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Modulation of immune response by organophosphorus pesticides: fishes as a potential model in immunotoxicology.

Díaz-Resendiz KJ, Toledo-Ibarra GA, Girón-Pérez MI - J Immunol Res (2015)

Bottom Line: Nevertheless, some of these may cause an immunotoxic effect.In this paper, the effect of organophosphorus pesticides (frequent substances spilled in aquatic ecosystems) on the immune system of fishes and in immunotoxicology is reviewed.Furthermore, some cellular and molecular mechanisms that might be involved in immunoregulation mechanisms of organophosphorus pesticides are discussed.

View Article: PubMed Central - PubMed

Affiliation: Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Ciudad de la Cultura s/n, 63000 Tepic, NAY, Mexico.

ABSTRACT
Immune response is modulated by different substances that are present in the environment. Nevertheless, some of these may cause an immunotoxic effect. In this paper, the effect of organophosphorus pesticides (frequent substances spilled in aquatic ecosystems) on the immune system of fishes and in immunotoxicology is reviewed. Furthermore, some cellular and molecular mechanisms that might be involved in immunoregulation mechanisms of organophosphorus pesticides are discussed.

No MeSH data available.


Related in: MedlinePlus

Mechanisms of immunotoxicity of OPs. The potential immunotoxicity mechanisms could involve effect directly on immune cells or through neuroimmune communication disturbance. AcCoA: acetyl-coenzyme A; ACh: acetylcholine; AChE: acetylcholinesterase; ChAT: acetylcholine transferase; CYP450: Cytochrome P450; DAPS: dialkylphosphates; mAChR: muscarinic acetylcholine receptor; nAChR: nicotinic acetylcholine receptor; OPs: organophosphorus pesticides; oxon: oxidized metabolite of OPs; PON: paraoxonase.
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Related In: Results  -  Collection


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fig1: Mechanisms of immunotoxicity of OPs. The potential immunotoxicity mechanisms could involve effect directly on immune cells or through neuroimmune communication disturbance. AcCoA: acetyl-coenzyme A; ACh: acetylcholine; AChE: acetylcholinesterase; ChAT: acetylcholine transferase; CYP450: Cytochrome P450; DAPS: dialkylphosphates; mAChR: muscarinic acetylcholine receptor; nAChR: nicotinic acetylcholine receptor; OPs: organophosphorus pesticides; oxon: oxidized metabolite of OPs; PON: paraoxonase.

Mentions: The effects mentioned above show that OPs alter the function of certain elements of the immune system, even though the mechanisms of immunotoxicity of the OPs are not clear. Such mechanism of OPs is not direct but it works through indirect mechanisms, topics that will be discussed in this section, based on evidence shown in different animal models (Figure 1).


Modulation of immune response by organophosphorus pesticides: fishes as a potential model in immunotoxicology.

Díaz-Resendiz KJ, Toledo-Ibarra GA, Girón-Pérez MI - J Immunol Res (2015)

Mechanisms of immunotoxicity of OPs. The potential immunotoxicity mechanisms could involve effect directly on immune cells or through neuroimmune communication disturbance. AcCoA: acetyl-coenzyme A; ACh: acetylcholine; AChE: acetylcholinesterase; ChAT: acetylcholine transferase; CYP450: Cytochrome P450; DAPS: dialkylphosphates; mAChR: muscarinic acetylcholine receptor; nAChR: nicotinic acetylcholine receptor; OPs: organophosphorus pesticides; oxon: oxidized metabolite of OPs; PON: paraoxonase.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4417994&req=5

fig1: Mechanisms of immunotoxicity of OPs. The potential immunotoxicity mechanisms could involve effect directly on immune cells or through neuroimmune communication disturbance. AcCoA: acetyl-coenzyme A; ACh: acetylcholine; AChE: acetylcholinesterase; ChAT: acetylcholine transferase; CYP450: Cytochrome P450; DAPS: dialkylphosphates; mAChR: muscarinic acetylcholine receptor; nAChR: nicotinic acetylcholine receptor; OPs: organophosphorus pesticides; oxon: oxidized metabolite of OPs; PON: paraoxonase.
Mentions: The effects mentioned above show that OPs alter the function of certain elements of the immune system, even though the mechanisms of immunotoxicity of the OPs are not clear. Such mechanism of OPs is not direct but it works through indirect mechanisms, topics that will be discussed in this section, based on evidence shown in different animal models (Figure 1).

Bottom Line: Nevertheless, some of these may cause an immunotoxic effect.In this paper, the effect of organophosphorus pesticides (frequent substances spilled in aquatic ecosystems) on the immune system of fishes and in immunotoxicology is reviewed.Furthermore, some cellular and molecular mechanisms that might be involved in immunoregulation mechanisms of organophosphorus pesticides are discussed.

View Article: PubMed Central - PubMed

Affiliation: Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Ciudad de la Cultura s/n, 63000 Tepic, NAY, Mexico.

ABSTRACT
Immune response is modulated by different substances that are present in the environment. Nevertheless, some of these may cause an immunotoxic effect. In this paper, the effect of organophosphorus pesticides (frequent substances spilled in aquatic ecosystems) on the immune system of fishes and in immunotoxicology is reviewed. Furthermore, some cellular and molecular mechanisms that might be involved in immunoregulation mechanisms of organophosphorus pesticides are discussed.

No MeSH data available.


Related in: MedlinePlus