Limits...
Ellagic acid improved arrhythmias induced by CaCL2 in the rat stress model.

Dianat M, Amini N, Badavi M, Farbood Y - Avicenna J Phytomed (2015 Mar-Apr)

Bottom Line: Results were analyzed by using one-way ANOVA and Fisher`s exact test. p<0.05 was considered as significant level.The results showed a positive inotropic effect and negative chronotropic effect for the EA group in comparison with the control group.By decreasing the incidence rates of premature beats, fibrillation and ventricular tachycardia in groups which received EA, ellagic acid probably acted as an anti-arrhythmic agent which showed to have aprotective functionin heart.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center and Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

ABSTRACT

Objective: In ventricular arrhythmias, due to their free radical scavenging action, antioxidant agents are usually used in the treatment of cardiovascular disease. Since stress is considered as risk factor for increased mortality by causing malignant arrhythmias, the study was designed to evaluate the cardioprotective effects of ellagic acid (EA) on CaCl2-induced arrhythmias in rat stress model.

Materials and methods: Male Sprague-Dawley rats (200-250 g) were divided into four groups: Group I: Control rats (2 ml of saline by gavage), Group II: Rats treated with EA (15 mg/kg, gavage), Group III: stress group, Group IV: received EA plus stress. Stress was applied in a restrainer box (6 hour/day, 21 days). After induction of anesthesia, lead II electrocardiogram was recorded for calculating heart rate and QRS complex. The arrhythmia was produced by injection of CaCl2 solution (140 mg/kg, iv) and incidences of Ventricular fibrillation, Ventricular premature beats and Ventricular tachycardia were recorded. Results were analyzed by using one-way ANOVA and Fisher`s exact test. p<0.05 was considered as significant level.

Results: The results showed a positive inotropic effect and negative chronotropic effect for the EA group in comparison with the control group. Incidence rates (%) of premature beats, ventricular fibrillation and ventricular tachycardia in stress group and all the arrhythmia parameters decreased in groups which received EA.

Conclusions: By decreasing the incidence rates of premature beats, fibrillation and ventricular tachycardia in groups which received EA, ellagic acid probably acted as an anti-arrhythmic agent which showed to have aprotective functionin heart.

No MeSH data available.


Related in: MedlinePlus

Evaluation of premature ventricular beats after Chemical arrhythmias inducing by intravenous CaCl2 injection (140 mg/kg) in different rats groups [(control), (Ellagic Acid 15 mg/kg), (Stress), (Ellagic Acid + Stress)]. *p<0.05, ***p<0.001. Significant differences with control group (n=8, Fisher`s exact test).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4418061&req=5

Figure 5: Evaluation of premature ventricular beats after Chemical arrhythmias inducing by intravenous CaCl2 injection (140 mg/kg) in different rats groups [(control), (Ellagic Acid 15 mg/kg), (Stress), (Ellagic Acid + Stress)]. *p<0.05, ***p<0.001. Significant differences with control group (n=8, Fisher`s exact test).

Mentions: Rats receiving EA (15 mg/kg), showed a significant decrease in percentages of incidence of ventricular tachycardia (p<0.05) (Fig. 3), Ventricular fibrillation (p<0.01) (Fig. 4) and Ventricular premature beats (p<0.001) (Fig. 5) Rats exposed to chronic stress for 21 days (6 hours per day), showed a significant increase in percentages of incidence of ventricular tachycardia (p<0.01), Ventricular fibrillation (p<0.01) and Ventricular premature beats (p<0.01). Finally, rats exposed to chronic stress and receiving EA (15 mg/kg), showed a significant decrease in percentage of incidence of ventricular tachycardia (p<0.05), Ventricular fibrillation (p<0.05) and Ventricular premature beats (p<0.05) (Fig. 3-5).


Ellagic acid improved arrhythmias induced by CaCL2 in the rat stress model.

Dianat M, Amini N, Badavi M, Farbood Y - Avicenna J Phytomed (2015 Mar-Apr)

Evaluation of premature ventricular beats after Chemical arrhythmias inducing by intravenous CaCl2 injection (140 mg/kg) in different rats groups [(control), (Ellagic Acid 15 mg/kg), (Stress), (Ellagic Acid + Stress)]. *p<0.05, ***p<0.001. Significant differences with control group (n=8, Fisher`s exact test).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4418061&req=5

Figure 5: Evaluation of premature ventricular beats after Chemical arrhythmias inducing by intravenous CaCl2 injection (140 mg/kg) in different rats groups [(control), (Ellagic Acid 15 mg/kg), (Stress), (Ellagic Acid + Stress)]. *p<0.05, ***p<0.001. Significant differences with control group (n=8, Fisher`s exact test).
Mentions: Rats receiving EA (15 mg/kg), showed a significant decrease in percentages of incidence of ventricular tachycardia (p<0.05) (Fig. 3), Ventricular fibrillation (p<0.01) (Fig. 4) and Ventricular premature beats (p<0.001) (Fig. 5) Rats exposed to chronic stress for 21 days (6 hours per day), showed a significant increase in percentages of incidence of ventricular tachycardia (p<0.01), Ventricular fibrillation (p<0.01) and Ventricular premature beats (p<0.01). Finally, rats exposed to chronic stress and receiving EA (15 mg/kg), showed a significant decrease in percentage of incidence of ventricular tachycardia (p<0.05), Ventricular fibrillation (p<0.05) and Ventricular premature beats (p<0.05) (Fig. 3-5).

Bottom Line: Results were analyzed by using one-way ANOVA and Fisher`s exact test. p<0.05 was considered as significant level.The results showed a positive inotropic effect and negative chronotropic effect for the EA group in comparison with the control group.By decreasing the incidence rates of premature beats, fibrillation and ventricular tachycardia in groups which received EA, ellagic acid probably acted as an anti-arrhythmic agent which showed to have aprotective functionin heart.

View Article: PubMed Central - PubMed

Affiliation: Physiology Research Center and Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

ABSTRACT

Objective: In ventricular arrhythmias, due to their free radical scavenging action, antioxidant agents are usually used in the treatment of cardiovascular disease. Since stress is considered as risk factor for increased mortality by causing malignant arrhythmias, the study was designed to evaluate the cardioprotective effects of ellagic acid (EA) on CaCl2-induced arrhythmias in rat stress model.

Materials and methods: Male Sprague-Dawley rats (200-250 g) were divided into four groups: Group I: Control rats (2 ml of saline by gavage), Group II: Rats treated with EA (15 mg/kg, gavage), Group III: stress group, Group IV: received EA plus stress. Stress was applied in a restrainer box (6 hour/day, 21 days). After induction of anesthesia, lead II electrocardiogram was recorded for calculating heart rate and QRS complex. The arrhythmia was produced by injection of CaCl2 solution (140 mg/kg, iv) and incidences of Ventricular fibrillation, Ventricular premature beats and Ventricular tachycardia were recorded. Results were analyzed by using one-way ANOVA and Fisher`s exact test. p<0.05 was considered as significant level.

Results: The results showed a positive inotropic effect and negative chronotropic effect for the EA group in comparison with the control group. Incidence rates (%) of premature beats, ventricular fibrillation and ventricular tachycardia in stress group and all the arrhythmia parameters decreased in groups which received EA.

Conclusions: By decreasing the incidence rates of premature beats, fibrillation and ventricular tachycardia in groups which received EA, ellagic acid probably acted as an anti-arrhythmic agent which showed to have aprotective functionin heart.

No MeSH data available.


Related in: MedlinePlus