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Effect of pioglitazone therapy on high sensitive C-reactive protein and lipid profile in diabetic patients with renal transplantation; a randomize clinical trial.

Arashnia R, Roohi-Gilani K, Karimi-Sari H, Nikjoo N, Bahramifar A - J Nephropathol (2015)

Bottom Line: The mean total serum cholesterol was significantly decreased 34 mg/dL in group A and 18.07 mg/dL in group B (P = 0.027).The mean serum HDL-C was significantly increased 13.31 mg/dL in group A and 5.89 mg/dl in group B (P < 0.001).Long term effect of this drug could be evaluated in future studies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid-Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Inflammation has a major role in disease lead to renal failure and diabetes mellitus, controlling inflammation in diabetic kidney receivers could decrease morbidity and mortality.

Objectives: This study designed for evaluating the efficacy of pioglitazone on C-reactive protein and lipid profile in diabetic kidney transplant receivers.

Patients and methods: In this double blinded clinical trial, 58 diabetic renal transplant receivers, in first month after transplantation, randomized into two groups; receiving insulin and pioglitazone (15 mg tablet daily, group A); and insulin and placebo (group B). Blood pressure, weight, body mass index (BMI) and laboratory data compared in before and after 4-month treatment in two groups by SPSS.

Results: Fifty-eight patients with mean age of 44.15 ± 2 years included. There were no significant difference between groups in demographic data and other baseline measured variables (P > 0.05) .The mean weigh and BMI were slightly increased in group A and decreased in group B. The mean hs-CRP was decreased 4.82 mg/dL in group A and 1.93 mg/dL in group B (P = 0.007). The mean total serum cholesterol was significantly decreased 34 mg/dL in group A and 18.07 mg/dL in group B (P = 0.027). The mean serum HDL-C was significantly increased 13.31 mg/dL in group A and 5.89 mg/dl in group B (P < 0.001).

Conclusions: Pioglitazone seems to be a safe drug for reducing serum lipids and CRP in kidney transplant receivers with diabetes mellitus in short term. Long term effect of this drug could be evaluated in future studies.

No MeSH data available.


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Mentions: In this double blind randomized clinical trial, patients who had undergone kidney transplantation with diabetes, entered to the study. Fasting blood glucose (FBS) more than 126 mg/dl, from America diabetes association diagnostic criteria, was used to diagnose diabetes. The study protocol was designed in compliance with the principles of the Helsinki Convention. Cigarette smokers or patients with heart failure FC II, III, hepatitis B and C, GFR less than 30 cc/min, pregnancy, acute rejection with progressive renal impairment and creatinine more than 1 mg/dl did not enter to the study. Patients gave written consent before entering the study. Patients divided randomly into two groups by closed label method. First group received insulin therapy with daily one 15 mg pioglitazone tablet (A) for four months and second group received insulin therapy with placebo tablet (B). Placebo tablets were produced identical in shape and size with pioglitazone by its manufacturer and drug prescriber, those who visit the patients and filled the checklists in all stages as well as the person who performed the analysis were unaware of drug compounds of both groups. At the beginning of the study, all patients were examined and interviewed, information about various diseases and history of present illness and consumed drugs were assessed through biography and present documents. On height, weight and waist circumference examinations, heart, lung and lower extremity examinations carried out for presence of congestive heart failure and other mentioned diseases in the exclusion criteria (Figure 1).


Effect of pioglitazone therapy on high sensitive C-reactive protein and lipid profile in diabetic patients with renal transplantation; a randomize clinical trial.

Arashnia R, Roohi-Gilani K, Karimi-Sari H, Nikjoo N, Bahramifar A - J Nephropathol (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4417670&req=5

Mentions: In this double blind randomized clinical trial, patients who had undergone kidney transplantation with diabetes, entered to the study. Fasting blood glucose (FBS) more than 126 mg/dl, from America diabetes association diagnostic criteria, was used to diagnose diabetes. The study protocol was designed in compliance with the principles of the Helsinki Convention. Cigarette smokers or patients with heart failure FC II, III, hepatitis B and C, GFR less than 30 cc/min, pregnancy, acute rejection with progressive renal impairment and creatinine more than 1 mg/dl did not enter to the study. Patients gave written consent before entering the study. Patients divided randomly into two groups by closed label method. First group received insulin therapy with daily one 15 mg pioglitazone tablet (A) for four months and second group received insulin therapy with placebo tablet (B). Placebo tablets were produced identical in shape and size with pioglitazone by its manufacturer and drug prescriber, those who visit the patients and filled the checklists in all stages as well as the person who performed the analysis were unaware of drug compounds of both groups. At the beginning of the study, all patients were examined and interviewed, information about various diseases and history of present illness and consumed drugs were assessed through biography and present documents. On height, weight and waist circumference examinations, heart, lung and lower extremity examinations carried out for presence of congestive heart failure and other mentioned diseases in the exclusion criteria (Figure 1).

Bottom Line: The mean total serum cholesterol was significantly decreased 34 mg/dL in group A and 18.07 mg/dL in group B (P = 0.027).The mean serum HDL-C was significantly increased 13.31 mg/dL in group A and 5.89 mg/dl in group B (P < 0.001).Long term effect of this drug could be evaluated in future studies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid-Beheshti University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: Inflammation has a major role in disease lead to renal failure and diabetes mellitus, controlling inflammation in diabetic kidney receivers could decrease morbidity and mortality.

Objectives: This study designed for evaluating the efficacy of pioglitazone on C-reactive protein and lipid profile in diabetic kidney transplant receivers.

Patients and methods: In this double blinded clinical trial, 58 diabetic renal transplant receivers, in first month after transplantation, randomized into two groups; receiving insulin and pioglitazone (15 mg tablet daily, group A); and insulin and placebo (group B). Blood pressure, weight, body mass index (BMI) and laboratory data compared in before and after 4-month treatment in two groups by SPSS.

Results: Fifty-eight patients with mean age of 44.15 ± 2 years included. There were no significant difference between groups in demographic data and other baseline measured variables (P > 0.05) .The mean weigh and BMI were slightly increased in group A and decreased in group B. The mean hs-CRP was decreased 4.82 mg/dL in group A and 1.93 mg/dL in group B (P = 0.007). The mean total serum cholesterol was significantly decreased 34 mg/dL in group A and 18.07 mg/dL in group B (P = 0.027). The mean serum HDL-C was significantly increased 13.31 mg/dL in group A and 5.89 mg/dl in group B (P < 0.001).

Conclusions: Pioglitazone seems to be a safe drug for reducing serum lipids and CRP in kidney transplant receivers with diabetes mellitus in short term. Long term effect of this drug could be evaluated in future studies.

No MeSH data available.


Related in: MedlinePlus