 months after primary surgery.[59] The most frequently observed sites of relapse are the vagina, lymph nodes, peritoneum, and lungs [Figures 17–19]. Port site metastases may develop in patients who undergo laparoscopic surgery. The most common site for recurrent EC within the vagina is the vaginal apex. Recurrent tumor appears as a mass with high signal intensity on T2WI and intensely enhances following contrast administration. On FDG-PET, recurrent tumor appears as a focal area of increased uptake. Also, FDG PET/CT plays a role in the detection of recurrent lesions in EC [Figure 17].[60] Kitajima et al. reported a sensitivity, specificity, and accuracy of 90.9%, 93.5%, and 92.2%, respectively, of FDG-PET/CT in the diagnosis of recurrent disease in patients with EC.[51]

Bottom Line: Several imaging techniques such as transvaginal ultrasonography (TVUS), computed tomography (CT), and magnetic resonance imaging (MRI) have been used as diagnostic tools for preoperative staging of EC.Recently, positron emission tomography (PET), PET/CT, and PET/MRI have also been used in staging these patients.In this article, we review the value of imaging in diagnosis, staging, treatment planning, and detection of recurrent disease in patients with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center, The University of Texas, Houston, Texas, USA.

ABSTRACT
Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States. Prognosis depends on patient age, histological grade, depth of myometrial invasion and/or cervical invasion, and the presence of lymph node metastases. Although EC is staged surgically according to the International Federation of Gynecology and Obstetrics (FIGO) system, preoperative imaging can assist in optimal treatment planning. Several imaging techniques such as transvaginal ultrasonography (TVUS), computed tomography (CT), and magnetic resonance imaging (MRI) have been used as diagnostic tools for preoperative staging of EC. Recently, positron emission tomography (PET), PET/CT, and PET/MRI have also been used in staging these patients. In this article, we review the value of imaging in diagnosis, staging, treatment planning, and detection of recurrent disease in patients with EC.

No MeSH data available.


Related in: MedlinePlus