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Comparative investigation of the efficacy of three different adsorbents against OTA-induced toxicity in broiler chickens.

Nedeljković-Trailović J, Trailović S, Resanović R, Milićević D, Jovanovic M, Vasiljevic M - Toxins (Basel) (2015)

Bottom Line: The presence of inorganic, organic and mixed adsorbents in contaminated feed only partially reduced the negative effects of OTA on the broiler performances.The presence of adsorbents partially alleviated the reduction in feed consumption (22.68%, 12.91% and 10.59%), and a similar effect was observed with feed conversion.After the withdrawal of the toxin and adsorbents from the feed (21-42 days), all previously observed disturbances in broilers were reduced, but more remarkably in broilers fed with adsorbents.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia. tjelena@vet.bg.ac.rs.

ABSTRACT
The aim of our study was to determine the efficacy of three different adsorbents, inorganic (modified zeolite), organic (esterified glucomannans) and mixed (inorganic and organic components, with the addition of enzymes), in protecting broilers from the toxic effects of ochratoxin A in feed. Broilers were fed diets containing 2 mg/kg of ochratoxin A (OTA) and supplemented with adsorbents at the recommended concentration of 2 g/kg for 21 days. The presence of OTA led to a notable reduction in body weight, lower weight gain, increased feed conversion and induced histopathological changes in the liver and kidneys. The presence of inorganic, organic and mixed adsorbents in contaminated feed only partially reduced the negative effects of OTA on the broiler performances. Broilers that were fed with adsorbent-supplemented feed reached higher body weight (17.96%, 19.09% and 13.59%), compared to the group that received only OTA. The presence of adsorbents partially alleviated the reduction in feed consumption (22.68%, 12.91% and 10.59%), and a similar effect was observed with feed conversion. The applied adsorbents have also reduced the intensity of histopathological changes caused by OTA; however, they were not able to prevent their onset. After the withdrawal of the toxin and adsorbents from the feed (21-42 days), all previously observed disturbances in broilers were reduced, but more remarkably in broilers fed with adsorbents.

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(a) Edema of the renal proximal tubule cells with partial tubule lumen stenosis, dystrophic changes with the appearance of apoptotic bodies, E-II group; (b) Proliferation of mesangial cells and capillary endothelial cells in the glomeruli, E-II group; (c) Regenerative changes in the tubulocytes, E-I group after the withdrawal period; (d) Regenerative changes in the tubulocytes and sclerotic changes in the glomeruli, E-I group after the withdrawal period.
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toxins-07-01174-f002: (a) Edema of the renal proximal tubule cells with partial tubule lumen stenosis, dystrophic changes with the appearance of apoptotic bodies, E-II group; (b) Proliferation of mesangial cells and capillary endothelial cells in the glomeruli, E-II group; (c) Regenerative changes in the tubulocytes, E-I group after the withdrawal period; (d) Regenerative changes in the tubulocytes and sclerotic changes in the glomeruli, E-I group after the withdrawal period.

Mentions: Pathohistological examination of broilers from Group E-II, which were fed a mixture contaminated with 2 mg/kg of OTA and 0.2% of inorganic adsorbent, revealed that changes were of a lower intensity compared to the group that received only OTA. Changes were manifested in the form of focal fat accumulation within hepatocytes. In the kidneys of broilers from Group E-II, changes in the form of edema of the renal proximal tubule cells were noted, as well as vacuolation with partial tubule lumen stenosis, but without any signs of necrosis (Figure 2a). Proliferation of mesangial cells and capillary endothelial cell edema was noted in some of the birds from this experimental group, as well as hyperemia, which consequently led to an increase in glomerular volume (Figure 2b).


Comparative investigation of the efficacy of three different adsorbents against OTA-induced toxicity in broiler chickens.

Nedeljković-Trailović J, Trailović S, Resanović R, Milićević D, Jovanovic M, Vasiljevic M - Toxins (Basel) (2015)

(a) Edema of the renal proximal tubule cells with partial tubule lumen stenosis, dystrophic changes with the appearance of apoptotic bodies, E-II group; (b) Proliferation of mesangial cells and capillary endothelial cells in the glomeruli, E-II group; (c) Regenerative changes in the tubulocytes, E-I group after the withdrawal period; (d) Regenerative changes in the tubulocytes and sclerotic changes in the glomeruli, E-I group after the withdrawal period.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4417962&req=5

toxins-07-01174-f002: (a) Edema of the renal proximal tubule cells with partial tubule lumen stenosis, dystrophic changes with the appearance of apoptotic bodies, E-II group; (b) Proliferation of mesangial cells and capillary endothelial cells in the glomeruli, E-II group; (c) Regenerative changes in the tubulocytes, E-I group after the withdrawal period; (d) Regenerative changes in the tubulocytes and sclerotic changes in the glomeruli, E-I group after the withdrawal period.
Mentions: Pathohistological examination of broilers from Group E-II, which were fed a mixture contaminated with 2 mg/kg of OTA and 0.2% of inorganic adsorbent, revealed that changes were of a lower intensity compared to the group that received only OTA. Changes were manifested in the form of focal fat accumulation within hepatocytes. In the kidneys of broilers from Group E-II, changes in the form of edema of the renal proximal tubule cells were noted, as well as vacuolation with partial tubule lumen stenosis, but without any signs of necrosis (Figure 2a). Proliferation of mesangial cells and capillary endothelial cell edema was noted in some of the birds from this experimental group, as well as hyperemia, which consequently led to an increase in glomerular volume (Figure 2b).

Bottom Line: The presence of inorganic, organic and mixed adsorbents in contaminated feed only partially reduced the negative effects of OTA on the broiler performances.The presence of adsorbents partially alleviated the reduction in feed consumption (22.68%, 12.91% and 10.59%), and a similar effect was observed with feed conversion.After the withdrawal of the toxin and adsorbents from the feed (21-42 days), all previously observed disturbances in broilers were reduced, but more remarkably in broilers fed with adsorbents.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia. tjelena@vet.bg.ac.rs.

ABSTRACT
The aim of our study was to determine the efficacy of three different adsorbents, inorganic (modified zeolite), organic (esterified glucomannans) and mixed (inorganic and organic components, with the addition of enzymes), in protecting broilers from the toxic effects of ochratoxin A in feed. Broilers were fed diets containing 2 mg/kg of ochratoxin A (OTA) and supplemented with adsorbents at the recommended concentration of 2 g/kg for 21 days. The presence of OTA led to a notable reduction in body weight, lower weight gain, increased feed conversion and induced histopathological changes in the liver and kidneys. The presence of inorganic, organic and mixed adsorbents in contaminated feed only partially reduced the negative effects of OTA on the broiler performances. Broilers that were fed with adsorbent-supplemented feed reached higher body weight (17.96%, 19.09% and 13.59%), compared to the group that received only OTA. The presence of adsorbents partially alleviated the reduction in feed consumption (22.68%, 12.91% and 10.59%), and a similar effect was observed with feed conversion. The applied adsorbents have also reduced the intensity of histopathological changes caused by OTA; however, they were not able to prevent their onset. After the withdrawal of the toxin and adsorbents from the feed (21-42 days), all previously observed disturbances in broilers were reduced, but more remarkably in broilers fed with adsorbents.

Show MeSH
Related in: MedlinePlus