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Interferon Gamma +874T/A Polymorphism Increases the Risk of Hepatitis Virus-Related Diseases: Evidence from a Meta-Analysis.

Sun Y, Lu Y, Li T, Xie L, Deng Y, Li S, Qin X - PLoS ONE (2015)

Bottom Line: Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to measure the strength of the models.TT+TA: OR=1.350, 95% CI=1.101-1.657, P=0.004, I2%=54.3, and PQ=0.001 for heterogeneity), especially in Asians (OR=1.407, 95% CI=1.035-1.911, P=0.029, I2%=61.9, and PQ=0.005 for heterogeneity) and hepatitis B virus (HBV)-related disease (OR=1.486, 95% CI=1.195-1.849, P=0.000, I2%=40.4, and PQ=0.053 for heterogeneity).Further studies on this topic in different ethnicities, especially genome-wide association studies, should be conducted to strengthen our results.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.

ABSTRACT

Background: Interferon gamma (IFN-γ) is a key regulatory cytokine, which plays an important role in antiviral defense of an infected host. However, the association between the IFN-γ +874T/A gene polymorphism and hepatitis virus-related diseases is heterogeneous.

Methods: Based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement, a comprehensive literature search of eligible studies in Embase, Pubmed, and the Cochrane Library was undertaken through November 2014. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to measure the strength of the models.

Results: Seventeen case-control articles, including 24 studies with 5503 individuals, met the inclusion criteria. The results indicated a statistically significant association between the IFN-γ +874T/A polymorphism and hepatitis virus-related diseases in a recessive gene model (AA vs. TT+TA: OR=1.350, 95% CI=1.101-1.657, P=0.004, I2%=54.3, and PQ=0.001 for heterogeneity), especially in Asians (OR=1.407, 95% CI=1.035-1.911, P=0.029, I2%=61.9, and PQ=0.005 for heterogeneity) and hepatitis B virus (HBV)-related disease (OR=1.486, 95% CI=1.195-1.849, P=0.000, I2%=40.4, and PQ=0.053 for heterogeneity).

Conclusions: The evidence suggests that the IFN-γ +874T/A polymorphism increases the risk of hepatitis virus-related diseases, especially in Asians and HBV-related diseases. Further studies on this topic in different ethnicities, especially genome-wide association studies, should be conducted to strengthen our results.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plot for contrast in a recessive model (AA vs. TT+TA).Each point represents a separate study for the indicated association. Size graph symbol by weights. LogOR natural logarithm of OR. Horizontal line mean effect size.
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pone.0121168.g005: Begg’s funnel plot for contrast in a recessive model (AA vs. TT+TA).Each point represents a separate study for the indicated association. Size graph symbol by weights. LogOR natural logarithm of OR. Horizontal line mean effect size.

Mentions: A Begg’s funnel plot and an Egger’s test were used to investigate the publication bias in the meta-analysis (Fig 5). No significant publication bias was detected with the funnel plot in the overall population in the recessive model. The statistical results of the Egger’s test also provided evidence of funnel plot symmetry (PEgger’s test = 1.840; P = 0.08).


Interferon Gamma +874T/A Polymorphism Increases the Risk of Hepatitis Virus-Related Diseases: Evidence from a Meta-Analysis.

Sun Y, Lu Y, Li T, Xie L, Deng Y, Li S, Qin X - PLoS ONE (2015)

Begg’s funnel plot for contrast in a recessive model (AA vs. TT+TA).Each point represents a separate study for the indicated association. Size graph symbol by weights. LogOR natural logarithm of OR. Horizontal line mean effect size.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4418602&req=5

pone.0121168.g005: Begg’s funnel plot for contrast in a recessive model (AA vs. TT+TA).Each point represents a separate study for the indicated association. Size graph symbol by weights. LogOR natural logarithm of OR. Horizontal line mean effect size.
Mentions: A Begg’s funnel plot and an Egger’s test were used to investigate the publication bias in the meta-analysis (Fig 5). No significant publication bias was detected with the funnel plot in the overall population in the recessive model. The statistical results of the Egger’s test also provided evidence of funnel plot symmetry (PEgger’s test = 1.840; P = 0.08).

Bottom Line: Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to measure the strength of the models.TT+TA: OR=1.350, 95% CI=1.101-1.657, P=0.004, I2%=54.3, and PQ=0.001 for heterogeneity), especially in Asians (OR=1.407, 95% CI=1.035-1.911, P=0.029, I2%=61.9, and PQ=0.005 for heterogeneity) and hepatitis B virus (HBV)-related disease (OR=1.486, 95% CI=1.195-1.849, P=0.000, I2%=40.4, and PQ=0.053 for heterogeneity).Further studies on this topic in different ethnicities, especially genome-wide association studies, should be conducted to strengthen our results.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.

ABSTRACT

Background: Interferon gamma (IFN-γ) is a key regulatory cytokine, which plays an important role in antiviral defense of an infected host. However, the association between the IFN-γ +874T/A gene polymorphism and hepatitis virus-related diseases is heterogeneous.

Methods: Based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement, a comprehensive literature search of eligible studies in Embase, Pubmed, and the Cochrane Library was undertaken through November 2014. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to measure the strength of the models.

Results: Seventeen case-control articles, including 24 studies with 5503 individuals, met the inclusion criteria. The results indicated a statistically significant association between the IFN-γ +874T/A polymorphism and hepatitis virus-related diseases in a recessive gene model (AA vs. TT+TA: OR=1.350, 95% CI=1.101-1.657, P=0.004, I2%=54.3, and PQ=0.001 for heterogeneity), especially in Asians (OR=1.407, 95% CI=1.035-1.911, P=0.029, I2%=61.9, and PQ=0.005 for heterogeneity) and hepatitis B virus (HBV)-related disease (OR=1.486, 95% CI=1.195-1.849, P=0.000, I2%=40.4, and PQ=0.053 for heterogeneity).

Conclusions: The evidence suggests that the IFN-γ +874T/A polymorphism increases the risk of hepatitis virus-related diseases, especially in Asians and HBV-related diseases. Further studies on this topic in different ethnicities, especially genome-wide association studies, should be conducted to strengthen our results.

No MeSH data available.


Related in: MedlinePlus