Limits...
Adult langerhans cell histiocytosis with hepatic and pulmonary involvement.

Araujo B, Costa F, Lopes J, Castro R - Case Rep Radiol (2015)

Bottom Line: Although common among children, liver involvement is relatively rare in adults and frequently overlooked.Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes.We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.

View Article: PubMed Central - PubMed

Affiliation: Radiology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Although common among children, liver involvement is relatively rare in adults and frequently overlooked. Natural history of liver LCH fits into two stages: an early stage with infiltration by histiocytes and a late stage with sclerosis of the biliary tree. Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes. We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.

No MeSH data available.


Related in: MedlinePlus

Thoracic X-ray: multiple pulmonary nodules are identified, with upper lobe predominance. Note that some nodules show cavitation.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4419232&req=5

fig1: Thoracic X-ray: multiple pulmonary nodules are identified, with upper lobe predominance. Note that some nodules show cavitation.

Mentions: A thoracic X-ray was performed demonstrating multiple nodules with upper predominance, some of which appear cavitated (Figure 1). The thoracic and abdominal enhanced computed tomography (CT) confirmed the presence of multiple infracentimetric centrilobular nodules, some of them cavitated, and cysts (Figures 2 and 3). The surrounding pulmonary parenchyma was normal. These findings predominated in the superior lobes with sparing of the most inferior segments. Hepatomegaly was also present with multiple hypodense hepatic nodules identified, measuring up to 15 mm, some of them confluent. Bile ducts dilatation was not present. No other abdominal abnormalities were found (Figures 4 and 5).


Adult langerhans cell histiocytosis with hepatic and pulmonary involvement.

Araujo B, Costa F, Lopes J, Castro R - Case Rep Radiol (2015)

Thoracic X-ray: multiple pulmonary nodules are identified, with upper lobe predominance. Note that some nodules show cavitation.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4419232&req=5

fig1: Thoracic X-ray: multiple pulmonary nodules are identified, with upper lobe predominance. Note that some nodules show cavitation.
Mentions: A thoracic X-ray was performed demonstrating multiple nodules with upper predominance, some of which appear cavitated (Figure 1). The thoracic and abdominal enhanced computed tomography (CT) confirmed the presence of multiple infracentimetric centrilobular nodules, some of them cavitated, and cysts (Figures 2 and 3). The surrounding pulmonary parenchyma was normal. These findings predominated in the superior lobes with sparing of the most inferior segments. Hepatomegaly was also present with multiple hypodense hepatic nodules identified, measuring up to 15 mm, some of them confluent. Bile ducts dilatation was not present. No other abdominal abnormalities were found (Figures 4 and 5).

Bottom Line: Although common among children, liver involvement is relatively rare in adults and frequently overlooked.Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes.We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.

View Article: PubMed Central - PubMed

Affiliation: Radiology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Although common among children, liver involvement is relatively rare in adults and frequently overlooked. Natural history of liver LCH fits into two stages: an early stage with infiltration by histiocytes and a late stage with sclerosis of the biliary tree. Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes. We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.

No MeSH data available.


Related in: MedlinePlus