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Midline or near-midline radioiodine uptake in the oropharyngeal region in patients of differentiated thyroid carcinoma: Differential diagnosis between lingual thyroid and retropharyngeal nodal metastasis, the subtle clues in the scan and their implications for patient management.

Thapa P, Joshi S, Basu S - South Asian J Cancer (2015 Apr-Jun)

View Article: PubMed Central - PubMed

Affiliation: Radiation Medicine Centre (B.A.R.C), Tata Memorial Centre Annexe, Parel, Mumbai, Maharashtra, India.

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Dear Editor, Either lingual thyroid (associated with normal thyroid) or iodine concentrating retropharyngeal lymphadenopathy in patients of differentiated thyroid cancer (DTC) is relatively rare but important clinical entities, that present with remarkably similar finding in postablation radioiodine study... The follow-up radioiodine scan demonstrated focal tracer concentration [Figure 1a] just right to midline in the oral region, which persisted at the same location on repeat scan the next day... The posttreatment study [Figure 3a] demonstrated solitary focus of uptake in oropharyngeal location intense in both anterior and posterior views... The single-photon emission computed tomography (SPECT) images [Figure 3b] further confirmed this... One subtle clue on the planar radioiodine scan is that lingual thyroid is typically midline while retropharyngeal node focus appears slightly lateral to the midline... In the given setting, the lateral views and SPECT helped in confirming its location in posterior oral region... In our case, the follow-up scan [Figure 1] showed a focal tracer concentration just right to the midline and was finally proven to be iodine concentrating the retropharyngeal lymphadenopathy... A plain CT was undertaken to prevent iodide interference from the contrast so that radioiodine therapy could be undertaken if decided for... The current consensus suggests that in case of lingual thyroid in operated DTC, the primary treatment modality being surgery, followed by radioiodine treatment... In the case of retropharyngeal lymphadenopathy, the primary approach should be surgical resection... If not feasible, other treatment modalities may be considered such as radioiodine therapy... Thus, importance of correct diagnosis of midline or near midline uptake in radioiodine study in DTC is important from patient management viewpoint, and the presented subtle clues with correlative anatomical imaging can clinch the correct diagnosis.

No MeSH data available.


Correlative plain computed tomography scan of neck demonstrating a large retropharyngeal lymph node (3.5 cm × 3.0 cm × 2.8 cm) on the right side which in the setting of intense iodine uptake suggested a the diagnosis of metastatic retropharyngeal lymph node
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Figure 2: Correlative plain computed tomography scan of neck demonstrating a large retropharyngeal lymph node (3.5 cm × 3.0 cm × 2.8 cm) on the right side which in the setting of intense iodine uptake suggested a the diagnosis of metastatic retropharyngeal lymph node

Mentions: A plain computed tomography (CT) [Figure 2] of neck undertaken to clarify the exact nature of the uptake showed a right sided large retropharyngeal lymph node (3.5 cm × 3.0 cm × 2.8 cm); in the setting of intense radioiodine uptake, this suggested metastatic retropharyngeal lymph node. Serum thyroglobulin level at this time was 3.2 ng/ml. A surgical opinion was sought, but he declined surgery and was treated with 5.5 GBq of I-131. The posttreatment study [Figure 3a] demonstrated solitary focus of uptake in oropharyngeal location intense in both anterior and posterior views. The single-photon emission computed tomography (SPECT) images [Figure 3b] further confirmed this.


Midline or near-midline radioiodine uptake in the oropharyngeal region in patients of differentiated thyroid carcinoma: Differential diagnosis between lingual thyroid and retropharyngeal nodal metastasis, the subtle clues in the scan and their implications for patient management.

Thapa P, Joshi S, Basu S - South Asian J Cancer (2015 Apr-Jun)

Correlative plain computed tomography scan of neck demonstrating a large retropharyngeal lymph node (3.5 cm × 3.0 cm × 2.8 cm) on the right side which in the setting of intense iodine uptake suggested a the diagnosis of metastatic retropharyngeal lymph node
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4418093&req=5

Figure 2: Correlative plain computed tomography scan of neck demonstrating a large retropharyngeal lymph node (3.5 cm × 3.0 cm × 2.8 cm) on the right side which in the setting of intense iodine uptake suggested a the diagnosis of metastatic retropharyngeal lymph node
Mentions: A plain computed tomography (CT) [Figure 2] of neck undertaken to clarify the exact nature of the uptake showed a right sided large retropharyngeal lymph node (3.5 cm × 3.0 cm × 2.8 cm); in the setting of intense radioiodine uptake, this suggested metastatic retropharyngeal lymph node. Serum thyroglobulin level at this time was 3.2 ng/ml. A surgical opinion was sought, but he declined surgery and was treated with 5.5 GBq of I-131. The posttreatment study [Figure 3a] demonstrated solitary focus of uptake in oropharyngeal location intense in both anterior and posterior views. The single-photon emission computed tomography (SPECT) images [Figure 3b] further confirmed this.

View Article: PubMed Central - PubMed

Affiliation: Radiation Medicine Centre (B.A.R.C), Tata Memorial Centre Annexe, Parel, Mumbai, Maharashtra, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Dear Editor, Either lingual thyroid (associated with normal thyroid) or iodine concentrating retropharyngeal lymphadenopathy in patients of differentiated thyroid cancer (DTC) is relatively rare but important clinical entities, that present with remarkably similar finding in postablation radioiodine study... The follow-up radioiodine scan demonstrated focal tracer concentration [Figure 1a] just right to midline in the oral region, which persisted at the same location on repeat scan the next day... The posttreatment study [Figure 3a] demonstrated solitary focus of uptake in oropharyngeal location intense in both anterior and posterior views... The single-photon emission computed tomography (SPECT) images [Figure 3b] further confirmed this... One subtle clue on the planar radioiodine scan is that lingual thyroid is typically midline while retropharyngeal node focus appears slightly lateral to the midline... In the given setting, the lateral views and SPECT helped in confirming its location in posterior oral region... In our case, the follow-up scan [Figure 1] showed a focal tracer concentration just right to the midline and was finally proven to be iodine concentrating the retropharyngeal lymphadenopathy... A plain CT was undertaken to prevent iodide interference from the contrast so that radioiodine therapy could be undertaken if decided for... The current consensus suggests that in case of lingual thyroid in operated DTC, the primary treatment modality being surgery, followed by radioiodine treatment... In the case of retropharyngeal lymphadenopathy, the primary approach should be surgical resection... If not feasible, other treatment modalities may be considered such as radioiodine therapy... Thus, importance of correct diagnosis of midline or near midline uptake in radioiodine study in DTC is important from patient management viewpoint, and the presented subtle clues with correlative anatomical imaging can clinch the correct diagnosis.

No MeSH data available.