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SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma.

Chen D, Li Y, Wang L, Jiao K - Int J Breast Cancer (2015)

Bottom Line: We found 6-gene expression profile that can be used as such predictors.Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression.The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA ; Comprehensive Cancer Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

ABSTRACT
Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients' survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

No MeSH data available.


Related in: MedlinePlus

Activation of SEMA6D and transcription. The gene-gene interaction network was built based on direct interactions by using Ingenuity Pathway Analysis (IPA) suite. Color indicates increased (in red) expression when SEMA6D-high samples were compared with SEMA6D-low samples. The number indicated the fold changes of this comparison.
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fig4: Activation of SEMA6D and transcription. The gene-gene interaction network was built based on direct interactions by using Ingenuity Pathway Analysis (IPA) suite. Color indicates increased (in red) expression when SEMA6D-high samples were compared with SEMA6D-low samples. The number indicated the fold changes of this comparison.

Mentions: The GO-molecular functions also reveal that receptor activity, sequence-specific DNA binding, and voltage-gated sodium channel activities are among top affected molecular functions when SEMA6D level is high (Table 2). These results suggest that SEMA6D may initiate member receptors activation as a ligand. The gene-gene interactions among those genes that directly or indirectly interact with SEMA6D partially confirmed this hypothesis. As shown in Figure 4, elevated PLXNA4 may lead to an increase of SEMA6D expression and trigger transcriptions by the general transcription factors FOS and FOXO1. This may lead to a cascade of activations of membrane receptors including G-protein coupled receptors (Table 2).


SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma.

Chen D, Li Y, Wang L, Jiao K - Int J Breast Cancer (2015)

Activation of SEMA6D and transcription. The gene-gene interaction network was built based on direct interactions by using Ingenuity Pathway Analysis (IPA) suite. Color indicates increased (in red) expression when SEMA6D-high samples were compared with SEMA6D-low samples. The number indicated the fold changes of this comparison.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4417987&req=5

fig4: Activation of SEMA6D and transcription. The gene-gene interaction network was built based on direct interactions by using Ingenuity Pathway Analysis (IPA) suite. Color indicates increased (in red) expression when SEMA6D-high samples were compared with SEMA6D-low samples. The number indicated the fold changes of this comparison.
Mentions: The GO-molecular functions also reveal that receptor activity, sequence-specific DNA binding, and voltage-gated sodium channel activities are among top affected molecular functions when SEMA6D level is high (Table 2). These results suggest that SEMA6D may initiate member receptors activation as a ligand. The gene-gene interactions among those genes that directly or indirectly interact with SEMA6D partially confirmed this hypothesis. As shown in Figure 4, elevated PLXNA4 may lead to an increase of SEMA6D expression and trigger transcriptions by the general transcription factors FOS and FOXO1. This may lead to a cascade of activations of membrane receptors including G-protein coupled receptors (Table 2).

Bottom Line: We found 6-gene expression profile that can be used as such predictors.Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression.The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA ; Comprehensive Cancer Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

ABSTRACT
Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients' survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

No MeSH data available.


Related in: MedlinePlus