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Thickness mapping of eleven retinal layers segmented using the diffusion maps method in normal eyes.

Kafieh R, Rabbani H, Hajizadeh F, Abramoff MD, Sonka M - J Ophthalmol (2015)

Bottom Line: We applied our previously reported 3D intraretinal fast layer segmentation which does not require edge-based image information but rather relies on regional image texture.Temporal and inferior quadrants of the total retinal thickness and most of other quadrants of layer 1 were significantly greater in the men than in the women.Surrounding eight sectors of total retinal thickness and a limited number of sectors in layers 1 and 4 significantly correlated with age.

View Article: PubMed Central - PubMed

Affiliation: Biomedical Engineering Department, Medical Image & Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Faculty of Engineering and Natural Sciences, Sabanci University, 34956 Istanbul, Turkey.

ABSTRACT
This study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Mean regional retinal thickness of 11 retinal layers was obtained by automatic three-dimensional diffusion map based method in 112 normal eyes of 76 Iranian subjects. We applied our previously reported 3D intraretinal fast layer segmentation which does not require edge-based image information but rather relies on regional image texture. The thickness maps are compared among 9 macular sectors within 3 concentric circles as defined by ETDRS. The thickness map of central foveal area in layers 1, 3, and 4 displayed the minimum thickness. Maximum thickness was observed in nasal to the fovea of layer 1 and in a circular pattern in the parafoveal retinal area of layers 2, 3, and 4 and in central foveal area of layer 6. Temporal and inferior quadrants of the total retinal thickness and most of other quadrants of layer 1 were significantly greater in the men than in the women. Surrounding eight sectors of total retinal thickness and a limited number of sectors in layers 1 and 4 significantly correlated with age.

No MeSH data available.


Examples of thickness maps of 11 retinal layers in a right eye of one subject in the study. The 11 retinal layers were the NFL (layer 1), GCL (layer 2), IPL (layer 3), INL (layer 4), OPL (layer 5), ONL + OLM + HFL (layer 6), ISL (layer 7), CL (layer 8), OSL (layer 9), VM (layer 10), and RPE/BM (layer 11).
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Related In: Results  -  Collection


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fig4: Examples of thickness maps of 11 retinal layers in a right eye of one subject in the study. The 11 retinal layers were the NFL (layer 1), GCL (layer 2), IPL (layer 3), INL (layer 4), OPL (layer 5), ONL + OLM + HFL (layer 6), ISL (layer 7), CL (layer 8), OSL (layer 9), VM (layer 10), and RPE/BM (layer 11).

Mentions: layer 11 which is equivalent to retinal pigment epithelium (RPE) which is a single layer of pigmented hexagonal cells/Bruch membrane (BM), the innermost layer of the choroid, also called the vitreous lamina.


Thickness mapping of eleven retinal layers segmented using the diffusion maps method in normal eyes.

Kafieh R, Rabbani H, Hajizadeh F, Abramoff MD, Sonka M - J Ophthalmol (2015)

Examples of thickness maps of 11 retinal layers in a right eye of one subject in the study. The 11 retinal layers were the NFL (layer 1), GCL (layer 2), IPL (layer 3), INL (layer 4), OPL (layer 5), ONL + OLM + HFL (layer 6), ISL (layer 7), CL (layer 8), OSL (layer 9), VM (layer 10), and RPE/BM (layer 11).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4417595&req=5

fig4: Examples of thickness maps of 11 retinal layers in a right eye of one subject in the study. The 11 retinal layers were the NFL (layer 1), GCL (layer 2), IPL (layer 3), INL (layer 4), OPL (layer 5), ONL + OLM + HFL (layer 6), ISL (layer 7), CL (layer 8), OSL (layer 9), VM (layer 10), and RPE/BM (layer 11).
Mentions: layer 11 which is equivalent to retinal pigment epithelium (RPE) which is a single layer of pigmented hexagonal cells/Bruch membrane (BM), the innermost layer of the choroid, also called the vitreous lamina.

Bottom Line: We applied our previously reported 3D intraretinal fast layer segmentation which does not require edge-based image information but rather relies on regional image texture.Temporal and inferior quadrants of the total retinal thickness and most of other quadrants of layer 1 were significantly greater in the men than in the women.Surrounding eight sectors of total retinal thickness and a limited number of sectors in layers 1 and 4 significantly correlated with age.

View Article: PubMed Central - PubMed

Affiliation: Biomedical Engineering Department, Medical Image & Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan 81745, Iran ; Faculty of Engineering and Natural Sciences, Sabanci University, 34956 Istanbul, Turkey.

ABSTRACT
This study was conducted to determine the thickness map of eleven retinal layers in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate their association with sex and age. Mean regional retinal thickness of 11 retinal layers was obtained by automatic three-dimensional diffusion map based method in 112 normal eyes of 76 Iranian subjects. We applied our previously reported 3D intraretinal fast layer segmentation which does not require edge-based image information but rather relies on regional image texture. The thickness maps are compared among 9 macular sectors within 3 concentric circles as defined by ETDRS. The thickness map of central foveal area in layers 1, 3, and 4 displayed the minimum thickness. Maximum thickness was observed in nasal to the fovea of layer 1 and in a circular pattern in the parafoveal retinal area of layers 2, 3, and 4 and in central foveal area of layer 6. Temporal and inferior quadrants of the total retinal thickness and most of other quadrants of layer 1 were significantly greater in the men than in the women. Surrounding eight sectors of total retinal thickness and a limited number of sectors in layers 1 and 4 significantly correlated with age.

No MeSH data available.