Limits...
Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers.

Yan X, Marini J, Mulligan R, Deleault A, Sharma U, Brenner MP, Rutledge GC, Freyman T, Pham QP - PLoS ONE (2015)

Bottom Line: Fibers produced in this study were defect-free (i.e. non-beaded) and core-sheath geometry was visually confirmed under scanning electron microscopy.The versatility of our system was demonstrated by fabrication of (1) fibers encapsulating a drug, (2) bicomponent fibers, (3) hollow fibers, and (4) fibers from a polymer that is not normally electrospinnable.The technological achievements demonstrated in this work significantly advance core-sheath electrospinning towards commercial and manufacturing viability.

View Article: PubMed Central - PubMed

Affiliation: Arsenal Medical, Inc., Watertown, Massachusetts, United States of America.

ABSTRACT
In this work, we report on the development of slit-surface electrospinning--a process that co-localizes two solutions along a slit surface to spontaneously emit multiple core-sheath cone-jets at rates of up to 1 L/h. To the best of our knowledge, this is the first time that production of electrospun core-sheath fibers has been scaled to this magnitude. Fibers produced in this study were defect-free (i.e. non-beaded) and core-sheath geometry was visually confirmed under scanning electron microscopy. The versatility of our system was demonstrated by fabrication of (1) fibers encapsulating a drug, (2) bicomponent fibers, (3) hollow fibers, and (4) fibers from a polymer that is not normally electrospinnable. Additionally, we demonstrate control of the process by modulating parameters such as flow rate, solution viscosity, and fixture design. The technological achievements demonstrated in this work significantly advance core-sheath electrospinning towards commercial and manufacturing viability.

No MeSH data available.


Representative scanning electron images depicting different types of core-sheath fibers fabricated using slit-surface electrospinning.(a) bicomponent (System D) (b) hollow (System E); and (c) unelectrospinnable PDMS core—PLGA sheath (System F).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4418707&req=5

pone.0125407.g003: Representative scanning electron images depicting different types of core-sheath fibers fabricated using slit-surface electrospinning.(a) bicomponent (System D) (b) hollow (System E); and (c) unelectrospinnable PDMS core—PLGA sheath (System F).

Mentions: Physical co-localization of core and sheath solutions by the slit surface increases versatility across materials systems. As a demonstration of this capability, we have also fabricated bicomponent, hollow, and polydimethylsiloxane (not normally electrospinnable) fibers from various different materials systems (see Experimental section for specific details of material systems used). As shown in Fig 3, cross-sections of these fibers distinctively and clearly depict a core-sheath architecture for each fiber type produced. This result is significant, suggesting that a multitude of polymers can be successfully electrospun into core-sheath fibers using our novel slit-surface fixtures (much like coaxial needle electrospinning). Indeed, the current library of materials that have been successfully electrospun so far using our technology include core/sheath polycaprolactone /poly(lactic-co-glycolic) acid, poly(ethylene oxide)/poly(lactic-co-glycolic) acid, poly(lactic-co-glycolic) acid /nylon, polydimethylsiloxane /polyvinylpyrollidone, hydroxypropyl methylcellulose /polyvinlypyrollidone, polyvinylpyrollidone /cellulose acetate, and various polyurethanes. This capability allows for flexibility in material system selection, enabling impact across multiple industries (e.g. textile, medical, energy, diagnostics, etc.).


Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers.

Yan X, Marini J, Mulligan R, Deleault A, Sharma U, Brenner MP, Rutledge GC, Freyman T, Pham QP - PLoS ONE (2015)

Representative scanning electron images depicting different types of core-sheath fibers fabricated using slit-surface electrospinning.(a) bicomponent (System D) (b) hollow (System E); and (c) unelectrospinnable PDMS core—PLGA sheath (System F).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4418707&req=5

pone.0125407.g003: Representative scanning electron images depicting different types of core-sheath fibers fabricated using slit-surface electrospinning.(a) bicomponent (System D) (b) hollow (System E); and (c) unelectrospinnable PDMS core—PLGA sheath (System F).
Mentions: Physical co-localization of core and sheath solutions by the slit surface increases versatility across materials systems. As a demonstration of this capability, we have also fabricated bicomponent, hollow, and polydimethylsiloxane (not normally electrospinnable) fibers from various different materials systems (see Experimental section for specific details of material systems used). As shown in Fig 3, cross-sections of these fibers distinctively and clearly depict a core-sheath architecture for each fiber type produced. This result is significant, suggesting that a multitude of polymers can be successfully electrospun into core-sheath fibers using our novel slit-surface fixtures (much like coaxial needle electrospinning). Indeed, the current library of materials that have been successfully electrospun so far using our technology include core/sheath polycaprolactone /poly(lactic-co-glycolic) acid, poly(ethylene oxide)/poly(lactic-co-glycolic) acid, poly(lactic-co-glycolic) acid /nylon, polydimethylsiloxane /polyvinylpyrollidone, hydroxypropyl methylcellulose /polyvinlypyrollidone, polyvinylpyrollidone /cellulose acetate, and various polyurethanes. This capability allows for flexibility in material system selection, enabling impact across multiple industries (e.g. textile, medical, energy, diagnostics, etc.).

Bottom Line: Fibers produced in this study were defect-free (i.e. non-beaded) and core-sheath geometry was visually confirmed under scanning electron microscopy.The versatility of our system was demonstrated by fabrication of (1) fibers encapsulating a drug, (2) bicomponent fibers, (3) hollow fibers, and (4) fibers from a polymer that is not normally electrospinnable.The technological achievements demonstrated in this work significantly advance core-sheath electrospinning towards commercial and manufacturing viability.

View Article: PubMed Central - PubMed

Affiliation: Arsenal Medical, Inc., Watertown, Massachusetts, United States of America.

ABSTRACT
In this work, we report on the development of slit-surface electrospinning--a process that co-localizes two solutions along a slit surface to spontaneously emit multiple core-sheath cone-jets at rates of up to 1 L/h. To the best of our knowledge, this is the first time that production of electrospun core-sheath fibers has been scaled to this magnitude. Fibers produced in this study were defect-free (i.e. non-beaded) and core-sheath geometry was visually confirmed under scanning electron microscopy. The versatility of our system was demonstrated by fabrication of (1) fibers encapsulating a drug, (2) bicomponent fibers, (3) hollow fibers, and (4) fibers from a polymer that is not normally electrospinnable. Additionally, we demonstrate control of the process by modulating parameters such as flow rate, solution viscosity, and fixture design. The technological achievements demonstrated in this work significantly advance core-sheath electrospinning towards commercial and manufacturing viability.

No MeSH data available.