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Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Li D, Hao SH, Sun Y, Hu CM, Ma ZH, Wang ZM, Liu J, Liu HB, Ye M, Zhang YF, Yang DS, Shi G - Biomed Res Int (2015)

Bottom Line: Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model.Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417).Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China.

ABSTRACT

Background: This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.

Methods: Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.

Results: We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers.

Conclusion: Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

No MeSH data available.


Related in: MedlinePlus

Sensitivity analysis in present meta-analysis investigates the association between COX-2 polymorphisms and susceptibility to oral cancer ((a) +837 T > C (rs5275) in allele model; (b) +837 T > C (rs5275) in dominant model; (c) −765 G > C (rs20417) in allele model; (d) −765 G > C (rs20417) in dominant model; (e) 1195 A > G (rs689466) in allele model; (f) 1195 A > G (rs689466) in dominant model).
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fig4: Sensitivity analysis in present meta-analysis investigates the association between COX-2 polymorphisms and susceptibility to oral cancer ((a) +837 T > C (rs5275) in allele model; (b) +837 T > C (rs5275) in dominant model; (c) −765 G > C (rs20417) in allele model; (d) −765 G > C (rs20417) in dominant model; (e) 1195 A > G (rs689466) in allele model; (f) 1195 A > G (rs689466) in dominant model).

Mentions: A sensitivity analysis indicated that, except for two selected studies, Lin (2008) related to −765 G > C (rs20417) and Chiang (2008) linked to 1195 A > G (rs689466); the remaining studies had no influence on the estimated pooled RR (Figure 4). The results of metaregression analysis suggested that SNPs, detecting method, year, country, ethnicity, and sample size were not the key factors for heterogeneity (Figure 5, Table 2). Funnel plots demonstrated no evidence of obvious asymmetry and Egger's test illustrated no presence of publication bias (P > 0.05), indicating highly reliable results (Figure 6).


Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Li D, Hao SH, Sun Y, Hu CM, Ma ZH, Wang ZM, Liu J, Liu HB, Ye M, Zhang YF, Yang DS, Shi G - Biomed Res Int (2015)

Sensitivity analysis in present meta-analysis investigates the association between COX-2 polymorphisms and susceptibility to oral cancer ((a) +837 T > C (rs5275) in allele model; (b) +837 T > C (rs5275) in dominant model; (c) −765 G > C (rs20417) in allele model; (d) −765 G > C (rs20417) in dominant model; (e) 1195 A > G (rs689466) in allele model; (f) 1195 A > G (rs689466) in dominant model).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4419230&req=5

fig4: Sensitivity analysis in present meta-analysis investigates the association between COX-2 polymorphisms and susceptibility to oral cancer ((a) +837 T > C (rs5275) in allele model; (b) +837 T > C (rs5275) in dominant model; (c) −765 G > C (rs20417) in allele model; (d) −765 G > C (rs20417) in dominant model; (e) 1195 A > G (rs689466) in allele model; (f) 1195 A > G (rs689466) in dominant model).
Mentions: A sensitivity analysis indicated that, except for two selected studies, Lin (2008) related to −765 G > C (rs20417) and Chiang (2008) linked to 1195 A > G (rs689466); the remaining studies had no influence on the estimated pooled RR (Figure 4). The results of metaregression analysis suggested that SNPs, detecting method, year, country, ethnicity, and sample size were not the key factors for heterogeneity (Figure 5, Table 2). Funnel plots demonstrated no evidence of obvious asymmetry and Egger's test illustrated no presence of publication bias (P > 0.05), indicating highly reliable results (Figure 6).

Bottom Line: Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model.Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417).Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China.

ABSTRACT

Background: This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.

Methods: Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.

Results: We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers.

Conclusion: Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

No MeSH data available.


Related in: MedlinePlus