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Prevalence and characterization of hepatitis B and C virus infections in a needle-sharing population in Northern China.

Xu CJ, Zhang CP, Luo BF, Liu LJ, Wang YZ, Wang XH, He QJ, Zhou SS, Guo WS, Wang JH, Yang RF, Zhang HY, Rao HY, Feng B, Wei L - BMC Public Health (2015)

Bottom Line: The rate of spontaneous HCV RNA clearance was 28.2% (89/316), and was related to the number of injections, time from first injection, and HBsAg positivity.However, HBsAg was related to the anti-HBc signal/cut-off ratio rather than to the above parameters.Trend tests demonstrated that the prevalence of anti-HCV, HCV RNA, and anti-HBc was related to the number of injections (P < 0.001), while HBsAg prevalence was not (P = 0.347).

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, People's Hospital of Kuancheng Manchu Nationality Autonomous County, Hebei, 067600, China. xcj123321@163.com.

ABSTRACT

Background: The epidemiologies of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in specific populations in certain areas of China are poorly understood. A pilot survey of HCV/HBV infections was carried out in villages in Kuancheng County, Heben Province, where injection of sodium benzoate or amphetamines using shared needles has been a common practice. The aims of this study were to analyze the endemicity and characterize HCV/HBV infections in this population.

Methods: Data on demographic characteristics and drug abuse were collected from individuals who signed informed consent forms. Serum HCV antibody (anti-HCV), hepatitis B surface antigen (HBsAg), and hepatitis B core antibody (anti-HBc) were measured in all participants. HCV RNA was measured in samples positive for anti-HCV using real-time polymerase chain reaction.

Results: Among 852 participants from 11 villages, 49.9% had used sodium benzoate or amphetamine at least once, by intravenous injection. The overall prevalence of anti-HCV, HCV RNA, anti-HBc, HBsAg, and HCV/HBV co-infection was 37.1%, 26.6%, 67.7%, 10.7%, and 30.0%, respectively. Two-hundred-twenty-three of 227 (98.2%) participants positive for HCV RNA were aged >40 years. Co-infection was related to sex, age, number of injections, and time from first injection. The rate of spontaneous HCV RNA clearance was 28.2% (89/316), and was related to the number of injections, time from first injection, and HBsAg positivity. However, HBsAg was related to the anti-HBc signal/cut-off ratio rather than to the above parameters. Trend tests demonstrated that the prevalence of anti-HCV, HCV RNA, and anti-HBc was related to the number of injections (P < 0.001), while HBsAg prevalence was not (P = 0.347).

Conclusions: The prevalence of HCV and HBV infection is likely to be high among individuals older than 40 years in areas of needle sharing, and one-time screening for HCV infection should be offered to these populations.

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Percentages of intravenous injections and various positive HCV/HBV markers at different ages.
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Fig1: Percentages of intravenous injections and various positive HCV/HBV markers at different ages.

Mentions: Among the 852 participants from 11 villages, 379 (44.5%) were men. The mean age was 45.16 ± 11.06 years (range: 12–86 years), with 41, 79, 235, 272, 179, and 46 participants aged <30, 30–39, 40–49, 50–59, 60–69, and ≥70 years, respectively. Four-hundred-twenty-five (49.9%) participants had used sodium benzoate or amphetamine at least once, administered by intravenous injection with needle sharing, and 147, 141, and 137 people had injected 1–10, 10–29, and ≥30 times, respectively. The number of injection times was related to the time from first injection to the survey (rs = 0.911, P < 0.001). More men than women had injected intravenously (70.4% vs. 29.6%, χ2 = 229.801, P < 0.001), and people aged ≥40 years accounted for 99.5% of all participants (Figure 1). Compared with participants who had not injected intravenously, those who had injected were older, more likely to be male, and had a higher prevalence of anti-HCV, HCV RNA, and anti-HBc. However, there was no significant difference in the prevalence of HBsAg between the two groups (Table 1).Figure 1


Prevalence and characterization of hepatitis B and C virus infections in a needle-sharing population in Northern China.

