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Adrenal suppression following herbal remedy for rheumatoid arthritis.

Premkumar B, Murthy MS, Rajagopal K, Nagaprabu VN, Ponugupati SM - J Pharmacol Pharmacother (2015 Apr-Jun)

Bottom Line: A patient suffering from rheumatoid arthritis who had extreme adrenal suppression as a result of chronic use of herbal medicines presented with complications of adrenal suppression such as muscle weakness.He also had psychiatric disturbances such as confusion and suicidal tendency.Steroids in the herbal medication were found and hence there exists a need for investigation into their safety and efficacy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

ABSTRACT
A patient suffering from rheumatoid arthritis who had extreme adrenal suppression as a result of chronic use of herbal medicines presented with complications of adrenal suppression such as muscle weakness. He also had psychiatric disturbances such as confusion and suicidal tendency. Steroids in the herbal medication were found and hence there exists a need for investigation into their safety and efficacy.

No MeSH data available.


Related in: MedlinePlus

Mass spectrometry of Case 2, who was on herbal medication
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Figure 2: Mass spectrometry of Case 2, who was on herbal medication

Mentions: The herbal samples of the patients were analyzed by mass spectrometry in the Sophisticated Analytical Instrument Facility, Indian Institute of Technology, Chennai. Our aim was to identify whether the steroid substances were present in the herbal preparation. The herbal sample of both cases was screened for the presence of steroidal compounds such as prednisolone (360.44), deflazocort (441.52), hydrocortisone (362.46), dexamethasone (392.46), betamethasone (392.46) and phytosterols such as β-sitosterol (414.70) and stigmasterol (412.69). In the positive ion mode, the sample of case 1 revealed the presence of steroidal compounds by the mass 393.81, which may be dexamethasone or betamethasone [Figure 1]. The positive ion mode of case 2 does not reveal any steroidal compound [Figure 2]. Both the samples show the presence of other mass interferences that may be either phytoconstituents or impurities.


Adrenal suppression following herbal remedy for rheumatoid arthritis.

Premkumar B, Murthy MS, Rajagopal K, Nagaprabu VN, Ponugupati SM - J Pharmacol Pharmacother (2015 Apr-Jun)

Mass spectrometry of Case 2, who was on herbal medication
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4419244&req=5

Figure 2: Mass spectrometry of Case 2, who was on herbal medication
Mentions: The herbal samples of the patients were analyzed by mass spectrometry in the Sophisticated Analytical Instrument Facility, Indian Institute of Technology, Chennai. Our aim was to identify whether the steroid substances were present in the herbal preparation. The herbal sample of both cases was screened for the presence of steroidal compounds such as prednisolone (360.44), deflazocort (441.52), hydrocortisone (362.46), dexamethasone (392.46), betamethasone (392.46) and phytosterols such as β-sitosterol (414.70) and stigmasterol (412.69). In the positive ion mode, the sample of case 1 revealed the presence of steroidal compounds by the mass 393.81, which may be dexamethasone or betamethasone [Figure 1]. The positive ion mode of case 2 does not reveal any steroidal compound [Figure 2]. Both the samples show the presence of other mass interferences that may be either phytoconstituents or impurities.

Bottom Line: A patient suffering from rheumatoid arthritis who had extreme adrenal suppression as a result of chronic use of herbal medicines presented with complications of adrenal suppression such as muscle weakness.He also had psychiatric disturbances such as confusion and suicidal tendency.Steroids in the herbal medication were found and hence there exists a need for investigation into their safety and efficacy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

ABSTRACT
A patient suffering from rheumatoid arthritis who had extreme adrenal suppression as a result of chronic use of herbal medicines presented with complications of adrenal suppression such as muscle weakness. He also had psychiatric disturbances such as confusion and suicidal tendency. Steroids in the herbal medication were found and hence there exists a need for investigation into their safety and efficacy.

No MeSH data available.


Related in: MedlinePlus