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Interhemispheric Functional and Structural Disconnection in Alzheimer's Disease: A Combined Resting-State fMRI and DTI Study.

Wang Z, Wang J, Zhang H, Mchugh R, Sun X, Li K, Yang QX - PLoS ONE (2015)

Bottom Line: DTI analysis showed the most significant difference among the three cohorts was the fractional anisotropy in the genu of corpus callosum, which was positively associated with the VMHC of prefrontal and subcortical regions.These results demonstrate that there are specific patterns of interhemispheric functional connectivity changes in the AD and MCI, which can be significantly correlated with the integrity changes in the midline white matter structures.These results suggest that VMHC can be used as a biomarker for the degeneration of the interhemispheric connectivity in AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Neuroimaging studies have demonstrated that patients with Alzheimer's disease presented disconnection syndrome. However, little is known about the alterations of interhemispheric functional interactions and underlying structural connectivity in the AD patients. In this study, we combined resting-state functional MRI and diffusion tensor imaging (DTI) to investigate interhemispheric functional and structural connectivity in 16 AD, 16 mild cognitive impairment (MCI), as well as 16 cognitive normal healthy subjects (CN). The pattern of the resting state interhemispheric functional connectivity was measured with a voxel-mirrored homotopic connectivity (VMHC) method. Decreased VMHC was observed in AD and MCI subjects in anterior brain regions including the prefrontal cortices and subcortical regions with a pattern of AD

No MeSH data available.


Related in: MedlinePlus

Normative VMHC map of the CN group (one-sample t-test, family-wise error corrected, p < 0.001, extent threshold = 10).
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pone.0126310.g001: Normative VMHC map of the CN group (one-sample t-test, family-wise error corrected, p < 0.001, extent threshold = 10).

Mentions: Fig 1 shows the VMHC map of the CN group representing the interhemispheric connectivity in the brain. Each pair of voxels symmetrically located on each hemisphere in the VMHC map represents the correlation coefficient between the time series of the rs-fMRI data from the two voxels. The VMHC map from CN revealed strong interhemispheric connectivities in the brain regions known to be important for cognition, including the anterior and posterior cingulate cortex (ACC and PCC), dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), sensorimotor cortex (SMC), parietal and occipital cortices, hippocampus and various temporal cortices, insula, basal ganglia, and thalamus. This VMHC map from the CN cohort is consistent with those obtained by a previous study [25].


Interhemispheric Functional and Structural Disconnection in Alzheimer's Disease: A Combined Resting-State fMRI and DTI Study.

Wang Z, Wang J, Zhang H, Mchugh R, Sun X, Li K, Yang QX - PLoS ONE (2015)

Normative VMHC map of the CN group (one-sample t-test, family-wise error corrected, p < 0.001, extent threshold = 10).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4418835&req=5

pone.0126310.g001: Normative VMHC map of the CN group (one-sample t-test, family-wise error corrected, p < 0.001, extent threshold = 10).
Mentions: Fig 1 shows the VMHC map of the CN group representing the interhemispheric connectivity in the brain. Each pair of voxels symmetrically located on each hemisphere in the VMHC map represents the correlation coefficient between the time series of the rs-fMRI data from the two voxels. The VMHC map from CN revealed strong interhemispheric connectivities in the brain regions known to be important for cognition, including the anterior and posterior cingulate cortex (ACC and PCC), dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), sensorimotor cortex (SMC), parietal and occipital cortices, hippocampus and various temporal cortices, insula, basal ganglia, and thalamus. This VMHC map from the CN cohort is consistent with those obtained by a previous study [25].

Bottom Line: DTI analysis showed the most significant difference among the three cohorts was the fractional anisotropy in the genu of corpus callosum, which was positively associated with the VMHC of prefrontal and subcortical regions.These results demonstrate that there are specific patterns of interhemispheric functional connectivity changes in the AD and MCI, which can be significantly correlated with the integrity changes in the midline white matter structures.These results suggest that VMHC can be used as a biomarker for the degeneration of the interhemispheric connectivity in AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Neuroimaging studies have demonstrated that patients with Alzheimer's disease presented disconnection syndrome. However, little is known about the alterations of interhemispheric functional interactions and underlying structural connectivity in the AD patients. In this study, we combined resting-state functional MRI and diffusion tensor imaging (DTI) to investigate interhemispheric functional and structural connectivity in 16 AD, 16 mild cognitive impairment (MCI), as well as 16 cognitive normal healthy subjects (CN). The pattern of the resting state interhemispheric functional connectivity was measured with a voxel-mirrored homotopic connectivity (VMHC) method. Decreased VMHC was observed in AD and MCI subjects in anterior brain regions including the prefrontal cortices and subcortical regions with a pattern of AD

No MeSH data available.


Related in: MedlinePlus