Xu CJ, Zhang CP, Luo BF, Liu LJ, Wang YZ, Wang XH, He QJ, Zhou SS, Guo WS, Wang JH, Yang RF, Zhang HY, Rao HY, Feng B, Wei L - BMC Public Health (2015)

Percentages of intravenous injections and various positive HCV/HBV markers at different ages.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4419395&req=5

Fig1: Percentages of intravenous injections and various positive HCV/HBV markers at different ages.
Mentions: Among the 852 participants from 11 villages, 379 (44.5%) were men. The mean age was 45.16 ± 11.06 years (range: 12–86 years), with 41, 79, 235, 272, 179, and 46 participants aged <30, 30–39, 40–49, 50–59, 60–69, and ≥70 years, respectively. Four-hundred-twenty-five (49.9%) participants had used sodium benzoate or amphetamine at least once, administered by intravenous injection with needle sharing, and 147, 141, and 137 people had injected 1–10, 10–29, and ≥30 times, respectively. The number of injection times was related to the time from first injection to the survey (rs = 0.911, P < 0.001). More men than women had injected intravenously (70.4% vs. 29.6%, χ2 = 229.801, P < 0.001), and people aged ≥40 years accounted for 99.5% of all participants (Figure 1). Compared with participants who had not injected intravenously, those who had injected were older, more likely to be male, and had a higher prevalence of anti-HCV, HCV RNA, and anti-HBc. However, there was no significant difference in the prevalence of HBsAg between the two groups (Table 1).Figure 1

Bottom Line: The rate of spontaneous HCV RNA clearance was 28.2% (89/316), and was related to the number of injections, time from first injection, and HBsAg positivity.However, HBsAg was related to the anti-HBc signal/cut-off ratio rather than to the above parameters.Trend tests demonstrated that the prevalence of anti-HCV, HCV RNA, and anti-HBc was related to the number of injections (P < 0.001), while HBsAg prevalence was not (P = 0.347).

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, People's Hospital of Kuancheng Manchu Nationality Autonomous County, Hebei, 067600, China. xcj123321@163.com.

ABSTRACT

Background: The epidemiologies of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in specific populations in certain areas of China are poorly understood. A pilot survey of HCV/HBV infections was carried out in villages in Kuancheng County, Heben Province, where injection of sodium benzoate or amphetamines using shared needles has been a common practice. The aims of this study were to analyze the endemicity and characterize HCV/HBV infections in this population.

Methods: Data on demographic characteristics and drug abuse were collected from individuals who signed informed consent forms. Serum HCV antibody (anti-HCV), hepatitis B surface antigen (HBsAg), and hepatitis B core antibody (anti-HBc) were measured in all participants. HCV RNA was measured in samples positive for anti-HCV using real-time polymerase chain reaction.

Results: Among 852 participants from 11 villages, 49.9% had used sodium benzoate or amphetamine at least once, by intravenous injection. The overall prevalence of anti-HCV, HCV RNA, anti-HBc, HBsAg, and HCV/HBV co-infection was 37.1%, 26.6%, 67.7%, 10.7%, and 30.0%, respectively. Two-hundred-twenty-three of 227 (98.2%) participants positive for HCV RNA were aged >40 years. Co-infection was related to sex, age, number of injections, and time from first injection. The rate of spontaneous HCV RNA clearance was 28.2% (89/316), and was related to the number of injections, time from first injection, and HBsAg positivity. However, HBsAg was related to the anti-HBc signal/cut-off ratio rather than to the above parameters. Trend tests demonstrated that the prevalence of anti-HCV, HCV RNA, and anti-HBc was related to the number of injections (P < 0.001), while HBsAg prevalence was not (P = 0.347).

Conclusions: The prevalence of HCV and HBV infection is likely to be high among individuals older than 40 years in areas of needle sharing, and one-time screening for HCV infection should be offered to these populations.

Show MeSH
Related in: MedlinePlus